Jitender Madan – författare

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials.

This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research.

Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials.This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research.- Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments- Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo- Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications. Explains the fundamentals, concepts, theory and application of multifunctional nanocarriers, with advanced content and applications for a range of biomedical applications Covers production and manufacturing processes for multifunctional nanocarriers for biomedical applications Assesses major challenges in applying multifunctional nanocarriers on an industrial scale

Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications.- Explains the fundamentals, concepts, theory and application of multifunctional nanocarriers, with advanced content and applications for a range of biomedical applications- Covers production and manufacturing processes for multifunctional nanocarriers for biomedical applications- Assesses major challenges in applying multifunctional nanocarriers on an industrial scale

Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of 'Linker Chemistry' in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding.

The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.

Covers mechanism, protocol and therapeutic significance of Polymer-Drug Conjugates Outlines updated methods and techniques to enumerate conjugation with related case studies Includes comprehensive compilation of marketed and clinical trial drugs conjugated with polymers or linkers

Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ''Linker Chemistry'' in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding.The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.- Covers mechanism, protocol and therapeutic significance of Polymer-Drug Conjugates- Outlines updated methods and techniques to enumerate conjugation with related case studies- Includes comprehensive compilation of marketed and clinical trial drugs conjugated with polymers or linkers

Topical Dermal Drug Delivery: Concepts and Advances compiles, in a single volume, the most recent advances in topical and dermal formulations for the treatment of skin disorders.The book covers three major concepts. The skin anatomy and physiology part includes chapters focused on relevant information for drug delivery. The second part of the book deals with several recent topical dermal drug delivery systems, including computational methods, permeation enhancers, bio precursors, hydrogels, emugels, exosomes and several nanotechnology enabled systems. The third and final part covers scaling up, toxicity, clinical trials, and regulatory considerations.This is a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the skin. Medical & Health Sciences researchers would also benefit from understanding the delivery systems covered in this book.

Includes coverage of skin structure, physiology, pharmacology, and skin disordersCovers updated methods and techniques for the customization of novel topical dermal drug delivery systemsProvides a comprehensive compilation of marketed and clinical trials of novel topical dermal drug delivery systems

How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms: From Bench to the Clinics provides a comprehensive roadmap for transitioning complex injectable formulations from the laboratory to clinical applications. Offering an exploration of various complex injectables, including liposomal dosage forms, nanoparticles, and microspheres, this book delves into dosage form design, excipient selection, stability studies, and optimization techniques. The book examines manufacturing technologies such as aseptic processing, sterile filtration, and lyophilization, and their applications in producing complex injectables. Discussions on quality control measures, analytical techniques, and quality assurance practices are provided to ensure consistent quality and purity throughout the manufacturing process.Readers will benefit from the expert knowledge and practical insights shared by industry professionals and leading researchers, including successful examples of marketed complex injectables. Highlighting best practices and regulatory requirements, this book offers a comprehensive overview of the guidelines for the development, manufacturing, and commercialization of complex injectables. Ideal for pharmaceutical scientists, formulation developers, and regulatory professionals, this book is a valuable resource for anyone involved in the scale-up and commercialization of complex injectable dosage forms.Provides comprehensive guidance on scaling-up complex injectables from lab to clinical applicationsOffers in-depth insights into dosage form design, excipient selection, and stability studiesExplores advanced manufacturing technologies and quality control measures for consistent product qualityHighlights regulatory requirements and best practices for compliance with GMP and regulatory submissionsIncludes successful examples and practical insights from industry experts and leading researchers

How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms: From Bench to the Clinics provides a comprehensive roadmap for transitioning complex injectable formulations from the laboratory to clinical applications. Offering an exploration of various complex injectables, including liposomal dosage forms, nanoparticles, and microspheres, this book delves into dosage form design, excipient selection, stability studies, and optimization techniques. The book examines manufacturing technologies such as aseptic processing, sterile filtration, and lyophilization, and their applications in producing complex injectables. Discussions on quality control measures, analytical techniques, and quality assurance practices are provided to ensure consistent quality and purity throughout the manufacturing process.Readers will benefit from the expert knowledge and practical insights shared by industry professionals and leading researchers, including successful examples of marketed complex injectables. Highlighting best practices and regulatory requirements, this book offers a comprehensive overview of the guidelines for the development, manufacturing, and commercialization of complex injectables. Ideal for pharmaceutical scientists, formulation developers, and regulatory professionals, this book is a valuable resource for anyone involved in the scale-up and commercialization of complex injectable dosage forms. - Provides comprehensive guidance on scaling-up complex injectables from lab to clinical applications- Offers in-depth insights into dosage form design, excipient selection, and stability studies- Explores advanced manufacturing technologies and quality control measures for consistent product quality- Highlights regulatory requirements and best practices for compliance with GMP and regulatory submissions- Includes successful examples and practical insights from industry experts and leading researchers