Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998. Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University.Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research.Robert W. Woody is an Emeritus Professor at Colorado State University.

“Well-trained scientists and postgraduate students will benefit a lot from using it. The set should survive for years to come, because it is unlikely that the scientific community will see anything like it for a while.”  (Angewandte Chemie, 1 September 2012)

• Comprehensive Chiroptical Spectroscopy, Volume 1 PREFACE ixCONTRIBUTORS xiPART I INTRODUCTION 11 ON THE INTERACTION OF LIGHT WITH MOLECULES: PATHWAYS TO THE THEORETICAL INTERPRETATION OF CHIROPTICAL PHENOMENA 3Georges H. WagnièrePART II EXPERIMENTAL METHODSANDINSTRUMENTATION 352 MEASUREMENT OF THE CIRCULAR DICHROISM OF ELECTRONIC TRANSITIONS 37John C. Sutherland3 CIRCULARLY POLARIZED LUMINESCENCE SPECTROSCOPY AND EMISSION-DETECTED CIRCULAR DICHROISM 65James P. Riehl and Gilles Muller4 SOLID-STATE CHIROPTICAL SPECTROSCOPY: PRINCIPLES AND APPLICATIONS 91Reiko Kuroda and Takunori Harada5 INFRARED VIBRATIONAL OPTICAL ACTIVITY: MEASUREMENT AND INSTRUMENTATION 115Laurence A. Nafie6 MEASUREMENT OF RAMAN OPTICAL ACTIVITY 147Werner Hug7 NANOSECOND TIME-RESOLVED NATURAL AND MAGNETIC CHIROPTICAL SPECTROSCOPIES 179David S. Kliger, Eefei Chen, and Robert A. Goldbeck8 FEMTOSECOND INFRARED CIRCULAR DICHROISM AND OPTICAL ROTATORY DISPERSION 203Hanju Rhee and Minhaeng Cho9 CHIROPTICAL PROPERTIES OF LANTHANIDE COMPOUNDS IN AN EXTENDED WAVELENGTH RANGE 221Lorenzo Di Bari and Piero Salvadori10 NEAR-INFRARED VIBRATIONAL CIRCULAR DICHROISM: NIR-VCD 247Sergio Abbate, Giovanna Longhi, and Ettore Castiglioni11 OPTICAL ROTATION AND INTRINSIC OPTICAL ACTIVITY 275Patrick H. Vaccaro12 CHIROPTICAL IMAGING OF CRYSTALS 325John Freudenthal, Werner Kaminsky, and Bart Kahr13 NONLINEAR OPTICAL SPECTROSCOPY OF CHIRAL MOLECULES 347Peer Fischer14 IN SITU MEASUREMENT OF CHIRALITY OF MOLECULES AND MOLECULAR ASSEMBLIES WITH SURFACE NONLINEAR SPECTROSCOPY 373Hong-fei Wang15 PHOTOELECTRON CIRCULAR DICHROISM 407Ivan Powis16 MAGNETOCHIRAL DICHROISM AND BIREFRINGENCE 433G. L. J. A. Rikken17 X-RAY DETECTED OPTICAL ACTIVITY 457Jose Goulon, Andrei Rogalev, and Christian Brouder18 LINEAR DICHROISM 493Alison Rodger19 ELECTRO-OPTICAL ABSORPTION SPECTROSCOPY 525Hans-Georg Kuball and Matthias StoltePART III THEORETICAL SIMULATIONS 54120 INDEPENDENT SYSTEMS THEORY FOR PREDICTING ELECTRONIC CIRCULAR DICHROISM 543Gerhard Raabe, Joerg Fleischhauer, and Robert W. Woody21 AB INITIO ELECTRONIC CIRCULAR DICHROISM AND OPTICAL ROTATORY DISPERSION: FROM ORGANIC MOLECULES TO TRANSITION METAL COMPLEXES 593Jochen Autschbach22 THEORETICAL ELECTRONIC CIRCULAR DICHROISM SPECTROSCOPY OF LARGE ORGANIC AND SUPRAMOLECULAR SYSTEMS 643Lars Goerigk, Holger Kruse, and Stefan Grimme23 HIGH-ACCURACY QUANTUM CHEMISTRY