Microfluidic Platforms for Rapid Antibiotic Susceptibility Testing (AST)

Accelerating Diagnosis and Optimizing Antimicrobial Therapy

AvRaju Khan,Tanmay Vyas

Häftad, Engelska, 2027

Del i serien Developments in Applied Microbiology and Biotechnology

1 821 kr

Kommande

Beskrivning

Microfluidic Platforms for Rapid Antibiotic Susceptibility Testing (AST): Accelerating Diagnosis and Optimizing Antimicrobial Therapy provides a comprehensive and interdisciplinary exploration of microfluidic technologies as transformative tools in the fight against antimicrobial resistance (AMR). By integrating foundational knowledge of AMR and microfluidics with cutting-edge research, it offers readers an in-depth understanding of how microfluidic systems enable rapid, precise, and cost-effective antibiotic susceptibility testing (AST). The book addresses both the scientific principles and practical applications of these technologies, emphasizing their potential to revolutionize diagnostics, personalize treatment, and improve global health outcomes amidst the growing threat of drug-resistant infections. Organized into five key parts, the book begins with an overview of the global challenge of antimicrobial resistance and the fundamental principles of microfluidics in biomedical contexts. It then delves into various microfluidic platforms for AST, including continuous flow and droplet-based systems, as well as single-cell trapping techniques. Subsequent chapters focus on diverse detection methods-optical, electrochemical, and acoustic-for monitoring bacterial growth and antibiotic response. The book further explores specialized approaches such as paper-based point-of-care devices, biosensing strategies, and personalized medicine applications. The final section addresses clinical translation, covering validation, regulatory considerations, device design, automation, emerging technologies, ethical guidelines, and future perspectives on microfluidic AST’s role in combating antimicrobial resistance worldwide.

Explain the global threat of antimicrobial resistance and the fundamental principles of microfluidics to establish a strong foundation for understanding rapid diagnostic technologies
Describe various microfluidic technologies and techniques-including continuous flow systems, droplet-based methods, and single-cell manipulation-for performing antibiotic susceptibility tests with high precision and throughput
Illustrate diverse detection and quantification methods for bacterial growth, such as optical, electrochemical, and acoustic techniques, to enable accurate and rapid antibiotic susceptibility analysis
Present specialized approaches for point-of-care and personalized antibiotic susceptibility testing using paper-based devices, biosensors, and tailored microfluidic platforms
Address clinical translation by detailing validation processes, device design, automation, ethical considerations, and emerging technologies to facilitate implementation and future advancements in microfluidic antibiotic susceptibility testing.

Produktinformation

Utgivningsdatum:2027-02-01
Mått:191 x 235 x undefined mm
Vikt:450 g
Format:Häftad
Språk:Engelska
Serie:Developments in Applied Microbiology and Biotechnology
Antal sidor:400
Förlag:Elsevier Science
ISBN:9780443453298

