Viral Oncology

Kamel Khalili, PhD, Professor and Chair, Department of Neuroscience, Temple University, and Kuan-Teh Jeang, MD, PhD, Head, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, NIH, are among the leading scientists in the field of human DNA and RNA viruses. Each of them has more than 25 years' experience in studying oncogenic viruses.

"The book is addressed to medical students as well as clinical scientists and students of molecular biology. In a rapidly growing field it is a great advantage to have all this valuable information in one volume." (Journal Tropical Ped, 2012) "I would recommend this book to all interested in the role that viruses play in cancer development, students and experienced researchers alike." (Society for General Microbiology, July 2010)

• Foreword viiPreface xiContributors xiii1 HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS 1Rachel A. Katzenellenbogen and Denise A. Galloway2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS 23Amy Baldwin and Karl Münger3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57Miranda Thomas, David Pim, and Lawrence Banks4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89Krzysztof Reiss, Kamel Khalili, and Luis Del Valle5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113C. Richard Boland, Luigi Ricciardiello, and Ajay Goel6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129Michael J. Imperiale and Dweepanita Das7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149Abhilasha V. Rathi and James M. Pipas8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165Janet S. Butel9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191Natalya Baranova and Michele Carbone10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER 211Timothy M. Block and Anand S. Mehta11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225Mei-Hwei Chang and Ding-Shinn Chen12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243Mark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION 267Donna Sir and Jing-Hsiung James Ou14 CLINICAL ASPECTS OF HTLV-1-ASSOCIATED CANCER 279Masao Matsuoka15 ONCOGENIC POTENTIAL OF THE HTLV-1 TAX PROTEIN 295Susan J. Marriott16 HIV-1-ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317Melissa Agsalda and Bruce Shiramizu17 HIV-RELATED LYMPHOMA 337Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini18 BIOLOGY AND EPIDEMIOLOGY OF HHV-8 351Veenu Minhas and Charles Wood19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI’S SARCOMA 377Gary S. Hayward, Donald J. Alcendor, and Ravit Arav-Boger20 MOLECULAR PATHOBIOLOGY OF EBV INFECTION 409Joseph S. Pagano21 EPSTEIN–BARR VIRUS AS A PATHOGEN 425Wasim A. Dar and Bill SugdenIndex 453