Current Approaches to Overcome Therapeutic Resistance of Leukemia presents a comprehensive academic resource addressing the persistent challenge of treatment resistance in leukemia. It explores biological, molecular, and clinical dimensions of resistance, bridging fundamental research with therapeutic innovation. The book examines key resistance mechanisms, including genetic mutations, leukemic stem cells, and tumor microenvironment interactions, alongside emerging insights such as epigenetic regulation, metabolic reprogramming, and immune evasion. It further highlights advanced therapeutic approaches, including immunotherapy, targeted therapies, combination strategies, and AI-driven tools for drug discovery and monitoring. This volume provides students, researchers, and clinicians with foundational and integrated knowledge essential for understanding resistance biology and translating discoveries into clinical practice. It supports evidence-based decision-making and promotes the development of innovative strategies to improve patient outcomes.
- Bridges basic research and clinical translation by connecting mechanistic insights with therapeutic and future-oriented perspectives
- Integrates emerging therapeutic approaches such as CAR-T cell therapy, PROTAC-based strategies, combination therapies, and AI-enabled drug discovery
- Analyzes intrinsic and acquired resistance mechanisms, including genetic, epigenetic, metabolic, and microenvironment-driven processes in leukemia
