Nidhi Gupta – författare

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance.

The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.

Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Food which nanotechnology has impacted or to which nanotechnology is applied is referred to as nanofood.  From treatment of the soil in which a crop plant is grown to the caring of a food, nanotechnology is a growing factor in the food supply. At this point, however, there is no definitive, effective global method for regulating the use of nanotechnology as it relates to the food suply.Legislation on nanotechnologies is still evolving, as is understanding what data is needed for effective, efficient and appropriate risk assessment associated with nanotechnology impacted foods. Due to the emerging nature of nanotechnology and its role in the food supply, case-by-case studies are the current norm, but the need for wide-scale testing and broad-based regulatory standards is urgent.This project is based on an EFFoST study designed to provide a comparative study of nanofood regulations in order to guide regulation development in this rapidly expanding market.

Cancer Therapy: Potential Applications of Nanotechnology provides readers with a compendium of all the latest research work in cancer therapeutics, including an emphasis on work in nanotechnology and polymeric nanoparticles. While there have been a large number of ongoing research projects and publications on the treatment of cancer, there is a limited number of books related to nanotechnology, especially those with an emphasis on polymeric nanoparticles in cancer therapy. This title enlightens researchers and students and provides exhaustive knowledge on the topics covered.Provides a complete overview of the application of different polymeric nanoparticles in cancer therapeutics: from characterization of nanoparticles to in vitro and in vivo studies.Contains a detailed description of the delivery of therapeutic molecules with different polymers realized with nanomedicine in cancer therapeutics.Discusses newly developed promising polymers in cancer.Describes polymeric nanoparticle and their role in theranostics pertaining to cancer.Reviews clinical relevance of different polymeric formulations in the field of cancer

This book presents state-of-the-art optimization algorithms followed by Internet of Things (IoT) fundamentals. The applications of machine learning and IoT are explored, with topics including optimization, algorithms and machine learning in image processing and IoT.Applications of Optimization and Machine Learning in Image Processing and IoT is a complete reference source, providing the latest research findings and solutions for optimization and machine learning algorithms. The chapters examine and discuss the fields of machine learning, IoT and image processing.KEY FEATURES:• Includes fundamental concepts towards advanced applications in machine learning and IoT.• Discusses potential and challenges of machine learning for IoT and optimization• Reviews recent advancements in diverse researches on computer vision, networking and optimization field.• Presents latest technologies such as machine learning in image processing and IoTThis book has been written for readers in academia, engineering, IT specialists, researchers, industrial professionals and students, and is a great reference for those just starting out in the field as well as those at an advanced level.

This book presents state-of-the-art optimization algorithms followed by Internet of Things (IoT) fundamentals. The applications of machine learning and IoT are explored, with topics including optimization, algorithms and machine learning in image processing and IoT.Applications of Optimization and Machine Learning in Image Processing and IoT is a complete reference source, providing the latest research findings and solutions for optimization and machine learning algorithms. The chapters examine and discuss the fields of machine learning, IoT and image processing.KEY FEATURES:• Includes fundamental concepts towards advanced applications in machine learning and IoT.• Discusses potential and challenges of machine learning for IoT and optimization• Reviews recent advancements in diverse researches on computer vision, networking and optimization field.• Presents latest technologies such as machine learning in image processing and IoTThis book has been written for readers in academia, engineering, IT specialists, researchers, industrial professionals and students, and is a great reference for those just starting out in the field as well as those at an advanced level.

Generative AI technologies are reshaping the way we create, communicate, and compute, presenting both unprecedented opportunities and profound challenges. As these systems increasingly influence decisions that shape our lives, it becomes clear that performance metrics alone cannot define their success. A deeper understanding of the intersection between technical innovation and human values is essential to navigate this transformative era.The Art and Ethics of Generative AI: Fairness, Transparency, and Human Values provides a balanced exploration of generative AI, combining technical insights with ethical considerations. It explains generative model architectures and learning paradigms in an accessible way, while addressing critical issues such as algorithmic bias, explainability challenges, and emerging regulatory approaches. Practical frameworks for responsible AI development are offered, alongside multidisciplinary perspectives that bridge technical and humanistic viewpoints. Abstract concepts are brought to life through practical illustrations, demonstrating how ethical considerations play out in real-world AI applications.Designed for a wide audience, the book serves AI practitioners seeking actionable guidance for building responsible systems, researchers exploring nuanced ethical dimensions, educators and students looking for comprehensive learning materials, and policymakers needing governance insights. It is an essential resource for anyone engaged in the rapidly evolving AI ecosystem.

