Nidhi Gupta – författare
2 112 kr
Skickas inom 10-15 vardagar
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance.
The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.
Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field310 kr
Skickas inom 10-15 vardagar
1 666 kr
Skickas inom 10-15 vardagar
786 kr
Skickas inom 10-15 vardagar
2 131 kr
Skickas inom 10-15 vardagar
1 252 kr
Kommande
431 kr
Skickas inom 3-6 vardagar
278 kr
Skickas inom 5-8 vardagar
232 kr
Skickas inom 5-8 vardagar
339 kr
Skickas inom 5-8 vardagar
232 kr
Skickas inom 5-8 vardagar
2 131 kr
Skickas inom 10-15 vardagar
250 kr
Skickas inom 5-8 vardagar
223 kr
Skickas inom 5-8 vardagar
1 053 kr
Skickas inom 5-8 vardagar
1 062 kr
Skickas inom 5-8 vardagar
927 kr
Skickas inom 5-8 vardagar
1 053 kr
Skickas inom 5-8 vardagar
927 kr
Skickas inom 5-8 vardagar
1 325 kr
Skickas inom 10-15 vardagar
1 435 kr
Skickas inom 10-15 vardagar
1 325 kr
Skickas inom 10-15 vardagar
1 325 kr
Skickas inom 10-15 vardagar
566 kr
Skickas inom 5-8 vardagar
518 kr
Skickas inom 5-8 vardagar
479 kr
Skickas inom 5-8 vardagar
566 kr
Skickas inom 5-8 vardagar
1 325 kr
Skickas inom 10-15 vardagar
941 kr
Skickas inom 10-15 vardagar
1 654 kr
Skickas inom 10-15 vardagar