Sachin Kumar Singh – författare

Advanced Drug Delivery Systems for Colonic Disorders presents state-of-the-art methods for targeted drug delivery to the colon. These methods can prolong drug half-lives, improve bioavailability, optimize pharmacokinetics, and reduce medication dosing frequency. Chapters allow readers to not only become familiar with advancements, but also understand concepts by providing illustrations, figures, and informative tables. Contents cover an overview of colonic diseases, the cellular and molecular mechanisms involved, current and traditional therapeutic approaches, biomaterials, oral drug delivery methods, targeted drug delivery, nutraceuticals and herbal medicine approaches, prebiotics, probiotics and symbiotics, nanomedicine approaches, and the status of clinical trials.This book is the perfect resources for researchers in pharma, biomaterials, and nutrition to help familiarize them with new and upcoming therapeutic methods. Research physicians in GI can also benefit from reading this book for its clinical applications.

Covers recent perspectives and challenges towards the treatment of colonic disordersProvides insights into how advanced drug delivery systems can be effectively used for the management of various types of colonic disordersDiscusses drug delivery strategies to manage inflammatory bowel disease (chronic inflammation in the digestive tract), ulcerative colitis (inflammation and ulcers in colon), Crohn's disease, Colonic polyps, Shigellosis, Colon Bleeding or Hemorrhage, Diverticulosis and colon cancer

Extra-intestinal Applications of Fecal Microbiota Transplantation, Volume Two: Future Directions and Applications in Neuropsychiatric, Infectious, and Cardiovascular Diseases provides real world applications of Fecal Microbiota Transplantation (FMT) in various neuropsychiatric, infectious, and cardiovascular pathologies. The content provides a comprehensive view of FMT beyond intestinal pathologies, including content on extra-intestinal applications of FMT and lesser-known concepts of gut brain axis and the heart gut axis. Content coverage also includes a comparison of regulatory guidelines for FMT in various countries and various routes of administration of FMT with advantages and limitations.This is the perfect reference for researchers involved in work on bacteriotherapeutics as it provides a comprehensive view of the extra-intestinal applications of FMT while discussing the lesser known concepts of the gut axis.

Extra-intestinal Applications of Fecal Microbiota Transplantation: Volume One: Foundations and Applications in Metabolic, Respiratory, Hormonal, and Dermatological Diseases provides real world applications of Fecal Microbiota Transplantation (FMT) in various metabolic, respiratory, hormonal, and dermatological disease pathologies. The content provides a comprehensive view of FMT beyond intestinal pathologies, including content on extra-intestinal applications of FMT and lesser-known concepts of gut brain axis, gut lung axis, gut skin axis and gut vagina bladder axis. Content coverage also includes a comparison of regulatory guidelines for FMT in various countries and various routes of administration of FMT with advantages and limitations.This is the perfect reference for researchers involved in work on bacteriotherapeutics as it provides a comprehensive view of the extra-intestinal applications of FMT while discussing the lesser known concepts of the gut axis.

Lung Cancer and Environmental Toxicants aims to explore the intricate relationship between lung cancer and environmental toxicants, shedding light on a hidden link that demands urgent attention. This groundbreaking book addresses a critical gap in the current literature by introducing a pioneering exploration of the interplay between lung cancer and environmental toxicants. Previous articles have not coalesced into a comprehensive examination of the complex connection between lung cancer development and the diverse array of environmental toxicants. This book delves into the latest scientific research and clinical findings to offer a clear way forward for healthcare workers to assess and treat lung cancer patients who may have been exposed to these substances. "Lung Cancer and Environmental Toxicants" provides a precise view of the impact of environmental toxicants on lung cancer, covering various aspects including epidemiology, molecular mechanisms, exposure pathways, and preventive measures. This unique and timely work will pave the way for a deeper understanding of the underexplored factors contributing to lung cancer incidence, offering novel insights into the role of various toxic substances in disease causation. This significant title will catalyze new avenues of research and awareness in the fields of oncology, environmental health, and public policy.Unlocks the intricate nexus between lung cancer and environmental toxicants, offering an unprecedented exploration of complex mechanisms and interactions for advancing research in oncology and environmental healthTakes a global perspective on lung cancer and environmental toxicants, considering the prevalence of the disease and its causes in different regions of the world, as well as addressing the challenges faced by developing nationsPresents rigorous, evidence-based research on the effects of toxicants on the human lung, ensuring the book’s indispensability

