Ramesh Chandra – författare

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance.

The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.

Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance.The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.- Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies- Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc.- Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Topical Dermal Drug Delivery: Concepts and Advances compiles, in a single volume, the most recent advances in topical and dermal formulations for the treatment of skin disorders.The book covers three major concepts. The skin anatomy and physiology part includes chapters focused on relevant information for drug delivery. The second part of the book deals with several recent topical dermal drug delivery systems, including computational methods, permeation enhancers, bio precursors, hydrogels, emugels, exosomes and several nanotechnology enabled systems. The third and final part covers scaling up, toxicity, clinical trials, and regulatory considerations.This is a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the skin. Medical & Health Sciences researchers would also benefit from understanding the delivery systems covered in this book.

Includes coverage of skin structure, physiology, pharmacology, and skin disordersCovers updated methods and techniques for the customization of novel topical dermal drug delivery systemsProvides a comprehensive compilation of marketed and clinical trials of novel topical dermal drug delivery systems

Advancements in Nanotechnology for Electronics and Healthcare: From Materials to Applications provides a comprehensive overview on the foundational principles, cutting-edge applications, and emerging trends related to applications of nanotechnology in electronics and healthcare. The book begins with a discussion on synthesis, fabrication, and characterization of nanomaterials, emphasizing their electronic, optical, and magnetic properties critical for device performance. Chapters also detail the integration of nanoscale structures in semiconductor manufacturing, flexible and wearable electronics, and high-speed computing architectures, including quantum dots, nanotubes, and nanowires. The application of AI-driven methods for nanomaterial design and process optimization is discussed, highlighting predictive modeling approaches. The following chapters focus on biomedical applications, reviewing topics such as plasmonic sensor development, nanocomposite ferrites for biomedical diagnostics, and nanoelectronics in minimally invasive medical devices. The book also addresses state-of-the-art nanofabrication techniques and discusses technical challenges related to scalability, material stability, and system integration. This book is a valuable resource for researchers and scientists who want to learn more about nanoscale materials and their diverse applications in electronics and biomedicine.Reviews the integration of nanoscale structures in semiconductor manufacturing, flexible electronics, high-speed computing, and biomedical technologiesDiscusses AI-driven nanomaterial design and process optimization, addressing advances and challengesCovers the fundamental science of nanomaterial synthesis, fabrication, and characterization, with a focus on their electronic, optical, and magnetic properties

Understanding the molecular mechanisms of cancer is the key for transforming cancer medicine. A substantial proportion of human genes show alternative splicing and mis-regulation of Pre-mRNA splicing is seen in several cancers.This book further investigates these matters. The first few chapters provide an update on the role of genomics in understanding alternative splicing, and targets in cancer pathogenesis. Advances and prospects in applications of nanotechnology for cancer prevention, detection and treatment are a promising field of research. The subsequent chapters provide insights on how nanotechnology-based therapeutics are moving towards revolutionizing cancer and infectious disease treatment by minimizing toxicity and facilitating targeted delivery of drugs. Technical topics discussed in the book include: • Alternative splicing and cancer• Cancer imaging• Nanomaterials in infectious diseases• Nanomedicine in oxidative stress and cancer• Nanoparticle based drug delivery systems

Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. T

Understanding the molecular mechanisms of cancer is the key for transforming cancer medicine. A substantial proportion of human genes show alternative splicing and mis-regulation of Pre-mRNA splicing is seen in several cancers.This book further investigates these matters. The first few chapters provide an update on the role of genomics in understanding alternative splicing, and targets in cancer pathogenesis. Advances and prospects in applications of nanotechnology for cancer prevention, detection and treatment are a promising field of research. The subsequent chapters provide insights on how nanotechnology-based therapeutics are moving towards revolutionizing cancer and infectious disease treatment by minimizing toxicity and facilitating targeted delivery of drugs. Technical topics discussed in the book include: • Alternative splicing and cancer• Cancer imaging• Nanomaterials in infectious diseases• Nanomedicine in oxidative stress and cancer• Nanoparticle based drug delivery systems

Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. T

This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted.

