Editors: Robert G. Shulman and Douglas L. Rothman, Yale University School of Medicine, New Haven, Connecticut, USA

• Contributors xiForeword xiiiSir George K. Radda, Medical Research Council, UKSection A: Background1 Introduction 1Robert G. Shulman2 In Vivo NMR Spectroscopy – Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations 7Robin de Graaf3 Metabolic Control Analysis for the NMR Spectroscopist 31David A. FellSection B: 13C and 31P NMR Studies of the Regulation of Glucose Metabolism4 MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes 45Gerald I. Shulman and Douglas L. Rothman5 Phosphorylation of Allosteric Enzymes can serve Homeostasis rather than Control Flux: the Example of Glycogen Synthase 59James R.A. Schafer, David A. Fell, Douglas Rothman and Robert G. Shulman6 Regulation of Glycogen Metabolism in Muscle during Exercise 73Thomas B. Price7 13C NMR Studies of Heart Glycogen Metabolism 87Maren R. Laughlin, Douglas L. Rothman and Robert G. Shulman8 Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction 103Thomas Jue9 Lactate, Glycogen and Fatigue 125Robert G. Shulman and Douglas L. Rothman10 Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty 137Jan den Hollander and Robert G. Shulman11 Trehalose Energetics in Yeast Spores 149Robert G. Shulman and Jan den Hollander12 Metabolic Networks in the Liver by 2H and 13C NMR 159A. Dean Sherry and Craig R. Malloy13 Summarized Reflections on Metabolism 175Robert G. Shulman and James R. A. SchaferIndex 185

Editors: Robert G. Shulman and Douglas L. Rothman, Yale University School of Medicine, New Haven, Connecticut, USA

• Contributors xiForeword xiiiSir George K. Radda, Medical Research Council, UKSection A: Background1 Introduction 1Robert G. Shulman2 In Vivo NMR Spectroscopy – Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations 7Robin de Graaf3 Metabolic Control Analysis for the NMR Spectroscopist 31David A. FellSection B: 13C and 31P NMR Studies of the Regulation of Glucose Metabolism4 MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes 45Gerald I. Shulman and Douglas L. Rothman5 Phosphorylation of Allosteric Enzymes can serve Homeostasis rather than Control Flux: the Example of Glycogen Synthase 59James R.A. Schafer, David A. Fell, Douglas Rothman and Robert G. Shulman6 Regulation of Glycogen Metabolism in Muscle during Exercise 73Thomas B. Price7 13C NMR Studies of Heart Glycogen Metabolism 87Maren R. Laughlin, Douglas L. Rothman and Robert G. Shulman8 Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction 103Thomas Jue9 Lactate, Glycogen and Fatigue 125Robert G. Shulman and Douglas L. Rothman10 Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty 137Jan den Hollander and Robert G. Shulman11 Trehalose Energetics in Yeast Spores 149Robert G. Shulman and Jan den Hollander12 Metabolic Networks in the Liver by 2H and 13C NMR 159A. Dean Sherry and Craig R. Malloy13 Summarized Reflections on Metabolism 175Robert G. Shulman and James R. A. SchaferIndex 185

Editors: Robert G. Shulman and Douglas L. Rothman, Yale University School of Medicine, New Haven, Connecticut, USA

• Contributors xiForeword xiiiSir George K. Radda, Medical Research Council, UKSection A: Background1 Introduction 1Robert G. Shulman2 In Vivo NMR Spectroscopy – Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations 7Robin de Graaf3 Metabolic Control Analysis for the NMR Spectroscopist 31David A. FellSection B: 13C and 31P NMR Studies of the Regulation of Glucose Metabolism4 MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes 45Gerald I. Shulman and Douglas L. Rothman5 Phosphorylation of Allosteric Enzymes can serve Homeostasis rather than Control Flux: the Example of Glycogen Synthase 59James R.A. Schafer, David A. Fell, Douglas Rothman and Robert G. Shulman6 Regulation of Glycogen Metabolism in Muscle during Exercise 73Thomas B. Price7 13C NMR Studies of Heart Glycogen Metabolism 87Maren R. Laughlin, Douglas L. Rothman and Robert G. Shulman8 Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction 103Thomas Jue9 Lactate, Glycogen and Fatigue 125Robert G. Shulman and Douglas L. Rothman10 Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty 137Jan den Hollander and Robert G. Shulman11 Trehalose Energetics in Yeast Spores 149Robert G. Shulman and Jan den Hollander12 Metabolic Networks in the Liver by 2H and 13C NMR 159A. Dean Sherry and Craig R. Malloy13 Summarized Reflections on Metabolism 175Robert G. Shulman and James R. A. SchaferIndex 185