Prashant Tiwari – författare

As research continues to uncover the complex causes of Alzheimer’s disease, a deeper understanding of its cellular and molecular mechanisms is essential for developing effective therapies. Cellular and Molecular Mechanisms in Alzheimer’s Disease Therapeutics, a two volume set, provides a comprehensive examination of the processes driving disease onset and progression, bringing together leading experts to illuminate key pathways, therapeutic targets, and emerging treatment strategies. Volume 1: Cellular Mechanisms explores the cellular mechanisms underlying Alzheimer’s disease—such as synaptic dysfunction, neuroinflammation, mitochondrial impairment, and protein aggregation—while highlighting their therapeutic implications, including personalized medicine, blood–brain barrier dynamics, and micro RNA-based approaches. Volume 2: Molecular Mechanisms examines AD at the molecular level—covering protein aggregation, cellular dysfunction, and neuroinflammation—while integrating emerging therapies, personalized approaches, and global research efforts to bridge fundamental mechanisms with clinical applications.

As research continues to uncover the complex causes of Alzheimer’s disease, a deeper understanding of its cellular and molecular mechanisms is essential for developing effective therapies. Cellular and Molecular Mechanisms in Alzheimer’s Disease Therapeutics, a two volume set, provides a comprehensive examination of the processes driving disease onset and progression, bringing together leading experts to illuminate key pathways, therapeutic targets, and emerging treatment strategies. Volume 1: Cellular Mechanisms explores the cellular mechanisms underlying Alzheimer’s disease—such as synaptic dysfunction, neuroinflammation, mitochondrial impairment, and protein aggregation—while highlighting their therapeutic implications, including personalized medicine, blood–brain barrier dynamics, and micro RNA-based approaches. Volume 2: Molecular Mechanisms examines AD at the molecular level—covering protein aggregation, cellular dysfunction, and neuroinflammation—while integrating emerging therapies, personalized approaches, and global research efforts to bridge fundamental mechanisms with clinical applications.

This book offers a detailed exploration of G-protein-coupled receptors (GPCRs), key membrane proteins that mediate cellular responses to diverse signals. It covers GPCR activation, regulation, structural advances, technological innovations, and drug discovery, emphasizing their crucial roles in physiology and therapy. By integrating molecular insights with clinical applications, the book bridges basic science and translational research in GPCR biology.GPCRs function as vital cellular communication hubs by activating guanine nucleotide-binding proteins (G proteins) to transduce extracellular signals into intricate intracellular pathways. These signaling cascades regulate processes such as cell growth, gene expression, and intercellular communication, crucial for maintaining cellular homeostasis. Disruptions in GPCR signaling are linked to diverse pathologies, making them prime targets for therapeutic intervention.The book begins with GPCR structure and activation mechanisms, followed by signaling networks and receptor regulation. It then covers breakthroughs in structural biology and cutting-edge research technologies. Drug discovery strategies, including allosterism and biased signaling, are explored next. Systems biology and molecular pathologies provide deeper insights into GPCR functions and diseases. The final chapters focus on cellular toxicity, preclinical to clinical drug development, and future research challenges.This resource is designed for researchers and scientists in molecular pharmacology, cell biology, and drug discovery, as well as graduate and postgraduate students. Pharmaceutical industry professionals, educators, trainees, and healthcare professionals engaged in GPCR-targeted therapies will also find this book an essential guide to the latest advances and clinical applications.

This book offers a detailed exploration of G-protein-coupled receptors (GPCRs), key membrane proteins that mediate cellular responses to diverse signals. It covers GPCR activation, regulation, structural advances, technological innovations, and drug discovery, emphasizing their crucial roles in physiology and therapy. By integrating molecular insights with clinical applications, the book bridges basic science and translational research in GPCR biology.GPCRs function as vital cellular communication hubs by activating guanine nucleotide-binding proteins (G proteins) to transduce extracellular signals into intricate intracellular pathways. These signaling cascades regulate processes such as cell growth, gene expression, and intercellular communication, crucial for maintaining cellular homeostasis. Disruptions in GPCR signaling are linked to diverse pathologies, making them prime targets for therapeutic intervention.The book begins with GPCR structure and activation mechanisms, followed by signaling networks and receptor regulation. It then covers breakthroughs in structural biology and cutting-edge research technologies. Drug discovery strategies, including allosterism and biased signaling, are explored next. Systems biology and molecular pathologies provide deeper insights into GPCR functions and diseases. The final chapters focus on cellular toxicity, preclinical to clinical drug development, and future research challenges.This resource is designed for researchers and scientists in molecular pharmacology, cell biology, and drug discovery, as well as graduate and postgraduate students. Pharmaceutical industry professionals, educators, trainees, and healthcare professionals engaged in GPCR-targeted therapies will also find this book an essential guide to the latest advances and clinical applications.

Brain Tumour Drug Development provides a clear, multidisciplinary update on modern therapies for glioblastoma and other aggressive brain tumours. The book focuses on improving drug precision, crossing the blood-brain barrier, identifying biomarkers, designing effective trials, and accelerating translation from research to real patient care. Key Features Overcomes the blood-brain barrier using advanced delivery methods Improves drug penetration & specificity with nano and polymer-based systems Explores new therapies through immunotherapy, gene therapy, and personalised medicine Builds preclinical models & identifies biomarkers to support clinical success Designs regulatory-aligned clinical trial strategies for faster translation

Brain Tumour Drug Development provides a clear, multidisciplinary update on modern therapies for glioblastoma and other aggressive brain tumours. The book focuses on improving drug precision, crossing the blood-brain barrier, identifying biomarkers, designing effective trials, and accelerating translation from research to real patient care. Key Features Overcomes the blood-brain barrier using advanced delivery methods Improves drug penetration & specificity with nano and polymer-based systems Explores new therapies through immunotherapy, gene therapy, and personalised medicine Builds preclinical models & identifies biomarkers to support clinical success Designs regulatory-aligned clinical trial strategies for faster translation