Metabolomics by In Vivo NMR

Inbunden, Engelska, 2004

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Beskrivning

Metabolism By In Vivo NMR reviews and extends the experimental and theoretical reports concerning in vivo NMR, a pioneering approach that offers versatile new ways of studying metabolic pathways. Perfectly timed to coincide with recent findings that demonstrate the novelty and strength of this approach, the book covers recent applications in biochemistry, medicine, and psychology; in vivo NMR techniques; MCA; glucose metabolism focusing on glycogen; the value of muscle glycogen measurements in exercise; and much more. This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease statesProvides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disordersNovel and potentially controversialWill inspire future research directions.

Produktinformation

Utgivningsdatum:2004-12-17
Mått:195 x 251 x 17 mm
Vikt:595 g
Format:Inbunden
Språk:Engelska
Antal sidor:208
Förlag:John Wiley & Sons Inc
ISBN:9780470847190

Utforska kategorier

Biokemi inom Naturvetenskap och teknik

Mer om författaren

Editors: Robert G. Shulman and Douglas L. Rothman, Yale University School of Medicine, New Haven, Connecticut, USA

Innehållsförteckning

Contributors xiForeword xiiiSir George K. Radda, Medical Research Council, UKSection A: Background1 Introduction 1Robert G. Shulman2 In Vivo NMR Spectroscopy – Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations 7Robin de Graaf3 Metabolic Control Analysis for the NMR Spectroscopist 31David A. FellSection B: 13C and 31P NMR Studies of the Regulation of Glucose Metabolism4 MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes 45Gerald I. Shulman and Douglas L. Rothman5 Phosphorylation of Allosteric Enzymes can serve Homeostasis rather than Control Flux: the Example of Glycogen Synthase 59James R.A. Schafer, David A. Fell, Douglas Rothman and Robert G. Shulman6 Regulation of Glycogen Metabolism in Muscle during Exercise 73Thomas B. Price7 13C NMR Studies of Heart Glycogen Metabolism 87Maren R. Laughlin, Douglas L. Rothman and Robert G. Shulman8 Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction 103Thomas Jue9 Lactate, Glycogen and Fatigue 125Robert G. Shulman and Douglas L. Rothman10 Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty 137Jan den Hollander and Robert G. Shulman11 Trehalose Energetics in Yeast Spores 149Robert G. Shulman and Jan den Hollander12 Metabolic Networks in the Liver by 2H and 13C NMR 159A. Dean Sherry and Craig R. Malloy13 Summarized Reflections on Metabolism 175Robert G. Shulman and James R. A. SchaferIndex 185