This new volume discusses contemporary issues facing entrepreneurs and businesses in high-growtheconomies in the digital age, focusing on the integration of entrepreneurship and sustainability, offering aproactive approach to addressing global challenges, creating value for society, and ensuring the long-termviability of businesses. The authors contend that entrepreneurs who embrace sustainability contribute to amore resilient and responsible economic landscape. With this in mind, the book focuses on sustainabledevelopment in marketing, finance, human resource management, operations, family business, and othercross-functional areas for business excellence. Each chapter delves into distinct dimensions of thistransformative journey, shedding light on the innovation, entrepreneurship, emerging ecosystem, andethical considerations that accompany the widespread insights on sustainable business development.

Critical care in obstetrics is an upcoming specialty in the developing countries. This book is first of its kind as there are very few books written on this subject. The book discusses various aspects of critical care in obstetrics starting from the basic principles, physiology, ethics, monitoring and organization of a critical care unit. The various chapters cover management of life threatening illnesses involving various organ systems of the body of a pregnant woman. Furthermore, the management of a pregnant woman is unique as it involves not only management of the patient but the developing fetus in her womb as well. This book aims to help the obstetricians, postgraduate students and critical care providers with the management protocols in dealing with critically ill pregnant women.

Critical care in obstetrics is an upcoming specialty in the developing countries. This book is first of its kind as there are very few books written on this subject with the South East Asian perspective. The book discusses various aspects of critical care in obstetrics starting from the basic principles, physiology, ethics, monitoring and organization of a critical care unit. The various chapters cover management of life threatening illnesses involving various organ systems of the body of a pregnant woman. Furthermore, the management of a pregnant woman is unique as it involves not only management of the patient but the developing fetus in her womb as well. This book aims to help the obstetricians, postgraduate students and critical care providers with the management protocols in dealing with critically ill pregnant women.

The book discusses various aspects of critical care in obstetrics starting from the basic principles, physiology, ethics, monitoring and organization of a critical care unit. This book aims to help the obstetricians, postgraduate students and critical care providers with the management protocols in dealing with critically ill pregnant women.

The book discusses various aspects of critical care in obstetrics starting from the basic principles, physiology, ethics, monitoring and organization of a critical care unit. This book aims to help the obstetricians, postgraduate students and critical care providers with the management protocols in dealing with critically ill pregnant women.

This book provides basic information on neuroanesthesia, comprehensively discussing the brain and spine anatomy, physiology and relevant pharmacology. It also explores various co-existing medical conditions in neurosurgical patients and their medical management relevant to anesthesia, with each problem presented in a standard format. Written by experts in the field and including illustrations, flowcharts and images, each chapter begins with a brief clinical scenario and include the latest evidence-based information. This book is a valuable guide for all anesthetists, not only dedicated neuroanesthetists.

This book provides basic information on neuroanesthesia, comprehensively discussing the brain and spine anatomy, physiology and relevant pharmacology. Written by experts in the field and including illustrations, flowcharts and images, each chapter begins with a brief clinical scenario and include the latest evidence-based information.

This book discusses normal brain physiology and renal physiology, as well as the interactions between the two. The book addresses the basic aspects of neurophysiology and renal physiology in three broad sections, the first of which covers the basic principles of cerebral physiology and neural regulation of the renal system.

This book discusses normal brain physiology and renal physiology, as well as the interactions between the two. The book addresses the basic aspects of neurophysiology and renal physiology in three broad sections, the first of which covers the basic principles of cerebral physiology and neural regulation of the renal system.