EDITED BY Howard L. Weiner, MD, Harvard Medical School, and Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, Boston, MA, USA James M. Stankiewicz, MD, Harvard Medical School, and Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, Boston, MA, USA

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• List of Contributors, vii Preface, ixPart I Pathology and Diagnosis, 11 Disease Pathogenesis, 3Roopali Gandhi and Howard L. Weiner2 Biomarkers, 26Manuel Comabella and Samia J. Khoury3 Epidemiology and Genetics, 56Philip L. De Jager4 Diagnosis, 77James M. Stankiewicz, Varun Chaubal, and Guy J. Buckle5 Pediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis, 101Tanuja Chitnis6 Magnetic Resonance Imaging in Multiple Sclerosis, 136Mohit Neema, Antonia Ceccarelli, Jonathan S. Jackson, and Rohit Bakshi7 Predicting Clinical Course, 163Brian Healy and Maria LiguoriPart II Management, 1818 Medication Treatment in Multiple Sclerosis, 183James M. Stankiewicz and Samia J. Khoury9 Symptom Management, 213Lynn Stazzone and Brandon Brown10 Cognitive Dysfunction in Multiple Sclerosis, 239Bonnie I. Glanz and Maria K. Houtchens11 Depression and Other Psychosocial Issues in Multiple Sclerosis, 263David J. Rintell12 Future Therapeutic Approaches, 283Howard L. Weiner and Laura EdwardsIndex, 301

EDITED BY Howard L. Weiner, MD, Harvard Medical School, and Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, Boston, MA, USA James M. Stankiewicz, MD, Harvard Medical School, and Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, Boston, MA, USA

Select Guide Rating

• List of Contributors, vii Preface, ixPart I Pathology and Diagnosis, 11 Disease Pathogenesis, 3Roopali Gandhi and Howard L. Weiner2 Biomarkers, 26Manuel Comabella and Samia J. Khoury3 Epidemiology and Genetics, 56Philip L. De Jager4 Diagnosis, 77James M. Stankiewicz, Varun Chaubal, and Guy J. Buckle5 Pediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis, 101Tanuja Chitnis6 Magnetic Resonance Imaging in Multiple Sclerosis, 136Mohit Neema, Antonia Ceccarelli, Jonathan S. Jackson, and Rohit Bakshi7 Predicting Clinical Course, 163Brian Healy and Maria LiguoriPart II Management, 1818 Medication Treatment in Multiple Sclerosis, 183James M. Stankiewicz and Samia J. Khoury9 Symptom Management, 213Lynn Stazzone and Brandon Brown10 Cognitive Dysfunction in Multiple Sclerosis, 239Bonnie I. Glanz and Maria K. Houtchens11 Depression and Other Psychosocial Issues in Multiple Sclerosis, 263David J. Rintell12 Future Therapeutic Approaches, 283Howard L. Weiner and Laura EdwardsIndex, 301

EDITED BY Howard L. Weiner, MD, Harvard Medical School, and Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, Boston, MA, USA James M. Stankiewicz, MD, Harvard Medical School, and Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, Boston, MA, USA

Select Guide Rating

• List of Contributors, vii Preface, ixPart I Pathology and Diagnosis, 11 Disease Pathogenesis, 3Roopali Gandhi and Howard L. Weiner2 Biomarkers, 26Manuel Comabella and Samia J. Khoury3 Epidemiology and Genetics, 56Philip L. De Jager4 Diagnosis, 77James M. Stankiewicz, Varun Chaubal, and Guy J. Buckle5 Pediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis, 101Tanuja Chitnis6 Magnetic Resonance Imaging in Multiple Sclerosis, 136Mohit Neema, Antonia Ceccarelli, Jonathan S. Jackson, and Rohit Bakshi7 Predicting Clinical Course, 163Brian Healy and Maria LiguoriPart II Management, 1818 Medication Treatment in Multiple Sclerosis, 183James M. Stankiewicz and Samia J. Khoury9 Symptom Management, 213Lynn Stazzone and Brandon Brown10 Cognitive Dysfunction in Multiple Sclerosis, 239Bonnie I. Glanz and Maria K. Houtchens11 Depression and Other Psychosocial Issues in Multiple Sclerosis, 263David J. Rintell12 Future Therapeutic Approaches, 283Howard L. Weiner and Laura EdwardsIndex, 301