AND CHIROPTICAL PROPERTIES 675T. Daniel Crawford24 AB INITIO METHODS FOR VIBRATIONAL CIRCULAR DICHROISM AND RAMAN OPTICAL ACTIVITY 699Kenneth Ruud25 MODELING OF SOLVATION EFFECTS ON CHIROPTICAL SPECTRA 729Magdalena Pecul26 COMPLEXATION, SOLVATION, AND CHIRALITY TRANSFER IN VIBRATIONAL CIRCULAR DICHROISM 747Valentin Paul Nicu and Evert Jan BaerendsINDEX 783Comprehensive Chiroptical Spectroscopy, Volume 2PREFACE xiCONTRIBUTORS xiiiPART I A HISTORICAL OVERVIEW 11 THE FIRST DECADES AFTER THE DISCOVERY OF CD AND ORD BY AIME COTTON IN 1895 3Peter LaurPART II ORGANIC STEREOCHEMISTRY 372 SOME INHERENTLY CHIRAL CHROMOPHORES—EMPIRICAL RULES AND QUANTUM CHEMICAL CALCULATIONS 39Marcin Kwit, Pawel Skowronek, Jacek Gawronski, Jadwiga Frelek, Magdalena Woznica, and Aleksandra Butkiewicz3 ELECTRONIC CD OF BENZENE AND OTHER AROMATIC CHROMOPHORES FOR DETERMINATION OF ABSOLUTE CONFIGURATION 73Tibor Kurtan, Sandor Antus, and Gennaro Pescitelli4 ELECTRONIC CD EXCITON CHIRALITY METHOD: PRINCIPLES AND APPLICATIONS 115Nobuyuki Harada, Koji Nakanishi, and Nina Berova5 CD SPECTRA OF CHIRAL EXTENDED p-ELECTRON COMPOUNDS: THEORETICAL DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY AND EXPERIMENTAL VERIFICATION 167Nobuyuki Harada and Shunsuke Kuwahara6 ASSIGNMENT OF THE ABSOLUTE CONFIGURATIONS OF NATURAL PRODUCTS BY MEANS OF SOLID-STATE ELECTRONIC CIRCULAR DICHROISM AND QUANTUM MECHANICAL CALCULATIONS 217Gennaro Pescitelli, Tibor Kurtan, and Karsten Krohn7 DYNAMIC STEREOCHEMISTRY AND CHIROPTICAL SPECTROSCOPY OF METALLO-ORGANIC COMPOUNDS 251James W. Canary and Zhaohua Dai8 CIRCULAR DICHROISM OF DYNAMIC SYSTEMS: SWITCHING MOLECULAR AND SUPRAMOLECULAR CHIRALITY 289Angela Mammana, Gregory T. Carroll, and Ben L. Feringa9 ELECTRONIC CIRCULAR DICHROISM OF SUPRAMOLECULAR SYSTEMS 317Cheng Yang and Yoshihisa Inoue10 THE ONLINE STEREOCHEMICAL ANALYSIS OF CHIRAL COMPOUNDS BY HPLC-ECD COUPLING IN COMBINATION WITH QUANTUM-CHEMICAL CALCULATIONS 355Gerhard Bringmann, Daniel Gotz, and Torsten Bruhn11 DETERMINATION OF THE STRUCTURES OF CHIRAL NATURAL PRODUCTS USING VIBRATIONAL CIRCULAR DICHROISM 387Prasad L. Polavarapu12 DETERMINATION OF MOLECULAR ABSOLUTE CONFIGURATION: GUIDELINES FOR SELECTING A SUITABLE CHIROPTICAL APPROACH 421Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo, and Egidio GiorgioPART III INORGANIC STEREOCHEMISTRY 44913 APPLICATIONS OF ELECTRONIC CIRCULAR DICHROISM TO INORGANIC STEREOCHEMISTRY 451Sumio KaizakiPART IV BIOMOLECULES 47314 ELECTRONIC CIRCULAR DICHROISM OF PROTEINS 475Robert W. Woody15 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDES 499Claudio Toniolo, Fernando Formaggio, and Robert W. Woody16 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDOMIMETICS 545Claudio Toniolo and Fernando Formaggio17 CIRCULAR DICHROISM SPECTROSCOPY OF NUCLEIC ACIDS 575Jaroslav Kypr, Iva Kejnovska, Klara Bednarova, and Michaela Vorlickova18 