Fluorine and Health

Alain Tressaud is Emeritus Research Director at ICMCB-CNRS, Bordeaux University. He is President of the European Academy of Science in Brussels and member of several European academies. He founded and chaired the French Network on Fluorine Chemistry, sponsored by CNRS, until 2008. He has received several awards, including the CEA Award of French Academy of Sciences (2008), the Fluorine Award of the American Chemical Society (2011), and the International Henri Moissan Prize (2013). His scientific interest covers various fields, including synthesis, physical chemical characterizations, applications in fluorine chemistry, solid state chemistry, and materials sciences. His work also deals with surface modification of materials and intercalation chemistry. Professor Tressaud’s scientific production includes more than 360 papers in international journals, 20 book chapter contributions, and 12 internationalized patents. He has also edited several books in his role as editor-in-chief of the series “Advances in Fluorine Science” (2006) and “Progress in Fluorine Science” (2016) with Elsevier. Günter Haufe graduated from the University of Leipzig (Germany) with a Diploma degree in 1972 and a Dr. rer. nat. in 1975 both with Professor Manfred Mühlstädt. After basic military service he started his independent scientific career and did a Habilitation and venia legendi in Leipzig (1985). In 1986 he worked as a Research Fellow of Centre National de la Recherche Scientifique (CNRS) with André Laurent at the Université Lyon I (France) for 6 months, and as a visiting scientist with Jakko Paasivirta at the University of Jyväskylä (Finland). From 1988-1991 he was an Associate Professor (Docent) of Bioorganic Chemistry at the University of Leipzig before he was appointed at his present position as a Professor of Organic Chemistry at the University of Münster (Germany). Guest Professorships led him to Lyon, Poznan, Rouen, Valencia, Nagoya, Shanghai and to the University of Florida, Gainesville (USA) as a Paul Tarrant Visiting Professor. He was awarded with the “Friedrich-Wöhler-Preis” in 1985 and elected as a member of the European Academy of Sciences in 2015. From 2008-2010 he served as a Chair of the group of German fluorine chemists within the German Chemical Society. He published a book on "Alicyclic Chemistry" together with Gerhard Mann (1989) and edited a monograph "Fluorine and Health" together with Alain Tressaud (2008). He was an Associate Editor of "Advances in Fluorine Science" and is a Regional Editor of the Journal of Fluorine Chemistry since 2008.His research interest span from Organofluorine Chemistry, particularly fluorination methodology, selective synthesis of fluorinated analogues of natural products and 18F-tracers for the Positron-Emission-Tomography, via Preparative Organic Chemistry including total synthesis of natural products, to enzymatic methods for the preparation of organic compounds.

• PART I: MOLECULAR IMAGING1. Fluorine-18 Chemistry for Molecular Imaging with Positron Emission TomographyFrédéric Dollé, Dirk Roeda, Bertrand Kuhnast, and Marie-Claire Lasne2. Application of 18F-PET Imaging for the Study of Alzheimer’s Disease Kjell Någren and Juha O. Rinne3. 18F-Labeled PET-Tracers for Cardiological Imaging Klaus Kopka, Stefan Wagner, Michael Schäfers, Andreas Faust, Otmar Schober, and Günter Haufe4. [18F]-Labeled PET and PET/CT Compounds in Oncology Ken Herrmann and Bernd Joachim Krause5. Non-Invasive Physiology and Pharmacology Using 19F Magnetic Resonance Jian-Xin Yu, Weina Cui, Dawen Zhao, and Ralph P. MasonPART II: BIOMEDICAL MATERIALS6. Fluoride-Based Bioceramics Christian Rey, Christèle Combes, Christophe Drouet, and Hocine Sfihi7. Fluoride in Dentistry and Dental Restoratives John W. Nicholson and Beata Czarnecka8. Fluorinated Biomaterials for Cardiovascular Surgery Charles Baquey, Marie-Christine Durrieu, and Robert G. Guidoin9. Fluorinated Molecules in Eye Surgery: Experimental and Clinical Benefit of a Heavy Silicone Oil Oxane Hd® (Mixture of Silicone Oil and RMN3 Fluorine Olefin) in the Treatment of Retinal Detachment I. Rico-Lattes, J. C. Quintyn, V. Pagot-Mathis, X. Benouaich, and A. Mathis10. Biocompatibility of Highly Fluorinated Liquids Used in Ophthalmic Surgery Dirk-Henning Menz and Joachim H. Dresp11. Perfluorochemical-Based Oxygen Therapeutics, Contrast Agents, and Beyond Marie Pierre Krafft and Jean G. Riess12. Exposure of Humans to Fluorine and Its Assessment Maja PonikvarPART III: PHARMACEUTICALS13. Biological Impacts of Fluorination: Pharmaceuticals Based on Natural Products Jean-Pierre Bégué and Danièle Bonnet-Delpon14. Synthesis and Pharmacological Properties of Fluorinated Prostanoids Yasushi Matsumura15. Synthesis and Biochemical Evaluation of Fluorinated Monoamine Oxidase Inhibitors Kenneth L. Kirk, Shinichi Yoshida, and Günter Haufe16. Fluoroolefin Dipeptide Isosteres: Structure, Syntheses, and Applications John T. Welch17. Molecular Interactions of Fluorinated Amino Acids in a Native Polypeptide Environment Mario Salwiczek, Christian Jäckel, and Beate Koksch18. Biological Fluorination in Streptomyces cattleya: The Fluorinase Hai Deng, Fang-Lu Huang, James H. Naismith, David O′Hagan, Jonathan B. Spencer, and Xiaofeng Zhu