In this issue of Surgical Oncology Clinics, guest editor Dr. Gregory D. Kennedy brings his considerable expertise to the topic of Updates in Colorectal Cancer. In recent years, this field has experienced a transformative shift driven by a deeper understanding of tumor biology, molecular genetics, and technological innovations. These developments have facilitated more precise diagnostic tools, personalized treatment approaches, and targeted therapies, fundamentally altering the landscape of CRC management. In this issue, top experts address key topics in colorectal cancer, including our current understanding of biology and resistance to chemoradiation to surgical treatment, algorithms for management of disease, and new uses for artificial intelligence for intraoperative decision making and predicting risk for disease.