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDE NUCLEIC ACIDS AND THEIR ANALOGUES 587Roberto Corradini, Tullia Tedeschi, Stefano Sforza, and Rosangela Marchelli19 CIRCULAR DICHROISM OF PROTEIN–NUCLEIC ACID INTERACTIONS 615Donald M. Gray20 DRUG AND NATURAL PRODUCT BINDING TO NUCLEIC ACIDS ANALYZED BY ELECTRONIC CIRCULAR DICHROISM 635George A. Ellestad21 PROBING HSA AND AGP DRUG-BINDING SITES BY ELECTRONIC CIRCULAR DICHROISM 665Miklos Simonyi22 CONFORMATIONAL STUDIES OF BIOPOLYMERS, PEPTIDES, PROTEINS, AND NUCLEIC ACIDS. A ROLE FOR VIBRATIONAL CIRCULAR DICHROISM 707Timothy A. Keiderling and Ahmed Lakhani23 STRUCTURE AND BEHAVIOR OF BIOMOLECULES FROM RAMAN OPTICAL ACTIVITY 759Laurence D. Barron and Lutz Hecht24 OPTICAL ROTATION, ELECTRONIC CIRCULAR DICHROISM, AND VIBRATIONAL CIRCULAR DICHROISM OF CARBOHYDRATES AND GLYCOCONJUGATES 795Tohru Taniguchi and Kenji Monde25 ELECTRONIC CIRCULAR DICHROISM IN DRUG DISCOVERY 819Carlo Bertucci and Marco PistolozziINDEX 843

Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998. Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University.Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research.Robert W. Woody is an Emeritus Professor at Colorado State University.

“Well-trained scientists and postgraduate students will benefit a lot from using it. The set should survive for years to come, because it is unlikely that the scientific community will see anything like it for a while.”  (Angewandte Chemie, 1 September 2012)

• Comprehensive Chiroptical Spectroscopy, Volume 1 PREFACE ixCONTRIBUTORS xiPART I INTRODUCTION 11 ON THE INTERACTION OF LIGHT WITH MOLECULES: PATHWAYS TO THE THEORETICAL INTERPRETATION OF CHIROPTICAL PHENOMENA 3Georges H. WagnièrePART II EXPERIMENTAL METHODSANDINSTRUMENTATION 352 MEASUREMENT OF THE CIRCULAR DICHROISM OF ELECTRONIC TRANSITIONS 37John C. Sutherland3 CIRCULARLY POLARIZED LUMINESCENCE SPECTROSCOPY AND EMISSION-DETECTED CIRCULAR DICHROISM 65James P. Riehl and Gilles Muller4 SOLID-STATE CHIROPTICAL SPECTROSCOPY: PRINCIPLES AND APPLICATIONS 91Reiko Kuroda and Takunori Harada5 INFRARED VIBRATIONAL OPTICAL ACTIVITY: MEASUREMENT AND INSTRUMENTATION 115Laurence A. Nafie6 MEASUREMENT OF RAMAN OPTICAL ACTIVITY 147Werner Hug7 NANOSECOND TIME-RESOLVED NATURAL AND MAGNETIC CHIROPTICAL SPECTROSCOPIES 179David S. Kliger, Eefei Chen, and Robert A. Goldbeck8 FEMTOSECOND INFRARED CIRCULAR DICHROISM AND OPTICAL ROTATORY DISPERSION 203Hanju Rhee and Minhaeng Cho9 CHIROPTICAL PROPERTIES OF LANTHANIDE COMPOUNDS IN AN EXTENDED WAVELENGTH RANGE 221Lorenzo Di Bari and Piero Salvadori10 NEAR-INFRARED VIBRATIONAL CIRCULAR DICHROISM: NIR-VCD 247Sergio Abbate, Giovanna Longhi, and Ettore Castiglioni11 OPTICAL ROTATION AND INTRINSIC OPTICAL ACTIVITY 275Patrick H. Vaccaro12 CHIROPTICAL IMAGING OF CRYSTALS 325John Freudenthal, Werner Kaminsky, and Bart Kahr13 NONLINEAR OPTICAL SPECTROSCOPY OF CHIRAL MOLECULES 