Innovative Targeting Strategies in Breast Cancer Therapy is a comprehensive reference addressing the challenge of non-specific drug distribution in the body, along with severe toxicity and adverse effects, by offering insights into targeted breast cancer treatment. It further educates researchers on formulating and developing novel carriers with target-specific attributes (such as targeted liposomes, nanoparticles, micelles, and dendrimers), contributing to a more refined approach to breast cancer. This book's content is presented in 12 chapters. The first chapters introduces the reader to the different breast cancer therapies followed by indepth information on targeting . Recognizing the need for targeted drug delivery in breast cancer treatment, this book presents an encompassing compilation of advanced research and formulation strategies. By focusing on effectively targeting cancer cells, the book mitigates dose-related toxicity associated with cytotoxic drugs, providing a comprehensive resource for improved treatment approaches. Research in oncology, pharmacology, medical researchers, biomedical engineers and clinical professionals will find this an essential reference.Delves into the intricacies of delivering drugs in cancer precisely to designated sites through molecular recognitionProvides in-depth coverage of existing market formulations, ongoing clinical trials, and intellectual property rights pertaining to targeted breast cancer therapiesOffers researchers up-to-date insights into breast cancer targeting strategies

This book discusses the potential application of self-nanoemulsifying drug delivery systems (SNEDDS) in different inflammatory diseases. It introduces the fundamental principles of SNEDDS, their formulation components, and characterization techniques, providing insights into their mechanisms of drug delivery and formulation optimization. The book also explores the potential of various combination therapies with SNEDDS, highlighting strategies, synergistic effects, and challenges. Furthermore, the chapters in the book highlight the applications of SNEDDS in specific inflammatory diseases, including diabetes, brain diseases, colorectal diseases, cardiovascular diseases, lung diseases, and cancer. Towards the end, the book evaluates the potential toxic effects of SNEDDS components and addresses safety considerations, regulatory aspects, patents, and clinical trials pertaining to SNEDDS. This book is intended for researchers, pharmacologists, pharmaceutical scientists, and clinicians involved in drug delivery and nanomedicine.

This book reviews the evolving field of epigenetics and its implications for drug discovery and precision medicine. It also focuses on the intricate mechanisms governing gene regulation and the impact of epigenetics on health and disease. The book encompasses the complexities of epigenetic mechanisms and their role in diseases such as cancer, autoimmune disorders, inflammatory conditions, and neurodegenerative diseases. Additionally, it examines the role of miRNA as an epigenetic drug in treating cancer and in-silico approaches to epigenetic drug discovery. The book uncovers the potential of epigenetic drug discovery, including insights into traditional medicine, marine sources, and OMICS technologies. Moreover, it explores the interplay between gut microbiota, probiotics, and prebiotics in epigenetic therapeutic approaches. With a focus on personalized medicine and recent advancements in drug delivery systems, this book is intended for researchers, clinicians, and pharmaceutical professionals seeking to explore epigenetic drug discovery and development.Key featuresDiscusses the implications of epigenetic mechanisms in different diseases and epigenetic based drug discoveryReviews development of targeted therapies based on epigenetic mechanisms for cancer, autoimmune diseases, neurodegenerative conditions, and inflammatory diseasesEmphasizes the importance of precision medicine and personalized therapies based on epigenetic profilingExplores application of artificial intelligence in designing novel delivery systems for epigenetic drugsPresents role of advance in-silico and drug discovery tools in the development of epigenetic drugs

mso-bidi-font-weight: bold;">This book presents detailed analyses of various minimally invasive drug delivery methods as well as the recent advances in devices such as microneedles, iontophoretic devices, probes, etc.

The book explores the intersection of nanotechnology and allergic airway diseases. Beginning with an introduction to the diseases, the book progresses to uncover the pathophysiology and immunology underlying allergic airway diseases.

This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications.