Professor André F. Carvalho, MD, PhD, Associate Professor of Psychiatry, Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE Brazil.; Roger S. McIntyre is currently a Professor of Psychiatry and Pharmacology at the University of Toronto and Head of the Mood Disorders Psychopharmacology Unit at the University Health Network, Toronto, Canada. He was named by Thomson Reuters in 2014 as one of "The World's Most Influential Scientific Minds" for publishing the largest number of articles that rank among those most frequently cited by researchers globally during the previous decade. Dr. McIntyre is involved in multiple research endeavours which primarily aim to characterize the association between mood disorders, notably cognitive function and medical comorbidity. This body of work has provided a platform for identifying novel molecular targets to treat and prevent mood disorders and accompanying cognitive impairment.

Although small, this book provides a wealth of information about an extremely important area that is frequently misunderstood and undertreated. It is a useful read for all psychiatrists, but is a must read for all psychiatric residents.

• 1. Treatment-resistant major depressive disorder: Current Definitions, Epidemiology and Assessment ; 2. Treatment-resistant bipolar disorder: current definitions, epidemiology and assessment ; 3. Determinants of Treatment Resistance: Health Systems and Public Policy Implications ; 4. The influence of psychiatric and medical comorbidities in treatment resistance for mood disorders ; 5. Predictors of treatment response in major depressive disorder ; 6. Predictors of Treatment Response in Bipolar Disorder: Lessons from Longitudinal Studies ; 7. Evidence-based Pharmacological Approaches for Treatment-Resistant Major Depressive Disorder ; 8. Evidence-based pharmacological approaches for treatment-resistant bipolar disorder ; 9. Psychosocial management of treatment-resistant mood disorders: current evidence ; 10. Electroconvulsive therapy for treatment-resistant mood disorders ; 11. Novel non-invasive brain stimulation approaches for treatment-resistant mood disorders ; 12. Vagus Nerve Stimulation and Deep Brain Stimulation: Implantable Device-Related Neurostimulation for Treatment-Resistant Mood Disorders ; 13. Novel Therapeutic Targets for Major Depressive Disorder ; 14. Novel therapeutic targets for bipolar disorder

Professor André F. Carvalho, MD, PhD, Associate Professor of Psychiatry, Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE Brazil.; Roger S. McIntyre is currently a Professor of Psychiatry and Pharmacology at the University of Toronto and Head of the Mood Disorders Psychopharmacology Unit at the University Health Network, Toronto, Canada. He was named by Thomson Reuters in 2014 as one of "The World's Most Influential Scientific Minds" for publishing the largest number of articles that rank among those most frequently cited by researchers globally during the previous decade. Dr. McIntyre is involved in multiple research endeavours which primarily aim to characterize the association between mood disorders, notably cognitive function and medical comorbidity. This body of work has provided a platform for identifying novel molecular targets to treat and prevent mood disorders and accompanying cognitive impairment.

Although small, this book provides a wealth of information about an extremely important area that is frequently misunderstood and undertreated. It is a useful read for all psychiatrists, but is a must read for all psychiatric residents.

• 1. Treatment-resistant major depressive disorder: Current Definitions, Epidemiology and Assessment ; 2. Treatment-resistant bipolar disorder: current definitions, epidemiology and assessment ; 3. Determinants of Treatment Resistance: Health Systems and Public Policy Implications ; 4. The influence of psychiatric and medical comorbidities in treatment resistance for mood disorders ; 5. Predictors of treatment response in major depressive disorder ; 6. Predictors of Treatment Response in Bipolar Disorder: Lessons from Longitudinal Studies ; 7. Evidence-based Pharmacological Approaches for Treatment-Resistant Major Depressive Disorder ; 8. Evidence-based pharmacological approaches for treatment-resistant bipolar disorder ; 9. Psychosocial management of treatment-resistant mood disorders: current evidence ; 10. Electroconvulsive therapy for treatment-resistant mood disorders ; 11. Novel non-invasive brain stimulation approaches for treatment-resistant mood disorders ; 12. Vagus Nerve Stimulation and Deep Brain Stimulation: Implantable Device-Related Neurostimulation for Treatment-Resistant Mood Disorders ; 13. Novel Therapeutic Targets for Major Depressive Disorder ; 14. Novel therapeutic targets for bipolar disorder

Professor André F. Carvalho, MD, PhD, Associate Professor of Psychiatry, Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE Brazil.; Roger S. McIntyre is currently a Professor of Psychiatry and Pharmacology at the University of Toronto and Head of the Mood Disorders Psychopharmacology Unit at the University Health Network, Toronto, Canada. He was named by Thomson Reuters in 2014 as one of "The World's Most Influential Scientific Minds" for publishing the largest number of articles that rank among those most frequently cited by researchers globally during the previous decade. Dr. McIntyre is involved in multiple research endeavours which primarily aim to characterize the association between mood disorders, notably cognitive function and medical comorbidity. This body of work has provided a platform for identifying novel molecular targets to treat and prevent mood disorders and accompanying cognitive impairment.

Although small, this book provides a wealth of information about an extremely important area that is frequently misunderstood and undertreated. It is a useful read for all psychiatrists, but is a must read for all psychiatric residents.

• 1. Treatment-resistant major depressive disorder: Current Definitions, Epidemiology and Assessment ; 2. Treatment-resistant bipolar disorder: current definitions, epidemiology and assessment ; 3. Determinants of Treatment Resistance: Health Systems and Public Policy Implications ; 4. The influence of psychiatric and medical comorbidities in treatment resistance for mood disorders ; 5. Predictors of treatment response in major depressive disorder ; 6. Predictors of Treatment Response in Bipolar Disorder: Lessons from Longitudinal Studies ; 7. Evidence-based Pharmacological Approaches for Treatment-Resistant Major Depressive Disorder ; 8. Evidence-based pharmacological approaches for treatment-resistant bipolar disorder ; 9. Psychosocial management of treatment-resistant mood disorders: current evidence ; 10. Electroconvulsive therapy for treatment-resistant mood disorders ; 11. Novel non-invasive brain stimulation approaches for treatment-resistant mood disorders ; 12. Vagus Nerve Stimulation and Deep Brain Stimulation: Implantable Device-Related Neurostimulation for Treatment-Resistant Mood Disorders ; 13. Novel Therapeutic Targets for Major Depressive Disorder ; 14. Novel therapeutic targets for bipolar disorder