Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis. Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include: the principles of solid phase organic synthesiselectrophile and nucleophile cleavable linker unitscyclative cleavage as a solid phase strategyphotocleavable linker unitssafety-catch linker unitsenzyme cleavable linker unitsT1 and T2 –versatile triazene linker groupshydrazone linker unitsbenzotriazole linker unitsphosphorus linker unitssulfur linker unitsselenium and tellurium linker unitssulfur, oxygen and selenium linker units cleaved by radical processessilicon and germanium linker unitsboron and stannane linker unitsbismuth linker unitstransition metal carbonyl linker unitslinkers releasing olefins or cycloolefins by ring-closing metathesisfluorous linker unitssolid-phase radiochemistryThe book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis.Linker Strategies in Solid-Phase Organic Synthesis is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.