This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted.

This book explores the applications of nanotechnology in Industry 4.0, including how nanotechnology can be used to enhance various manufacturing processes. It discusses the use of nanotechnology in areas such as materials science, energy storage, electronics, biomedical and biotechnology, advanced computing and signal processing, and communication systems. Overall, it highlights the potential of these technologies to transform the manufacturing and production processes of the future.Key Features:Explores nanotechnology applications within Industry 4.0Built on a multidisciplinary approach, it offers a robust exploration of nanotechnology applications across various domains in science and engineeringIncludes detailed case studies and real-world examples reflecting integration of nanotechnology in Industry 4.0Discusses communication protocols and networksReviews development of targeted drug delivery systems, tissue engineering, medical imaging, and diagnostic toolsThis book is aimed at graduate students and researchers in nanotechnology, materials science, and industrial engineering.

This book explores the applications of nanotechnology in Industry 4.0 including how nanotechnology can be used to enhance various manufacturing processes. It discusses the use of nanotechnology in areas such as materials science, energy storage, electronics, biomedical and biotechnology, advanced computing and signal processing, and communication systems. Overall, it highlights the potential for mentioned technologies to transform the manufacturing and production processes of the future.

Explores nanotechnology applications within Industry 4.0 Built on a multidisciplinary approach, it offers a robust exploration of nanotechnology applications across various domains in science and engineering Includes detailed case studies and real-world examples reflecting integration of nanotechnology in Industry 4.0 Discusses communication protocols and networks Reviews development of targeted drug delivery systems, tissue engineering, medical imaging, and diagnostic tools

This book is aimed at graduate students and researchers in nanotechnology, materials science and industrial engineering.

This book explores the applications of nanotechnology in Industry 4.0 including how nanotechnology can be used to enhance various manufacturing processes. It discusses the use of nanotechnology in areas such as materials science, energy storage, electronics, biomedical and biotechnology, advanced computing and signal processing, and communication systems. Overall, it highlights the potential for mentioned technologies to transform the manufacturing and production processes of the future.

Explores nanotechnology applications within Industry 4.0 Built on a multidisciplinary approach, it offers a robust exploration of nanotechnology applications across various domains in science and engineering Includes detailed case studies and real-world examples reflecting integration of nanotechnology in Industry 4.0 Discusses communication protocols and networks Reviews development of targeted drug delivery systems, tissue engineering, medical imaging, and diagnostic tools

This book is aimed at graduate students and researchers in nanotechnology, materials science and industrial engineering.

As many countries have increased their budgets to allow for newer technologies and a stronger military force, defense spending has become a popular debate topic around the world. As such, it is vital to understand the interplay between the military expenditure and economic growth and development across countries. The Handbook of Research on Military Expenditure on Economic and Political Resources is a critical scholarly publication that explores the interplay between the military expenditure and economic growth and development across countries. Featuring coverage on a wide range of topics such as defense management, economic growth, and dynamic panel model, this publication is geared towards academicians, researchers, and professionals seeking current research on the interplay between the military expenditure and economic growth and development across countries.

Microfinance is a broad variety of services, such as microcredit, for entrepreneurs and small businesses lacking access to banking and other financial services. As many smaller businesses and entrepreneurs may not be able to secure credit services, many microfinance promoters believe that it encourages entrepreneurial activities and inclusive growth. Microfinance and Its Impact on Entrepreneurial Development, Sustainability, and Inclusive Growth is an essential resource that empirically explores the role of microfinance in entrepreneurship development and the operational sustainability of microfinance institutions. It also highlights the impact of microfinance on entrepreneurship development in different countries and regions. Featuring coverage on a broad range of topics such as risk management, women entrepreneurship, and strategic management, this book provides essential research for entrepreneurs, business managers, policy makers, researchers in the field of finance, and business professionals seeking relevant research on microfinance systems.

