'The excellence of this book is the section on special patient populations. They are all extremely well covered … This book will be valuable for researchers, academics who are interested in the scholarly reviews and algorithms of treatments, clinicians with special interest in affective disorders, and any clinician who would like a valuable resource book in their library.' International Journal of Geriatric Psychiatry

• List of contributors; Preface; Part I. The Clinical Problem: 1. The characterization and definition of treatment-resistant mood disorders Daniel Souery, Olivier Lipp, Isabelle Massat and Julien Mendlewicz; 2. Overview of treatment-resistant depression and its management John P. O'Reardon and Jay D. Amsterdam; Part II. Biological Basis: 3. Psychoneuroendocrine aspects of treatment-resistant mood disorders Owen M. Wolkowitz and Victor I. Reus; 4. Estrogen and depressive illness in women Barbara B. Sherwin; 5. Sleep abnormalities in treatment-resistant mood disorders Martin P. Szuba, Antonio T. Fernando and Geralyn Groh-Szuba; 6. Structural and functional brain imaging in treatment-resistant depression Terence A. Ketter, Christopher J. Bench, Mark S. George, Tim A. Kimbrell and Robert M. Post; 7. Immunologic factors in treatment-resistant depression Anna Sluzewska, Janusz Rybakowski, Mady Hornig and Jay D. Amsterdam; Part III. Treatment Approaches: 8. Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in treatment-resistant depression William Boyer and Richard Bunt; 9. Conventional and second generation monoamine oxidase inhibitors in treatment-resistant depression David Bakish and Cynthia L. Hooper; 10. Drug combination strategies Lawrence H. Price, Linda L. Carpenter and Steven A. Rasmussen; 11. Electroconvulsive therapy in medication-resistant depression Max Fink; 12. Thyroid augmentation Russell T. Joffe; 13. Cognitive therapy and psychosocial interventions in chronic and treatment-resistant mood disorders Jan Scott and Robert J. DeRubeis; Part IV. Special Patient Populations: 14. Chronic and refractory mood disorders in childhood and adolescence Adelita Segovia, Kelly N. Botteron and Barbara Geller; 15. Treatment-resistant depression in the elderly Paul A. Newhouse and Jaskaran Singh; 16. Management of treatment-resistant depression during pregnancy and the postpartum period Zachary N. Stowe, Pamela McCreary, Amy Hostetter, Claudia Baugh and Alexis Llewellyn; 17. Preliminary algorithms for treatment-resistant bipolar depression Robert M. Post, Mark A. Frye, Kirk D. Denicoff, Andrew M. Speer, Susan R. B. Weiss and Gabriele S. Leverich; 18. Medical disorders and treatment-resistant depression John P. O'Reardon and Jay D. Amsterdam; 19. Psychiatric comorbidity in treatment-resistant depression Jonathan E. Alpert and Isabelle T. Lagomasino; 20. Suicide in treatment-refractory depression Jan Fawcett and Stanley G. Harris Sr; Part V. Economic and Ethical Issues: 21. The economic impact of treatment non-response in major depressive disorders Jeffrey S. McCombs, Glen L. Stimmel, Rita L. Hui and T. Jeffrey White; 22. Ethical issues in research and treatment of patients with mood disorders Paul Root Wolpe and Arthur Caplan; Index.