ZORAN RANKOVIC is a Senior Research Fellow and Associate Director in Medicinal Chemistry at Schering-Plough Research Institute, UK. He received his PhD in organic chemistry from the University of Leeds (UK) before starting his medicinal chemistry career in 1995 at Organon, UK. Since then, working on projects over a range of therapeutic areas, including psychosis, analgesia, and cardiovascular and bone diseases, he gained extensive experience in all stages of the drug discovery process, including lead generation. From this work, Dr. Rankovic has authored or coauthored over fifty scientific publications, book chapters, and patents, and has given invited lectures at numerous international conferences. RICHARD MORPHY is a medicinal chemistry section head at Schering-Plough Research Institute (SPRI) at Newhouse, Scotland. He has twenty years' experience in the pharmaceutical industry, previously working for Celltech and Organon on a wide range of oncology, inflammation, psychiatry, and analgesia projects. In addition to his extensive experience of the lead discovery process, he has a keen interest in the development of medicinal chemistry in emerging economies and is an opinion leader in the area of multi-target drug discovery.

"The book provides a comprehensive overview of many aspects of the lead generation process . . . The book delivers a good introduction to the process of lead generation for novice researchers. It is also useful for more experienced scientists to update their knowledge and/or to identify some new details." (ChemMedChem, October 2010) "This volume is recommended to chemists and biologists who wish to learn about the practice of high throughput screening and about the concepts involved in making the method a successful route to drug discovery." (Journal of Medicinal Chemistry, 2010)"Each chapter provides a comprehensive overview of one aspect of the lead generation process. To get more indepth knowledge, extensive references including recent publications are given." (ChemMedChem, 2010)

• PREFACE. CONTRIBUTORS.1 Lead Discovery: The Process (William F. Michne).2 High Throughput Screening Approach to Lead Discovery (Zoran Rankovic, Craig Jamieson, and Richard Morphy).3 In Silico Screening (Dagmar Stumpfe, Hanna Geppert, and Jürgen Bajorath).4 Fragment-Based Lead Discovery (Jeffrey S. Albert).5 Design of Multitarget Ligands (Richard Morphy and Zoran Rankovic).6 De novo Drug Design (Gisbert Schneider, Markus Hartenfeller, and Ewgenij Proschak).7 Role of Natural Products in Drug Discovery (Hugo Lachance, Stefan Wetzel, and Herbert Waldmann).8 Early Screening for ADMET Properties (Dennis A. Smith).9 Role of Chemistry in Lead Discovery (Roland E. Dolle and Karin Worm).INDEX.

ZORAN RANKOVIC is a Senior Research Fellow and Associate Director in Medicinal Chemistry at Schering-Plough Research Institute, UK. He received his PhD in organic chemistry from the University of Leeds (UK) before starting his medicinal chemistry career in 1995 at Organon, UK. Since then, working on projects over a range of therapeutic areas, including psychosis, analgesia, and cardiovascular and bone diseases, he gained extensive experience in all stages of the drug discovery process, including lead generation. From this work, Dr. Rankovic has authored or coauthored over fifty scientific publications, book chapters, and patents, and has given invited lectures at numerous international conferences. RICHARD MORPHY is a medicinal chemistry section head at Schering-Plough Research Institute (SPRI) at Newhouse, Scotland. He has twenty years' experience in the pharmaceutical industry, previously working for Celltech and Organon on a wide range of oncology, inflammation, psychiatry, and analgesia projects. In addition to his extensive experience of the lead discovery process, he has a keen interest in the development of medicinal chemistry in emerging economies and is an opinion leader in the area of multi-target drug discovery.

"The book provides a comprehensive overview of many aspects of the lead generation process . . . The book delivers a good introduction to the process of lead generation for novice researchers. It is also useful for more experienced scientists to update their knowledge and/or to identify some new details." (ChemMedChem, October 2010) "This volume is recommended to chemists and biologists who wish to learn about the practice of high throughput screening and about the concepts involved in making the method a successful route to drug discovery." (Journal of Medicinal Chemistry, 2010)"Each chapter provides a comprehensive overview of one aspect of the lead generation process. To get more indepth knowledge, extensive references including recent publications are given." (ChemMedChem, 2010)

• PREFACE. CONTRIBUTORS.1 Lead Discovery: The Process (William F. Michne).2 High Throughput Screening Approach to Lead Discovery (Zoran Rankovic, Craig Jamieson, and Richard Morphy).3 In Silico Screening (Dagmar Stumpfe, Hanna Geppert, and Jürgen Bajorath).4 Fragment-Based Lead Discovery (Jeffrey S. Albert).5 Design of Multitarget Ligands (Richard Morphy and Zoran Rankovic).6 De novo Drug Design (Gisbert Schneider, Markus Hartenfeller, and Ewgenij Proschak).7 Role of Natural Products in Drug Discovery (Hugo Lachance, Stefan Wetzel, and Herbert Waldmann).8 Early Screening for ADMET Properties (Dennis A. Smith).9 Role of Chemistry in Lead Discovery (Roland E. Dolle and Karin Worm).INDEX.

ZORAN RANKOVIC is a Senior Research Fellow and Associate Director in Medicinal Chemistry at Schering-Plough Research Institute, UK. He received his PhD in organic chemistry from the University of Leeds (UK) before starting his medicinal chemistry career in 1995 at Organon, UK. Since then, working on projects over a range of therapeutic areas, including psychosis, analgesia, and cardiovascular and bone diseases, he gained extensive experience in all stages of the drug discovery process, including lead generation. From this work, Dr. Rankovic has authored or coauthored over fifty scientific publications, book chapters, and patents, and has given invited lectures at numerous international conferences. RICHARD MORPHY is a medicinal chemistry section head at Schering-Plough Research Institute (SPRI) at Newhouse, Scotland. He has twenty years' experience in the pharmaceutical industry, previously working for Celltech and Organon on a wide range of oncology, inflammation, psychiatry, and analgesia projects. In addition to his extensive experience of the lead discovery process, he has a keen interest in the development of medicinal chemistry in emerging economies and is an opinion leader in the area of multi-target drug discovery.

"The book provides a comprehensive overview of many aspects of the lead generation process . . . The book delivers a good introduction to the process of lead generation for novice researchers. It is also useful for more experienced scientists to update their knowledge and/or to identify some new details." (ChemMedChem, October 2010) "This volume is recommended to chemists and biologists who wish to learn about the practice of high throughput screening and about the concepts involved in making the method a successful route to drug discovery." (Journal of Medicinal Chemistry, 2010)"Each chapter provides a comprehensive overview of one aspect of the lead generation process. To get more indepth knowledge, extensive references including recent publications are given." (ChemMedChem, 2010)

• PREFACE. CONTRIBUTORS.1 Lead Discovery: The Process (William F. Michne).2 High Throughput Screening Approach to Lead Discovery (Zoran Rankovic, Craig Jamieson, and Richard Morphy).3 In Silico Screening (Dagmar Stumpfe, Hanna Geppert, and Jürgen Bajorath).4 Fragment-Based Lead Discovery (Jeffrey S. Albert).5 Design of Multitarget Ligands (Richard Morphy and Zoran Rankovic).6 De novo Drug Design (Gisbert Schneider, Markus Hartenfeller, and Ewgenij Proschak).7 Role of Natural Products in Drug Discovery (Hugo Lachance, Stefan Wetzel, and Herbert Waldmann).8 Early Screening for ADMET Properties (Dennis A. Smith).9 Role of Chemistry in Lead Discovery (Roland E. Dolle and Karin Worm).INDEX.