' … anyone whose clinical or research work involves pre-eclampsia should find this book a valuable resource,.' The Obstetrician and Gynaecologist

• List of contributors; Preface; Part I. Basic Science: 1. Trophoblast invasion in pre-eclampsia and other pregnancy disorders Robert Pijnenborg, Lisbeth Vercruysse, Myriam Hanssens and F. André Van Assche; 2. Development of the utero-placental circulation: purported mechanisms for cytotrophoblast invasion in normal pregnancy and pre-eclampsia Fiona Lyall; 3. In Vitro models for studying pre-eclampsia John Aplin and Ian P. Crocker; 4. Endothelial factors Muna Noori, Mina Savvidou and David Williams; 5. The renin-angiotensin system in pre-eclampsia Fiona Broughton Pipkin; 6. Immunological factors and placentation: implications for pre-eclampsia Ashley Moffett and Susan Hiby; 7. Immunological factors and placentation: implications for pre-eclampsia C. W. G. Redman and I. L. Sargent; 8. The role of oxidative stress in pre-eclampsia M. T. M. Raijmaker and L. Poston; 9. Placental hypoxia, hyperoxia and ischaemia–reperfusion injury in pre-eclampsia Graham Burton, Tai-Ho Hung, and Eric Jauniaux; 10. Tenney–Parker changes and apoptotic versus necrotic shedding of trophoblast in normal pregnancy and pre-eclampsia Peter Kaufmann and Berthold Huppertz; 11. Dyslipidemia and pre-eclampsia Carl A. Hubel; 12. Pre-eclampsia a two-stage disorder: what is the linkage? Are there directed fetal/placental signals? Jim Roberts 13. High altitude and pre-eclampsia Stacy Zamudio; 14. The use of mouse models to explore fetal–maternal interactions underlying pre-eclampsia James C. Cross; 15. Prediction of pre-eclampsia Leslie Myatt and Lavenia B. Carpenter; 16. Long-term implications of pre-eclampsia for maternal health Gordon C. S. Smith; Part II. Clinical Practice: 17. Classification and diagnosis of pre-eclampsia Robyn A. North; 18. Measuring blood pressure in pregnancy and pre-eclampsia Andrew H. Shennan and Annemarie De Greeff; 19. Immune maladaptation in the etiology of pre-eclampsia: an updated epidemiological perspective Gus Dekker and Pierre Yves Robillard; 20. Genetics of pre-eclampsia and counselling the patient who has developed pre-eclampsia Kenneth Ward; 21. Thrombophilias and pre-eclampsia Isobel D. Walker; 22. Medical illness and the risk of pre-eclampsia Catherine Nelson-Piercy; 23. The kidney and pre-eclampsia M. C. Smith and J. M. Davison; 24. Management of mild pre-eclampsia Tracey Glanville and James J. Walker; 25. Management of severe pre-eclampsia Kristin H. Coppage and Baha M. Sibai; 26. The differential diagnosis of pre-eclampsia and eclampsia Michael Varner; 27. Complications of pre-eclampsia Gary A. Dildy III and Michael A. Belfort; 28. Central nervous system findings in pre-eclampsia and eclampsia Diane Twickler and F. Gary Cunningham; 29. Pathogenesis and treatment of eclampsia Joong Shin Park, Michael A. Belfort and Errol R. Norwitz; 30. Anaesthesia for the pre-eclamptic patient Jose M. Rivers and Maya S. Suresh; 31. Critical care management of severe pre-eclampsia John Anthony; 32. The role of maternal and fetal Doppler in pre-eclampsia J. Hornbuckle and S. Robson; 33. Pregnancy-induced hypertension - the effects on the newborn Jonathan Coutts; 34. Medico-legal implications of the diagnosis of pre-eclampsia Jeffrey P. Phelan; Subject Index.

' … anyone whose clinical or research work involves pre-eclampsia should find this book a valuable resource,.' The Obstetrician and Gynaecologist

