Chris J. van Boxtel is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.Budiono Santoso is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.I. Ralph Edwards is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.

"...I can recommend this book to those who work in the area of herbal medicine and nutritional supplements..." (Focus on Alternative and Complementary Therapies, June 2002) "...outlines the scientific basis and practice of drug therapy." (SciTech Book News, Vol. 26, No. 2, June 2002)"...order this book at once and read it from cover to cover..." (Pharmaceutical Physician, September 2002)"…I thoroughly enjoyed reviewing this book and learnt a great deal in the process…" (British Journal of Clinical Pharmacology, August 2002)

• List of Contributors Foreword Preface Section I General Principles Part A Medicinals in Society The Role of Therapeutic Agents in Modern Medicine (Ronald A Mann and Jerry Avorn) Therapeutics as a Science (Marcus N. Reidenberg) Pharmacoepidemiology and Drug Evaluation (Supornchai Kongpatanakul and Brian L Strom) Pharmacoeconomics (Kevin A Schulman et al) National Drug Policy and the Role of Clinical Pharmacology (Marc Blockman and Peter I Folb) Drug Regulation: Organization and Control (Budiono Santoso) Sources of Drug Information (Joe Talmud) Drug Development (Peter van Brummelen) Part B General Clinical Pharmacology Clinical Pharmacokinetics (Anthony J Smith and Sri Suryawati) Clinical Pharmacodynamics (Gunnar Alvan et al) Drug Therapy in Pediatric Patients (Gregory L Kearns et al) Drug Therapy in Older Persons (Barry J Cusack) Adverse Drug Reactions (I Ralph Edwards) Drug-Drug Interactions (Anne Lee and Ivan H Stockley) Drug Misuse-Harmful Use, Abuse and Dependence (I Ralph Edwards) Clinical Pharmacology of Poisoning (Kenneth Y Hartigan-Go) Section II Pharmacotherapeutic Products Neurohumoral Transmission (M Pfaffendorf) Drugs Acting on the Central Nervous System (Chris J van Boxtel and A Buitenhuis) Cardiovascular and Renal Drugs (P A van Zwieten) Antimicrobial Agents (Chris J van Boxtel) Drugs Affecting Gastrointestinal Function (Chris J van Boxtel) Hemopoietic Drugs and Drugs that Affect Coagulation (Chris J van Boxtel) Hormones and Hormone Antagonists (Chris J van Boxtel) Autacoids (M Pfaffendorf) Analgesics, Antirheumatics and Drugs for the Treatment of Gout (Chris J van Boxtel) Antineoplastic Agents (Chris J van Boxtel) Drugs used for Immunomodulation (Chris J van Boxtel) Vitamins (Chris J van Boxtel) Agents used in Dermatology and Miscellaneous Agents (Chris J van Boxtel and A Buitenhuis) Section II Treatment of Health Problems Symptomatic Treatment (Iwan Darmansjah and Inger Hagqvist) Emergency Medicine (Robin E Ferner and Molly Thomas) Treatment and Prophylaxis of Infectious Diseases (Michiel A van Agtmael et al) Care and Support for People with HIV Infection (Joseph H Perrië ns) Cardiovascular and Renal Diseases (Y K Seedat et al) Gastrointestinal and Hepatobiliary Disorders (m J S Langman) Pharmacotherapy of Chronic Obstructive Pulmonary Disease (Dieter Ukena) Disorders of Connective Tissue, Bone and Joints (John Darmawan) Treatment of Psychiatric Disorders (Nicholas Moore and Bernard Bé gaud) Neurological Disease (Hervé Allain and Sté phane Schü ck) Drug Use for Malignancies (Maja J A de Jonge and Jaap Verweij) Haematological Disorders (Peter Jacobs et al) Endocrine Diseases (Robert Djokomoeljanto and Julian R E Davis) Index

Chris J. van Boxtel is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.Budiono Santoso is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.I. Ralph Edwards is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.

"...I can recommend this book to those who work in the area of herbal medicine and nutritional supplements..." (Focus on Alternative and Complementary Therapies, June 2002) "...outlines the scientific basis and practice of drug therapy." (SciTech Book News, Vol. 26, No. 2, June 2002)"...order this book at once and read it from cover to cover..." (Pharmaceutical Physician, September 2002)"…I thoroughly enjoyed reviewing this book and learnt a great deal in the process…" (British Journal of Clinical Pharmacology, August 2002)