Microfinance is a broad variety of services, such as microcredit, for entrepreneurs and small businesses lacking access to banking and other financial services. As many smaller businesses and entrepreneurs may not be able to secure credit services, many microfinance promoters believe that it encourages entrepreneurial activities and inclusive growth. Microfinance and Its Impact on Entrepreneurial Development, Sustainability, and Inclusive Growth is an essential resource that empirically explores the role of microfinance in entrepreneurship development and the operational sustainability of microfinance institutions. It also highlights the impact of microfinance on entrepreneurship development in different countries and regions. Featuring coverage on a broad range of topics such as risk management, women entrepreneurship, and strategic management, this book provides essential research for entrepreneurs, business managers, policy makers, researchers in the field of finance, and business professionals seeking relevant research on microfinance systems.

One of the major tools of attaining proper development all around the world is complete financial inclusion, such that all classes of people can secure their lifestyles through access to financial services from formal sectors. Expanding access to resources and increasing self-employment opportunities help reduce poverty and improve social development. The Handbook of Research on Microfinancial Impacts on Women Empowerment, Poverty, and Inequality is an essential reference source that discusses the role of financial inclusion in gender equality, as well as economic independence and self-employment. Featuring research on topics such as inequality, collaborative economy, and social responsibility, this publication is ideally designed for policy makers, economic researchers, and academicians seeking coverage on social mobilization, capital formation, capacity building, and pro-poor economy designs.

Industrial houses have, in recent years, begun to favor green products and financial institutions are funneling investible funds to environmentally friendly industries as a priority. Implementation of green policy to support these changes requires economic as well as political support from various influential countries. Success of green policies will inevitably benefit biodiversity and global environmental health. The Handbook of Research on Economic and Political Implications of Green Trading and Energy Use is a scholarly research publication that presents global perspectives on the impact of green financing and accounting on the health of the environment while highlighting issues related to carbon trading, carbon credit, energy use, and energy efficiency and their impact on economic outputs. This reference features a range of topics including environmental policies and sustainable development and is essential for academicians, environmental scientists, policymakers, political scientists, students, and researchers.

Targeted at biology undergraduates, this book covers themes such as cell structure, function, molecular biology, and the fundamental principles of cellular biology. It provides a foundational understanding of cellular biology, which is essential for students pursuing careers in the life sciences. Practitioners in biology and related fields deepen their knowledge of cellular processes, making it a valuable resource for professionals engaged in biological research and applications. Policymakers can draw from this knowledge to inform policies related to scientific research and education, and the general public gains insights into the fundamental building blocks of life and the role of cells in living organisms.

The objective of the book Biodiversity Basics: Celebrating Life's Variety is to raise awareness and appreciation for the richness and importance of Earth's biodiversity. Through its pages, readers are taken on a journey to explore the incredible variety of species, ecosystems, and interactions that make up our planet's web of life. The book aims to educate and inspire individuals to become advocates for biodiversity conservation and sustainable living. It delves into the significance of biodiversity in providing essential ecosystem services, fostering resilience, and contributing to human well-being. Ultimately, Biodiversity Basics seeks to ignite a sense of wonder and responsibility towards protecting and preserving our planet's precious biodiversity for future generations.

This book provides a comprehensive overview of the biochemical processes essential to human life, exploring the structure and function of biomolecules. It covers metabolic pathways, enzyme kinetics, and molecular genetics, emphasizing the biochemical basis of health and disease. The text includes laboratory techniques, clinical correlations, and applications to medical practice. Emphasis is placed on understanding the molecular mechanisms underlying physiological functions and their alterations in pathological conditions.

This book aims to provide a detailed exploration of the structure and function of cells and their molecular components. It covers the fundamental concepts of cell biology, including cell structure, signaling, and division. The book also addresses molecular biology techniques and their applications in research and medicine. It is intended for students, researchers, and educators in the life sciences, offering comprehensive insights into cellular and molecular processes. By enhancing understanding of cell and molecular biology, the book seeks to advance scientific knowledge and its applications in health and disease.

