Monoclonal Antibodies

Häftad, Engelska, 1995

Del i serien Postgraduate Medical Science

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Beskrivning

Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject. Monoclonal antibodies provide highly specific reagents with which to identify, analyse, quantitate and manipulate molecules - both in solution and in solid phase, such as at a cell surface. The aim of this book is therefore to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications of these antibodies in many areas of clinical medicine, including histopathology, oncology, transplantation, infectious diseases, rheumatology, haematology and dermatology.

Produktinformation

Utgivningsdatum:1995-01-26
Mått:170 x 245 x 25 mm
Vikt:798 g
Format:Häftad
Språk:Engelska
Serie:Postgraduate Medical Science
Antal sidor:500
Förlag:Cambridge University Press
ISBN:9780521425032

Utforska kategorier

Onkologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin

Recensioner i media

'This book provides a timely overview of the production and application of mAbs … if everyone using mAbs in their research were to read this then the work of referees might be much reduced … a valuable resource to anyone working with, or contemplating working with, mAbs.' Alan Trudgett, Society for General Microbiology Quarterly

Innehållsförteckning

1. Introduction; 2. Production of monoclonal antibodies; 3. Antigen–antibody interactions: how affinity and kinetics affect assay design and selection procedures; 4. The production and characterisation of synthetic peptide-derived antibodies; 5. Human monoclonal antibodies; 6. Bispecific monoclonal antibodies; 7. The production of antibodies using phage display libraries; 8. Genetic manipulation of monoclonal antibodies; 9. Monoclonal antibodies in diagnostic immunoassays; 10A. Monoclonal antibodies in diagnostic pathology; 10B. In vivo targeting of monoclonal antibodies for immunoscintigraphy and therapy of human malignancies; 11A. Monoclonal antibodies in infectious disease: diagnosis; 11B. Monoclonal antibodies in the prophyllaxis and therapy of infectious disease; 12A. Monoclonal antibodies in transplantation: immunohistology; 12B. Monoclonal antibodies in transplantation: experimental studies on in vivo immunosuppression; 12C. Monoclonal antibodies in transplantation: prophyllaxis of graft-versus-host disease after bone marrow transplantation; 12D. Monoclonal antibodies in transplantation: use as therapeutic agents in clinical organ transplantation; 13. Monoclonal antibodies and the skin; 14. Monoclonal antibodies in endocrinology; 15. Monoclonal antibodies in rheumatology; 16. Technical appendix.