347Peer Fischer14 IN SITU MEASUREMENT OF CHIRALITY OF MOLECULES AND MOLECULAR ASSEMBLIES WITH SURFACE NONLINEAR SPECTROSCOPY 373Hong-fei Wang15 PHOTOELECTRON CIRCULAR DICHROISM 407Ivan Powis16 MAGNETOCHIRAL DICHROISM AND BIREFRINGENCE 433G. L. J. A. Rikken17 X-RAY DETECTED OPTICAL ACTIVITY 457Jose Goulon, Andrei Rogalev, and Christian Brouder18 LINEAR DICHROISM 493Alison Rodger19 ELECTRO-OPTICAL ABSORPTION SPECTROSCOPY 525Hans-Georg Kuball and Matthias StoltePART III THEORETICAL SIMULATIONS 54120 INDEPENDENT SYSTEMS THEORY FOR PREDICTING ELECTRONIC CIRCULAR DICHROISM 543Gerhard Raabe, Joerg Fleischhauer, and Robert W. Woody21 AB INITIO ELECTRONIC CIRCULAR DICHROISM AND OPTICAL ROTATORY DISPERSION: FROM ORGANIC MOLECULES TO TRANSITION METAL COMPLEXES 593Jochen Autschbach22 THEORETICAL ELECTRONIC CIRCULAR DICHROISM SPECTROSCOPY OF LARGE ORGANIC AND SUPRAMOLECULAR SYSTEMS 643Lars Goerigk, Holger Kruse, and Stefan Grimme23 HIGH-ACCURACY QUANTUM CHEMISTRY AND CHIROPTICAL PROPERTIES 675T. Daniel Crawford24 AB INITIO METHODS FOR VIBRATIONAL CIRCULAR DICHROISM AND RAMAN OPTICAL ACTIVITY 699Kenneth Ruud25 MODELING OF SOLVATION EFFECTS ON CHIROPTICAL SPECTRA 729Magdalena Pecul26 COMPLEXATION, SOLVATION, AND CHIRALITY TRANSFER IN VIBRATIONAL CIRCULAR DICHROISM 747Valentin Paul Nicu and Evert Jan BaerendsINDEX 783Comprehensive Chiroptical Spectroscopy, Volume 2PREFACE xiCONTRIBUTORS xiiiPART I A HISTORICAL OVERVIEW 11 THE FIRST DECADES AFTER THE DISCOVERY OF CD AND ORD BY AIME COTTON IN 1895 3Peter LaurPART II ORGANIC STEREOCHEMISTRY 372 SOME INHERENTLY CHIRAL CHROMOPHORES—EMPIRICAL RULES AND QUANTUM CHEMICAL CALCULATIONS 39Marcin Kwit, Pawel Skowronek, Jacek Gawronski, Jadwiga Frelek, Magdalena Woznica, and Aleksandra Butkiewicz3 ELECTRONIC CD OF BENZENE AND OTHER AROMATIC CHROMOPHORES FOR DETERMINATION OF ABSOLUTE CONFIGURATION 73Tibor Kurtan, Sandor Antus, and Gennaro Pescitelli4 ELECTRONIC CD EXCITON CHIRALITY METHOD: PRINCIPLES AND APPLICATIONS 115Nobuyuki Harada, Koji Nakanishi, and Nina Berova5 CD SPECTRA OF CHIRAL EXTENDED p-ELECTRON COMPOUNDS: THEORETICAL DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY AND EXPERIMENTAL VERIFICATION 167Nobuyuki Harada and Shunsuke Kuwahara6 ASSIGNMENT OF THE ABSOLUTE CONFIGURATIONS OF NATURAL PRODUCTS BY MEANS OF SOLID-STATE ELECTRONIC CIRCULAR DICHROISM AND QUANTUM MECHANICAL CALCULATIONS 217Gennaro Pescitelli, Tibor Kurtan, and Karsten Krohn7 DYNAMIC STEREOCHEMISTRY AND CHIROPTICAL SPECTROSCOPY OF METALLO-ORGANIC COMPOUNDS 251James W. Canary and Zhaohua Dai8 CIRCULAR DICHROISM OF DYNAMIC SYSTEMS: SWITCHING MOLECULAR AND SUPRAMOLECULAR CHIRALITY 289Angela Mammana, Gregory T. Carroll, and Ben L. Feringa9 ELECTRONIC CIRCULAR DICHROISM OF SUPRAMOLECULAR SYSTEMS 317Cheng Yang and Yoshihisa Inoue10 THE ONLINE STEREOCHEMICAL ANALYSIS OF CHIRAL COMPOUNDS BY HPLC-ECD COUPLING IN COMBINATION WITH QUANTUM-CHEMICAL