• List of contributors; Preface; Part I. Basic Science: 1. Trophoblast invasion in pre-eclampsia and other pregnancy disorders Robert Pijnenborg, Lisbeth Vercruysse, Myriam Hanssens and F. André Van Assche; 2. Development of the utero-placental circulation: purported mechanisms for cytotrophoblast invasion in normal pregnancy and pre-eclampsia Fiona Lyall; 3. In Vitro models for studying pre-eclampsia John Aplin and Ian P. Crocker; 4. Endothelial factors Muna Noori, Mina Savvidou and David Williams; 5. The renin-angiotensin system in pre-eclampsia Fiona Broughton Pipkin; 6. Immunological factors and placentation: implications for pre-eclampsia Ashley Moffett and Susan Hiby; 7. Immunological factors and placentation: implications for pre-eclampsia C. W. G. Redman and I. L. Sargent; 8. The role of oxidative stress in pre-eclampsia M. T. M. Raijmaker and L. Poston; 9. Placental hypoxia, hyperoxia and ischaemia–reperfusion injury in pre-eclampsia Graham Burton, Tai-Ho Hung, and Eric Jauniaux; 10. Tenney–Parker changes and apoptotic versus necrotic shedding of trophoblast in normal pregnancy and pre-eclampsia Peter Kaufmann and Berthold Huppertz; 11. Dyslipidemia and pre-eclampsia Carl A. Hubel; 12. Pre-eclampsia a two-stage disorder: what is the linkage? Are there directed fetal/placental signals? Jim Roberts 13. High altitude and pre-eclampsia Stacy Zamudio; 14. The use of mouse models to explore fetal–maternal interactions underlying pre-eclampsia James C. Cross; 15. Prediction of pre-eclampsia Leslie Myatt and Lavenia B. Carpenter; 16. Long-term implications of pre-eclampsia for maternal health Gordon C. S. Smith; Part II. Clinical Practice: 17. Classification and diagnosis of pre-eclampsia Robyn A. North; 18. Measuring blood pressure in pregnancy and pre-eclampsia Andrew H. Shennan and Annemarie De Greeff; 19. Immune maladaptation in the etiology of pre-eclampsia: an updated epidemiological perspective Gus Dekker and Pierre Yves Robillard; 20. Genetics of pre-eclampsia and counselling the patient who has developed pre-eclampsia Kenneth Ward; 21. Thrombophilias and pre-eclampsia Isobel D. Walker; 22. Medical illness and the risk of pre-eclampsia Catherine Nelson-Piercy; 23. The kidney and pre-eclampsia M. C. Smith and J. M. Davison; 24. Management of mild pre-eclampsia Tracey Glanville and James J. Walker; 25. Management of severe pre-eclampsia Kristin H. Coppage and Baha M. Sibai; 26. The differential diagnosis of pre-eclampsia and eclampsia Michael Varner; 27. Complications of pre-eclampsia Gary A. Dildy III and Michael A. Belfort; 28. Central nervous system findings in pre-eclampsia and eclampsia Diane Twickler and F. Gary Cunningham; 29. Pathogenesis and treatment of eclampsia Joong Shin Park, Michael A. Belfort and Errol R. Norwitz; 30. Anaesthesia for the pre-eclamptic patient Jose M. Rivers and Maya S. Suresh; 31. Critical care management of severe pre-eclampsia John Anthony; 32. The role of maternal and fetal Doppler in pre-eclampsia J. Hornbuckle and S. Robson; 33. Pregnancy-induced hypertension - the effects on the newborn Jonathan Coutts; 34. Medico-legal implications of the diagnosis of pre-eclampsia Jeffrey P. Phelan; Subject Index.

' … anyone whose clinical or research work involves pre-eclampsia should find this book a valuable resource,.' The Obstetrician and Gynaecologist

• List of contributors; Preface; Part I. Basic Science: 1. Trophoblast invasion in pre-eclampsia and other pregnancy disorders Robert Pijnenborg, Lisbeth Vercruysse, Myriam Hanssens and F. André Van Assche; 2. Development of the utero-placental circulation: purported mechanisms for cytotrophoblast invasion in normal pregnancy and pre-eclampsia Fiona Lyall; 3. In Vitro models for studying pre-eclampsia John Aplin and Ian P. Crocker; 4. Endothelial factors Muna Noori, Mina Savvidou and David Williams; 5. The renin-angiotensin system in pre-eclampsia Fiona Broughton Pipkin; 6. Immunological factors and placentation: implications for pre-eclampsia Ashley Moffett and Susan Hiby; 7. Immunological factors and placentation: implications for pre-eclampsia C. W. G. Redman and I. L. Sargent; 8. The role of oxidative stress in pre-eclampsia M. T. M. Raijmaker and L. Poston; 9. Placental hypoxia, hyperoxia and ischaemia–reperfusion injury in pre-eclampsia Graham Burton, Tai-Ho Hung, and Eric Jauniaux; 10. Tenney–Parker changes and apoptotic versus necrotic shedding of trophoblast in normal pregnancy and pre-eclampsia Peter Kaufmann and Berthold Huppertz; 11. Dyslipidemia and pre-eclampsia Carl A. Hubel; 12. Pre-eclampsia a two-stage disorder: what is the linkage? Are there directed fetal/placental signals? Jim Roberts 13. High altitude and pre-eclampsia Stacy Zamudio; 14. The use of mouse models to explore fetal–maternal interactions underlying pre-eclampsia James C. Cross; 15. Prediction of pre-eclampsia Leslie Myatt and Lavenia B. Carpenter; 16. Long-term implications of pre-eclampsia for maternal health Gordon C. S. Smith; Part II. Clinical Practice: 17. Classification and diagnosis of pre-eclampsia Robyn A. North; 18. Measuring blood pressure in pregnancy and pre-eclampsia Andrew H. Shennan and Annemarie De Greeff; 19. Immune maladaptation in the etiology of pre-eclampsia: an updated epidemiological perspective Gus Dekker and Pierre Yves Robillard; 20. Genetics of pre-eclampsia and counselling the patient who has developed pre-eclampsia Kenneth Ward; 21. Thrombophilias and pre-eclampsia Isobel D. Walker; 22. Medical illness and the risk of pre-eclampsia Catherine Nelson-Piercy; 23. The kidney and pre-eclampsia M. C. Smith and J. M. Davison; 24. Management of mild pre-eclampsia Tracey Glanville and James J. Walker; 25. Management of severe pre-eclampsia Kristin H. Coppage and Baha M. Sibai; 26. The differential diagnosis of pre-eclampsia and eclampsia Michael Varner; 27. Complications of pre-eclampsia Gary A. Dildy III and Michael A. Belfort; 28. Central nervous system findings in pre-eclampsia and eclampsia Diane Twickler and F. Gary Cunningham; 29. Pathogenesis and treatment of eclampsia Joong Shin Park, Michael A. Belfort and Errol R. Norwitz; 30. Anaesthesia for the pre-eclamptic patient Jose M. Rivers and Maya S. Suresh; 31. Critical care management of severe pre-eclampsia John Anthony; 32. The role of maternal and fetal Doppler in pre-eclampsia J. Hornbuckle and S. Robson; 33. Pregnancy-induced hypertension - the effects on the newborn Jonathan Coutts; 34. Medico-legal implications of the diagnosis of pre-eclampsia Jeffrey P. Phelan; Subject Index.