• List of Contributors Foreword Preface Section I General Principles Part A Medicinals in Society The Role of Therapeutic Agents in Modern Medicine (Ronald A Mann and Jerry Avorn) Therapeutics as a Science (Marcus N. Reidenberg) Pharmacoepidemiology and Drug Evaluation (Supornchai Kongpatanakul and Brian L Strom) Pharmacoeconomics (Kevin A Schulman et al) National Drug Policy and the Role of Clinical Pharmacology (Marc Blockman and Peter I Folb) Drug Regulation: Organization and Control (Budiono Santoso) Sources of Drug Information (Joe Talmud) Drug Development (Peter van Brummelen) Part B General Clinical Pharmacology Clinical Pharmacokinetics (Anthony J Smith and Sri Suryawati) Clinical Pharmacodynamics (Gunnar Alvan et al) Drug Therapy in Pediatric Patients (Gregory L Kearns et al) Drug Therapy in Older Persons (Barry J Cusack) Adverse Drug Reactions (I Ralph Edwards) Drug-Drug Interactions (Anne Lee and Ivan H Stockley) Drug Misuse-Harmful Use, Abuse and Dependence (I Ralph Edwards) Clinical Pharmacology of Poisoning (Kenneth Y Hartigan-Go) Section II Pharmacotherapeutic Products Neurohumoral Transmission (M Pfaffendorf) Drugs Acting on the Central Nervous System (Chris J van Boxtel and A Buitenhuis) Cardiovascular and Renal Drugs (P A van Zwieten) Antimicrobial Agents (Chris J van Boxtel) Drugs Affecting Gastrointestinal Function (Chris J van Boxtel) Hemopoietic Drugs and Drugs that Affect Coagulation (Chris J van Boxtel) Hormones and Hormone Antagonists (Chris J van Boxtel) Autacoids (M Pfaffendorf) Analgesics, Antirheumatics and Drugs for the Treatment of Gout (Chris J van Boxtel) Antineoplastic Agents (Chris J van Boxtel) Drugs used for Immunomodulation (Chris J van Boxtel) Vitamins (Chris J van Boxtel) Agents used in Dermatology and Miscellaneous Agents (Chris J van Boxtel and A Buitenhuis) Section II Treatment of Health Problems Symptomatic Treatment (Iwan Darmansjah and Inger Hagqvist) Emergency Medicine (Robin E Ferner and Molly Thomas) Treatment and Prophylaxis of Infectious Diseases (Michiel A van Agtmael et al) Care and Support for People with HIV Infection (Joseph H Perrië ns) Cardiovascular and Renal Diseases (Y K Seedat et al) Gastrointestinal and Hepatobiliary Disorders (m J S Langman) Pharmacotherapy of Chronic Obstructive Pulmonary Disease (Dieter Ukena) Disorders of Connective Tissue, Bone and Joints (John Darmawan) Treatment of Psychiatric Disorders (Nicholas Moore and Bernard Bé gaud) Neurological Disease (Hervé Allain and Sté phane Schü ck) Drug Use for Malignancies (Maja J A de Jonge and Jaap Verweij) Haematological Disorders (Peter Jacobs et al) Endocrine Diseases (Robert Djokomoeljanto and Julian R E Davis) Index

Chris J. van Boxtel is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.Budiono Santoso is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.I. Ralph Edwards is the editor of Drug Benefits and Risks: International Textbook of Clinical Pharmacology, published by Wiley.

"...I can recommend this book to those who work in the area of herbal medicine and nutritional supplements..." (Focus on Alternative and Complementary Therapies, June 2002) "...outlines the scientific basis and practice of drug therapy." (SciTech Book News, Vol. 26, No. 2, June 2002)"...order this book at once and read it from cover to cover..." (Pharmaceutical Physician, September 2002)"…I thoroughly enjoyed reviewing this book and learnt a great deal in the process…" (British Journal of Clinical Pharmacology, August 2002)

• List of Contributors Foreword Preface Section I General Principles Part A Medicinals in Society The Role of Therapeutic Agents in Modern Medicine (Ronald A Mann and Jerry Avorn) Therapeutics as a Science (Marcus N. Reidenberg) Pharmacoepidemiology and Drug Evaluation (Supornchai Kongpatanakul and Brian L Strom) Pharmacoeconomics (Kevin A Schulman et al) National Drug Policy and the Role of Clinical Pharmacology (Marc Blockman and Peter I Folb) Drug Regulation: Organization and Control (Budiono Santoso) Sources of Drug Information (Joe Talmud) Drug Development (Peter van Brummelen) Part B General Clinical Pharmacology Clinical Pharmacokinetics (Anthony J Smith and Sri Suryawati) Clinical Pharmacodynamics (Gunnar Alvan et al) Drug Therapy in Pediatric Patients (Gregory L Kearns et al) Drug Therapy in Older Persons (Barry J Cusack) Adverse Drug Reactions (I Ralph Edwards) Drug-Drug Interactions (Anne Lee and Ivan H Stockley) Drug Misuse-Harmful Use, Abuse and Dependence (I Ralph Edwards) Clinical Pharmacology of Poisoning (Kenneth Y Hartigan-Go) Section II Pharmacotherapeutic Products Neurohumoral Transmission (M Pfaffendorf) Drugs Acting on the Central Nervous System (Chris J van Boxtel and A Buitenhuis) Cardiovascular and Renal Drugs (P A van Zwieten) Antimicrobial Agents (Chris J van Boxtel) Drugs Affecting Gastrointestinal Function (Chris J van Boxtel) Hemopoietic Drugs and Drugs that Affect Coagulation (Chris J van Boxtel) Hormones and Hormone Antagonists (Chris J van Boxtel) Autacoids (M Pfaffendorf) Analgesics, Antirheumatics and Drugs for the Treatment of Gout (Chris J van Boxtel) Antineoplastic Agents (Chris J van Boxtel) Drugs used for Immunomodulation (Chris J van Boxtel) Vitamins (Chris J van Boxtel) Agents used in Dermatology and Miscellaneous Agents (Chris J van Boxtel and A Buitenhuis) Section II Treatment of Health Problems Symptomatic Treatment (Iwan Darmansjah and Inger Hagqvist) Emergency Medicine (Robin E Ferner and Molly Thomas) Treatment and Prophylaxis of Infectious Diseases (Michiel A van Agtmael et al) Care and Support for People with HIV Infection (Joseph H Perrië ns) Cardiovascular and Renal Diseases (Y K Seedat et al) Gastrointestinal and Hepatobiliary Disorders (m J S Langman) Pharmacotherapy of Chronic Obstructive Pulmonary Disease (Dieter Ukena) Disorders of Connective Tissue, Bone and Joints (John Darmawan) Treatment of Psychiatric Disorders (Nicholas Moore and Bernard Bé gaud) Neurological Disease (Hervé Allain and Sté phane Schü ck) Drug Use for Malignancies (Maja J A de Jonge and Jaap Verweij) Haematological Disorders (Peter Jacobs et al) Endocrine Diseases (Robert Djokomoeljanto and Julian R E Davis) Index