CALCULATIONS 355Gerhard Bringmann, Daniel Gotz, and Torsten Bruhn11 DETERMINATION OF THE STRUCTURES OF CHIRAL NATURAL PRODUCTS USING VIBRATIONAL CIRCULAR DICHROISM 387Prasad L. Polavarapu12 DETERMINATION OF MOLECULAR ABSOLUTE CONFIGURATION: GUIDELINES FOR SELECTING A SUITABLE CHIROPTICAL APPROACH 421Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo, and Egidio GiorgioPART III INORGANIC STEREOCHEMISTRY 44913 APPLICATIONS OF ELECTRONIC CIRCULAR DICHROISM TO INORGANIC STEREOCHEMISTRY 451Sumio KaizakiPART IV BIOMOLECULES 47314 ELECTRONIC CIRCULAR DICHROISM OF PROTEINS 475Robert W. Woody15 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDES 499Claudio Toniolo, Fernando Formaggio, and Robert W. Woody16 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDOMIMETICS 545Claudio Toniolo and Fernando Formaggio17 CIRCULAR DICHROISM SPECTROSCOPY OF NUCLEIC ACIDS 575Jaroslav Kypr, Iva Kejnovska, Klara Bednarova, and Michaela Vorlickova18 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDE NUCLEIC ACIDS AND THEIR ANALOGUES 587Roberto Corradini, Tullia Tedeschi, Stefano Sforza, and Rosangela Marchelli19 CIRCULAR DICHROISM OF PROTEIN–NUCLEIC ACID INTERACTIONS 615Donald M. Gray20 DRUG AND NATURAL PRODUCT BINDING TO NUCLEIC ACIDS ANALYZED BY ELECTRONIC CIRCULAR DICHROISM 635George A. Ellestad21 PROBING HSA AND AGP DRUG-BINDING SITES BY ELECTRONIC CIRCULAR DICHROISM 665Miklos Simonyi22 CONFORMATIONAL STUDIES OF BIOPOLYMERS, PEPTIDES, PROTEINS, AND NUCLEIC ACIDS. A ROLE FOR VIBRATIONAL CIRCULAR DICHROISM 707Timothy A. Keiderling and Ahmed Lakhani23 STRUCTURE AND BEHAVIOR OF BIOMOLECULES FROM RAMAN OPTICAL ACTIVITY 759Laurence D. Barron and Lutz Hecht24 OPTICAL ROTATION, ELECTRONIC CIRCULAR DICHROISM, AND VIBRATIONAL CIRCULAR DICHROISM OF CARBOHYDRATES AND GLYCOCONJUGATES 795Tohru Taniguchi and Kenji Monde25 ELECTRONIC CIRCULAR DICHROISM IN DRUG DISCOVERY 819Carlo Bertucci and Marco PistolozziINDEX 843

Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998. Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University.Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research.Robert W. Woody is an Emeritus Professor at Colorado State University.

“Well-trained scientists and postgraduate students will benefit a lot from using it. The set should survive for years to come, because it is unlikely that the scientific community will see anything like it for a while.”  (Angewandte Chemie, 1 September 2012)

• Comprehensive Chiroptical Spectroscopy, Volume 1 PREFACE ixCONTRIBUTORS xiPART I INTRODUCTION 11 ON THE INTERACTION OF LIGHT WITH MOLECULES: PATHWAYS TO THE THEORETICAL INTERPRETATION OF CHIROPTICAL PHENOMENA 3Georges H. WagnièrePART II EXPERIMENTAL METHODSANDINSTRUMENTATION 352 MEASUREMENT OF THE CIRCULAR DICHROISM OF ELECTRONIC TRANSITIONS 37John C. Sutherland3 CIRCULARLY POLARIZED LUMINESCENCE SPECTROSCOPY AND EMISSION-DETECTED CIRCULAR