Copper-Oxygen Chemistry

Kenneth D. Karlin is Ira Remsen Professor of Chemistry at Johns Hopkins University. His bioinorganic research focuses on coordination chemistry relevant to biological and environmental processes, involving copper or heme (porphyrin-iron) complexes. Dr. Karlin's main approach involves synthetic modeling, i.e., biomimetic chemistry. He is the winner of the prestigious F. Albert Cotton Award in Synthetic Inorganic Chemistry and the Sierra Nevada Distinguished Chemist Award, both awarded in 2009. Shinobu Itoh focuses his current research on chemical modeling and application of novel active sites in biological systems. He was formerly an assistant professor at Osaka University, where he worked on the chemistry of coenzyme PQQ and cofactor TTQ as well as model compounds of galactose oxidase. In 1994, he was promoted to associate professor at Osaka University, where he collaborated with Professor Shunichi Fukuzumi in copper-dioxygen chemistry research. In 1999, he moved to Osaka City University as a full professor and started biological studies of dinuclear copper proteins, such as hemocyanin and tyrosinase. He returned to Osaka University in 2008 and further expanded his research interests to the design of artificial non-heme metalloenzymes using genetic engineering.

• Preface to Series vii Introduction ixContributors xi1 Insights into the Proposed Copper–Oxygen Intermediates that Regulate the Mechanism of Reactions Catalyzed by Dopamine b-Monooxygenase, Peptidylglycine a-Hydroxylating Monooxygenase, and Tyramine b-Monooxygenase 1Robert L. Osborne and Judith P. Klinman2 Copper Dioxygenases 23Jozsef Kaizer, Jozsef Sandor Pap, and Gabor Speier3 Amine Oxidase and Galactose Oxidase 53Dalia Rokhsana, Eric M. Shepard, Doreen E. Brown, and David M. Dooley4 Energy Conversion and Conservation by Cytochrome Oxidases 107Angela Paulus and Simon de Vries5 Multicopper Proteins 131Takeshi Sakurai and Kunishige Kataoka6 Structure and Reactivity of Copper–Oxygen Species Revealed by Competitive Oxygen-18 Isotope Effects 169Justine P. Roth7 Theoretical Aspects of Dioxygen Activation in Dicopper Enzymes 197Kazunari Yoshizawa8 Chemical Reactivity of Copper Active-Oxygen Complexes 225Shinobu Itoh9 Cytochrome c Oxidase and Models 283Zakaria Halime and Kenneth D. Karlin10 Supramolecular Copper Dioxygen Chemistry 321Jean-Noel Rebilly and Olivia Reinaud11 Organic Synthetic Methods Using Copper Oxygen Chemistry 361Marisa C. KozlowskiIndex 445