In this issue of Neurosurgery Clinics, guest editors Drs. Nicholas Theodore and Michael Y. Wang bring their considerable expertise to the topic of Enhanced Navigation, Image Guidance, and Robotics in Spine Surgery. Recent advances in biomedical engineering have made possible the widespread application of technologies for performing surgeries with navigation, augmented reality, and robotics. In this issue, top experts discuss how these enabling technologies offer the opportunity to perform more complex surgeries in a more precise, optimal, and standardized manner.