At the heart of modern medicine lies the molecular language that dictates cellular function, metabolism, and heredity. This textbook integrates core biochemical pathways, gene expression regulation, and genetic variation with clinical implications across specialties. It explains enzymology, metabolic networks, nucleic-acid structure and function, and principles of genomics and proteomics in clear, clinically relevant terms. Laboratory techniques — PCR, sequencing, Western blot, and CRISPR basics — are described alongside examples of diagnostic and therapeutic applications. Ethical, counseling, and translational aspects of genetics (carrier screening, pharmacogenomics) are addressed to bridge bench and bedside. Ideal for medical students, laboratory scientists, and clinicians seeking a compact molecular foundation.

Medical biochemistry explains how molecules and biochemical pathways sustain life and how their perturbations produce disease. This first handbook focuses on core metabolic pathways, enzyme kinetics, intermediary metabolism, and the molecular mechanisms underlying inherited and acquired metabolic disorders. It presents laboratory methods used to measure metabolites and enzyme activities and interprets common biochemical test results in clinical contexts. Chapters discuss metabolic regulation, hormonal integration, and biochemical bases of nutrition and energy homeostasis. Clear diagrams and clinical correlation boxes connect molecular detail to diagnostic clues and treatment rationale. Perfect for medical students, clinical chemists, and trainees seeking a compact biochemical primer.

Volume 2 translates foundational biochemistry into organ-system applications and diagnostic problem-solving used in everyday clinical practice. It organizes systemic biochemical pathways—hepatic metabolism, renal handling of solutes, endocrine metabolic effects, and cardiac energetics—alongside disease-associated biochemical derangements. Practical chapters cover interpretation of metabolic panels, inborn errors, toxicology screens, and biomarkers used in cardiometabolic, hepatic, and renal disease management. Case examples illustrate how biochemical reasoning guides therapy, monitoring, and prognostication. The book also highlights advances in clinical proteomics, metabolomics, and personalized medicine that affect biochemical diagnostics. An essential clinical companion for physicians, laboratorians, and students applying biochemistry at the bedside.

Molecular immunology techniques unpack the molecular machinery of immune responses using modern laboratory methods. This book begins with an accessible primer on immune cell types and signaling pathways, then transitions into hands-on protocols: PCR-based assays, flow cytometry panels, ELISAs, single-cell sequencing, and CRISPR editing for immune targets. Each protocol includes reagent lists, stepwise instructions, common pitfalls and troubleshooting tips, plus guidance on experimental design and controls to ensure reproducible results. Data analysis chapters cover gating strategies, normalization, and statistical interpretation for immunology datasets. Safety, biosafety level considerations, and ethical use of samples are emphasized throughout. It's an essential lab companion for immunologists, molecular biologists, and advanced students.

Allyn Young (1876-1929) was a deep thinker and achieved fame during his lifetime. His fame owes more to his style and influence as a teacher than his published work. His greatest fame as an author rests on a single economic paper on increasing returns and economic progress but he contributed much more as a mentor to his graduate students such as Frank Knight, Edward Chamberlin, and Lauchlin Currie at Harvard and to the undergraduate Nicholas Kaldor at the London School of Economics. He shot into international fame for his role as a member of the American delegation led by President Woodrow Wilson to negotiate peace at Paris after WWI. However, recent interest in Young is more due to his thought than to his contribution to the economics profession or public service. At the time of his death, he was working on two treatises, one on Money and the other on Economics. The one on Money was at a fairly advanced stage but no trace of either was found in his family’s hasty departure from London after his untimely death.There is a general dearth of published material about Young, his thought and his life. His economic thought, apart from his views on growth theory and monetary economics, is relatively unknown. This volume offers a thematic approach to his contributions and biography.