Mechanobiology and Mechanomedicine

Mechanobiology and Mechanomedicine: From Fundamentals to Applications offers an in-depth investigation of the role mechanical stimuli plays in biological systems, from cellular behavior to disease development. Organized into three parts, the book initially covers the fundamentals of mechanobiology, exploring cellular and molecular mechanobiology including mechanical force types, mechanosensors and transducers, mechanosensitive signaling pathways and nuclear mechanotransduction. In addition, the application of finite element modeling techniques in studying multiscale mechanobiology of bone are included. The second section focuses on mechanobiology more broadly in health and disease, spanning its role across bone, cartilage, the dental and periodontal tissues, muscle, the cornea and sclera, and in airways. Each chapter considers the molecular and cellular mechanisms of mechanotransduction in these areas, as well as its significance for associated physiological and pathological conditions. The final section examines novel technologies like high-resolution mechanical imaging, organoids and artificial intelligence, concluding with the translational potential of mechanomedicine and its therapeutic applications.

Mechanobiology and Mechanomedicine: From Fundamentals to Applications serves as a comprehensive and systematic overview of mechanobiology, sharing insights into the latest research advances and clinical relevance. Taking an interdisciplinary approach, this book is ideal for scientists, researchers and advanced students working across a range of areas including molecular biology, cell biology, translational medicine, biomechanics, biomedical engineering, biotechnology and related fields.

• Highlights recent discoveries in mechanobiology related to diverse physiological and pathological conditions
• Showcases innovative methods and technologies, including high-resolution mechanical imaging, organoids, and artificial intelligence integration
• Explores mechanomedicine and its role in advancing translational research and clinical therapies