DICHROISM 65James P. Riehl and Gilles Muller4 SOLID-STATE CHIROPTICAL SPECTROSCOPY: PRINCIPLES AND APPLICATIONS 91Reiko Kuroda and Takunori Harada5 INFRARED VIBRATIONAL OPTICAL ACTIVITY: MEASUREMENT AND INSTRUMENTATION 115Laurence A. Nafie6 MEASUREMENT OF RAMAN OPTICAL ACTIVITY 147Werner Hug7 NANOSECOND TIME-RESOLVED NATURAL AND MAGNETIC CHIROPTICAL SPECTROSCOPIES 179David S. Kliger, Eefei Chen, and Robert A. Goldbeck8 FEMTOSECOND INFRARED CIRCULAR DICHROISM AND OPTICAL ROTATORY DISPERSION 203Hanju Rhee and Minhaeng Cho9 CHIROPTICAL PROPERTIES OF LANTHANIDE COMPOUNDS IN AN EXTENDED WAVELENGTH RANGE 221Lorenzo Di Bari and Piero Salvadori10 NEAR-INFRARED VIBRATIONAL CIRCULAR DICHROISM: NIR-VCD 247Sergio Abbate, Giovanna Longhi, and Ettore Castiglioni11 OPTICAL ROTATION AND INTRINSIC OPTICAL ACTIVITY 275Patrick H. Vaccaro12 CHIROPTICAL IMAGING OF CRYSTALS 325John Freudenthal, Werner Kaminsky, and Bart Kahr13 NONLINEAR OPTICAL SPECTROSCOPY OF CHIRAL MOLECULES 347Peer Fischer14 IN SITU MEASUREMENT OF CHIRALITY OF MOLECULES AND MOLECULAR ASSEMBLIES WITH SURFACE NONLINEAR SPECTROSCOPY 373Hong-fei Wang15 PHOTOELECTRON CIRCULAR DICHROISM 407Ivan Powis16 MAGNETOCHIRAL DICHROISM AND BIREFRINGENCE 433G. L. J. A. Rikken17 X-RAY DETECTED OPTICAL ACTIVITY 457Jose Goulon, Andrei Rogalev, and Christian Brouder18 LINEAR DICHROISM 493Alison Rodger19 ELECTRO-OPTICAL ABSORPTION SPECTROSCOPY 525Hans-Georg Kuball and Matthias StoltePART III THEORETICAL SIMULATIONS 54120 INDEPENDENT SYSTEMS THEORY FOR PREDICTING ELECTRONIC CIRCULAR DICHROISM 543Gerhard Raabe, Joerg Fleischhauer, and Robert W. Woody21 AB INITIO ELECTRONIC CIRCULAR DICHROISM AND OPTICAL ROTATORY DISPERSION: FROM ORGANIC MOLECULES TO TRANSITION METAL COMPLEXES 593Jochen Autschbach22 THEORETICAL ELECTRONIC CIRCULAR DICHROISM SPECTROSCOPY OF LARGE ORGANIC AND SUPRAMOLECULAR SYSTEMS 643Lars Goerigk, Holger Kruse, and Stefan Grimme23 HIGH-ACCURACY QUANTUM CHEMISTRY AND CHIROPTICAL PROPERTIES 675T. Daniel Crawford24 AB INITIO METHODS FOR VIBRATIONAL CIRCULAR DICHROISM AND RAMAN OPTICAL ACTIVITY 699Kenneth Ruud25 MODELING OF SOLVATION EFFECTS ON CHIROPTICAL SPECTRA 729Magdalena Pecul26 COMPLEXATION, SOLVATION, AND CHIRALITY TRANSFER IN VIBRATIONAL CIRCULAR DICHROISM 747Valentin Paul Nicu and Evert Jan BaerendsINDEX 783Comprehensive Chiroptical Spectroscopy, Volume 2PREFACE xiCONTRIBUTORS xiiiPART I A HISTORICAL OVERVIEW 11 THE FIRST DECADES AFTER THE DISCOVERY OF CD AND ORD BY AIME COTTON IN 1895 3Peter LaurPART II ORGANIC STEREOCHEMISTRY 372 SOME INHERENTLY CHIRAL CHROMOPHORES—EMPIRICAL RULES AND QUANTUM CHEMICAL CALCULATIONS 39Marcin Kwit, Pawel Skowronek, Jacek Gawronski, Jadwiga Frelek, Magdalena Woznica, and Aleksandra Butkiewicz3 ELECTRONIC CD OF BENZENE AND OTHER AROMATIC CHROMOPHORES FOR DETERMINATION OF ABSOLUTE CONFIGURATION 73Tibor Kurtan, Sandor Antus, and Gennaro Pescitelli4 ELECTRONIC CD EXCITON