ERIC J. TOONE is Professor of Chemistry and Professor of Biochemistry at Duke University in Durham, North Carolina.

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• Contributors viiPreface ixAbstracts xiMolecular Paleoscience: Systems Biology from the Past 1Steven A. Benner, Slim O. Sassi, and Eric A. GaucherA Structure-Centric View of Protein Evolution, Design, and Adaptation 133Eric J. Deeds and Eugene I. ShakhnovichMechanisms of Protein Evolution and Their Application to Protein Engineering 193Margaret E. Glasner, John A. Gerlt, and Patricia C. BabbittNovel Enzymes Through Design and Evolution 241Kenneth J. Woycechowsky, Katherina Vamvaca, and Donald HilvertAuthor Index 295Subject Index 301

ERIC J. TOONE is Professor of Chemistry and Professor of Biochemistry at Duke University in Durham, North Carolina.

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• Contributors viiPreface ixAbstracts xiMolecular Paleoscience: Systems Biology from the Past 1Steven A. Benner, Slim O. Sassi, and Eric A. GaucherA Structure-Centric View of Protein Evolution, Design, and Adaptation 133Eric J. Deeds and Eugene I. ShakhnovichMechanisms of Protein Evolution and Their Application to Protein Engineering 193Margaret E. Glasner, John A. Gerlt, and Patricia C. BabbittNovel Enzymes Through Design and Evolution 241Kenneth J. Woycechowsky, Katherina Vamvaca, and Donald HilvertAuthor Index 295Subject Index 301

ERIC J. TOONE is Professor of Chemistry and Professor of Biochemistry at Duke University in Durham, North Carolina.

Select Guide Rating

• Contributors viiPreface ixAbstracts xiMolecular Paleoscience: Systems Biology from the Past 1Steven A. Benner, Slim O. Sassi, and Eric A. GaucherA Structure-Centric View of Protein Evolution, Design, and Adaptation 133Eric J. Deeds and Eugene I. ShakhnovichMechanisms of Protein Evolution and Their Application to Protein Engineering 193Margaret E. Glasner, John A. Gerlt, and Patricia C. BabbittNovel Enzymes Through Design and Evolution 241Kenneth J. Woycechowsky, Katherina Vamvaca, and Donald HilvertAuthor Index 295Subject Index 301