Utforska kategorier

Biologi inom Naturvetenskap och teknik

Mer om författaren

Raju Khan is a Senior Principal Scientist and Professor, at CSIR-Advanced Materials and Processes Research Institute, Bhopal. He did his PhD in Chemistry in 2005 from Jamia Millia Islamia, Central University, New Delhi, and Postdoctoral researcher at the “Sensor Research Laboratory University of the Western Cape, Cape Town. His current research involved synthesizing novel materials to fabricate electrochemical and fluorescence-based biosensors integrated with microfluidics to detect target disease risk biomarkers for health care monitoring. He has published over 150 papers in SCI journal, which attracted over 5500 citations as per Google Scholar, published 45 book chapters in the reputed book Elsevier and Taylor Francis, editing of 28 books from Elsevier and Taylor Francis, and his research has been highlighted in Nature India. He has supervised 5 PhD and 30 undergraduate/postgraduate theses and has supervised 4 numbers of postdoctoral fellows under the scheme of N-PDF, CSIR-Nehru Fellowship, and DST-Women Scientist Projects. Dr. Tanmay Vyas is currently a Post Doctoral Research Associate at CSIR-Advanced Materials and Processes Research Institute (AMPRI) in Bhopal, India. He earned his PhD in Biosciences and Biomedical Engineering from the Indian Institute of Technology (IIT) Indore, Madhya Pradesh, India. He was an awardee of the prestigious Prime Minister Research Fellowship (PMRF) and DST-INSPIRE fellowship. He is currently working on a research project at CSIR-AMPRI Bhopal on the “Design and development of a microfluidics-based device to determine antimicrobial susceptibility directly in clinical samples. His current research includes the design and development of microfluidics-based devices, 3D bioprinting devices, and electrochemical and optical sensing platforms for environmental and healthcare monitoring. Dr. Vyas has a particular interest in carbon dots, quantum dots-based nanocomposites, and their effective application in the purview of theragnostics, biosensors, and chemical sensors for environmental and healthcare monitoring. Dr. Vyas has published several research articles, review articles, and book chapters during his research tenure. Mohd. Abubakar Sadique is a Ph.D. research scholar under the supervision of Dr. Raju Khan at CSIR-AMPRI, Bhopal. India. He has worked as a Senior Project Fellow at CSIR-CEERI, Pilani, Rajasthan, India, on a mission-mode project titled "Design and Fabrication of a Microfluidic-Based Bio-Sensor for Biochemical Detection." His recent research includes the use of nanotechnology for healthcare applications. Mr. Sadique’s research interests include green synthesis, electrochemical studies of nanomaterials, their characterization, and their healthcare applications. Mr. Sadique has a particular interest in carbon-based nanostructures for their effectiveness in the purview of bio-sensing, diagnostics, therapeutics, and healthcare applications. He has been associated with various research and development projects funded by different agencies, which include the Department of Science and Technology and the Council of Scientific and Industrial Research (CSIR), India. Mr. Sadique has published several review and research articles, three books edited, and numerous book chapters during his brief research tenure.Dr Saikat Das is working as Additional Professor, Department of Radiation Oncology, and Associate Dean (Nursing and Allied Health Sciences) AII India Institute of Medical Sciences Bhopal. He has made significant contribution in the field of Radiation Oncology and Bio-Engineering. His research work is focused on the development of newer treatment paradigms through translational approach. He is principal investigator and co-Principal Investigator in many extramural projects funded by all major funding agencies including DBT, DST, SERB, BIRAC, ICMR. Considering his contributions in the Field of Radiation Oncology, based on academic accomplishments and peer recognition, he was selected as Fellow, Indian College of Radiation Oncology (FICRO) 2023. Dr. Abhijeet Joshi is currently an Associate Professor in the Department of Biosciences and Biomedical Engineering at the Indian Institute of Technology (IIT) Indore, Madhya Pradesh, India. He has a Bachelor of Pharmacy, MS Pharm degree, and earned his PhD degree in Biomedical Engineering. His research interests focus on interdisciplinary areas of biosensors, drug delivery, novel materials for biomedical applications, nano-biotechnology, and theragnostics. He has published over 70 publications in reputed journals, filed about 8 patents with over 1100 citations, and contributed over 8 book chapters from various international publishers including CRC Press, Springer, Elsevier, and RSC. He has secured several awards including the Technology Development Award, SERB Early Career Award, DST INSPIRE Faculty Award, TR35 Young Investigator Award, DBT Innovative Young Biotechnologist Award, and the Gandhian Young Technology Award. In his research group, he supervises over 10 PhD students and graduated over 15 post-graduate students.

Innehållsförteckning

Part 1: Fundamentals and Foundations1. Understanding the Global Threat of Antimicrobial Resistance2. Principles of Microfluidics for Biomedical ApplicationsPart 2: Microfluidic Technologies for Antibiotic Susceptibility Test (AST)3. Continuous Flow Microfluidic Systems for Antibiotic Susceptibility Test (AST)4. Droplet-based microfluidics for Antibiotic Susceptibility Test (AST)5. Cell Trapping and Manipulation TechniquesPart 3: Detection and Quantification of Bacterial Growth 6. Optical Methods for Bacterial Growth Monitoring7. Electrochemical Methods for Antibiotic Susceptibility Test (AST)8. Acoustic Methods for Bacterial DetectionPart 4: Specialized Approaches for AST9. Paper-Based Microfluidic Devices for Point-of-Care AST10. Sensing Strategies for Rapid Antibiotic Susceptibility Test (AST)11. Microfluidics for Personalized Medicine in Antibiotic Susceptibility Test (AST)Part 5: Clinical Translation and Future Directions12. Clinical Validation and Regulatory Considerations for Microfluidic Antibiotic Susceptibility Test (AST)13. Point-of-Care AST Devices: Design and Implementation14. Automation and Integration of Microfluidic AST Systems15. Challenges and Limitations of Microfluidic AST16. Emerging Technologies in Microfluidic Antibiotic Susceptibility Test (AST)17. Self-Powered Microfluidic for Antibiotic Susceptibility Test (AST)18. Ethical and Regulatory Guidelines for design of Microfluidics system for Antibiotic Susceptibility Test (AST)19. The Future of Microfluidic AST in Combating Antimicrobial Resistance