CHIRALITY METHOD: PRINCIPLES AND APPLICATIONS 115Nobuyuki Harada, Koji Nakanishi, and Nina Berova5 CD SPECTRA OF CHIRAL EXTENDED p-ELECTRON COMPOUNDS: THEORETICAL DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY AND EXPERIMENTAL VERIFICATION 167Nobuyuki Harada and Shunsuke Kuwahara6 ASSIGNMENT OF THE ABSOLUTE CONFIGURATIONS OF NATURAL PRODUCTS BY MEANS OF SOLID-STATE ELECTRONIC CIRCULAR DICHROISM AND QUANTUM MECHANICAL CALCULATIONS 217Gennaro Pescitelli, Tibor Kurtan, and Karsten Krohn7 DYNAMIC STEREOCHEMISTRY AND CHIROPTICAL SPECTROSCOPY OF METALLO-ORGANIC COMPOUNDS 251James W. Canary and Zhaohua Dai8 CIRCULAR DICHROISM OF DYNAMIC SYSTEMS: SWITCHING MOLECULAR AND SUPRAMOLECULAR CHIRALITY 289Angela Mammana, Gregory T. Carroll, and Ben L. Feringa9 ELECTRONIC CIRCULAR DICHROISM OF SUPRAMOLECULAR SYSTEMS 317Cheng Yang and Yoshihisa Inoue10 THE ONLINE STEREOCHEMICAL ANALYSIS OF CHIRAL COMPOUNDS BY HPLC-ECD COUPLING IN COMBINATION WITH QUANTUM-CHEMICAL CALCULATIONS 355Gerhard Bringmann, Daniel Gotz, and Torsten Bruhn11 DETERMINATION OF THE STRUCTURES OF CHIRAL NATURAL PRODUCTS USING VIBRATIONAL CIRCULAR DICHROISM 387Prasad L. Polavarapu12 DETERMINATION OF MOLECULAR ABSOLUTE CONFIGURATION: GUIDELINES FOR SELECTING A SUITABLE CHIROPTICAL APPROACH 421Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo, and Egidio GiorgioPART III INORGANIC STEREOCHEMISTRY 44913 APPLICATIONS OF ELECTRONIC CIRCULAR DICHROISM TO INORGANIC STEREOCHEMISTRY 451Sumio KaizakiPART IV BIOMOLECULES 47314 ELECTRONIC CIRCULAR DICHROISM OF PROTEINS 475Robert W. Woody15 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDES 499Claudio Toniolo, Fernando Formaggio, and Robert W. Woody16 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDOMIMETICS 545Claudio Toniolo and Fernando Formaggio17 CIRCULAR DICHROISM SPECTROSCOPY OF NUCLEIC ACIDS 575Jaroslav Kypr, Iva Kejnovska, Klara Bednarova, and Michaela Vorlickova18 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDE NUCLEIC ACIDS AND THEIR ANALOGUES 587Roberto Corradini, Tullia Tedeschi, Stefano Sforza, and Rosangela Marchelli19 CIRCULAR DICHROISM OF PROTEIN–NUCLEIC ACID INTERACTIONS 615Donald M. Gray20 DRUG AND NATURAL PRODUCT BINDING TO NUCLEIC ACIDS ANALYZED BY ELECTRONIC CIRCULAR DICHROISM 635George A. Ellestad21 PROBING HSA AND AGP DRUG-BINDING SITES BY ELECTRONIC CIRCULAR DICHROISM 665Miklos Simonyi22 CONFORMATIONAL STUDIES OF BIOPOLYMERS, PEPTIDES, PROTEINS, AND NUCLEIC ACIDS. A ROLE FOR VIBRATIONAL CIRCULAR DICHROISM 707Timothy A. Keiderling and Ahmed Lakhani23 STRUCTURE AND BEHAVIOR OF BIOMOLECULES FROM RAMAN OPTICAL ACTIVITY 759Laurence D. Barron and Lutz Hecht24 OPTICAL ROTATION, ELECTRONIC CIRCULAR DICHROISM, AND VIBRATIONAL CIRCULAR DICHROISM OF CARBOHYDRATES AND GLYCOCONJUGATES 795Tohru Taniguchi and Kenji Monde25 ELECTRONIC CIRCULAR DICHROISM IN DRUG DISCOVERY 819Carlo Bertucci and Marco PistolozziINDEX 843