'I really enjoyed tying together the cell biology and the basis of the current treatments and potential therapeutic interventions. I found that I knew a lot more about bone cell physiology, bone turnover and cell signalling by the end of the section. … The book succeeds as an introductory text on metabolic bone disease and provides insight into the complexity of the subject without becoming overwhelming.' Gerontology

• Preface Janet E. Henderson and David Goltzman; Part I. Molecular and Cellular Environment of Bone: 1. Endochondral bone formation and development in the axial and appendicular skeletaon A. Robin Poole, Sheila Laverty and Fackson Mwale; 2. The role of osteoblasts Jane E. Aubin; 3. Osteoclasts: characteristics and regulation of formation and activity Johan Heersche and Morris F. Manolson; 4. Bone matrix proteins Marc D. McKee and Jaro Sodek; 5. Local regulators of bone turnover Lawrence J. Fraher and Patricia H. Watson; 6. The PTH/PTHrP system and calcium homeostasis Geoffrey N. Hendy; 7. Vitamin D metabolism Marielle Gascon-Barre; 8. Sodium-dependent phosphate transport in kidney, bone and intestine Harriet S. Tenenhouse; Part II. Determinants of Peak Bone Mass: 9. Molecular genetic analysis of growth factor signalling in bone Janet E. Henderson and David Goltzman; 10. Genetic determinants of osteoporosis Milan S. Patel, Laurence A. Rubin and David E. C. Cole; 11. Non-genetic determinants of peak bone mass Velimir Matkovic and John D. Landoll; 12. Bone mineral acquisition during childhood and adolescence: physical exercise as a preventative measure Heather A. McKay and Karim M. Khan; 13. Osteoporosis in children Frank Rauch and Francis H. Glorieux; Part III. Pathophysiology of the Aging Skeleton: 14. Consequences of alterations in bone remodeling Karen Prestwood and Lawrence G. Raisz; 15. The role of parathyroid hormone and hyperparathyroidism in osteoporosis Pierre D'Amour; 16. Senile osteoporosis Patrick M. Doran and Sundeep Khosla; Part IV. Clinical Aspects of Osteoporosis; 17. Epidemiology Jaques Brown; 18. Biochemical markers of bone turnover David Hanley; 19. Radiologic assessment of osteoporosis Jaqueline C. Hodge; 20. Bone mineral density measurements Paul D. Miller and Carol Zapalowski; 21. Hormone replacement therapy Jonathan D. Adachi and Alexandra Papaioannou; 22. Selective estrogen receptor modulators Felicia Cosman and Robert Lindsay; 23. Bisphosphonate therapy of osteoporosis Fred Singer and Payam Minoofar; 24. The action of fluoride on bone Marc D. Grynpas, D. Chachra and H. Limeback; 25. PTH peptides as anabolic agents in bone Anthony B. Hodsman; 26. Vitamin D and Vitamin D analogs as therapeutic agents Richard Kremer.

'I really enjoyed tying together the cell biology and the basis of the current treatments and potential therapeutic interventions. I found that I knew a lot more about bone cell physiology, bone turnover and cell signalling by the end of the section. … The book succeeds as an introductory text on metabolic bone disease and provides insight into the complexity of the subject without becoming overwhelming.' Gerontology

• Preface Janet E. Henderson and David Goltzman; Part I. Molecular and Cellular Environment of Bone: 1. Endochondral bone formation and development in the axial and appendicular skeletaon A. Robin Poole, Sheila Laverty and Fackson Mwale; 2. The role of osteoblasts Jane E. Aubin; 3. Osteoclasts: characteristics and regulation of formation and activity Johan Heersche and Morris F. Manolson; 4. Bone matrix proteins Marc D. McKee and Jaro Sodek; 5. Local regulators of bone turnover Lawrence J. Fraher and Patricia H. Watson; 6. The PTH/PTHrP system and calcium homeostasis Geoffrey N. Hendy; 7. Vitamin D metabolism Marielle Gascon-Barre; 8. Sodium-dependent phosphate transport in kidney, bone and intestine Harriet S. Tenenhouse; Part II. Determinants of Peak Bone Mass: 9. Molecular genetic analysis of growth factor signalling in bone Janet E. Henderson and David Goltzman; 10. Genetic determinants of osteoporosis Milan S. Patel, Laurence A. Rubin and David E. C. Cole; 11. Non-genetic determinants of peak bone mass Velimir Matkovic and John D. Landoll; 12. Bone mineral acquisition during childhood and adolescence: physical exercise as a preventative measure Heather A. McKay and Karim M. Khan; 13. Osteoporosis in children Frank Rauch and Francis H. Glorieux; Part III. Pathophysiology of the Aging Skeleton: 14. Consequences of alterations in bone remodeling Karen Prestwood and Lawrence G. Raisz; 15. The role of parathyroid hormone and hyperparathyroidism in osteoporosis Pierre D'Amour; 16. Senile osteoporosis Patrick M. Doran and Sundeep Khosla; Part IV. Clinical Aspects of Osteoporosis; 17. Epidemiology Jaques Brown; 18. Biochemical markers of bone turnover David Hanley; 19. Radiologic assessment of osteoporosis Jaqueline C. Hodge; 20. Bone mineral density measurements Paul D. Miller and Carol Zapalowski; 21. Hormone replacement therapy Jonathan D. Adachi and Alexandra Papaioannou; 22. Selective estrogen receptor modulators Felicia Cosman and Robert Lindsay; 23. Bisphosphonate therapy of osteoporosis Fred Singer and Payam Minoofar; 24. The action of fluoride on bone Marc D. Grynpas, D. Chachra and H. Limeback; 25. PTH peptides as anabolic agents in bone Anthony B. Hodsman; 26. Vitamin D and Vitamin D analogs as therapeutic agents Richard Kremer.

'I really enjoyed tying together the cell biology and the basis of the current treatments and potential therapeutic interventions. I found that I knew a lot more about bone cell physiology, bone turnover and cell signalling by the end of the section. … The book succeeds as an introductory text on metabolic bone disease and provides insight into the complexity of the subject without becoming overwhelming.' Gerontology

• Preface Janet E. Henderson and David Goltzman; Part I. Molecular and Cellular Environment of Bone: 1. Endochondral bone formation and development in the axial and appendicular skeletaon A. Robin Poole, Sheila Laverty and Fackson Mwale; 2. The role of osteoblasts Jane E. Aubin; 3. Osteoclasts: characteristics and regulation of formation and activity Johan Heersche and Morris F. Manolson; 4. Bone matrix proteins Marc D. McKee and Jaro Sodek; 5. Local regulators of bone turnover Lawrence J. Fraher and Patricia H. Watson; 6. The PTH/PTHrP system and calcium homeostasis Geoffrey N. Hendy; 7. Vitamin D metabolism Marielle Gascon-Barre; 8. Sodium-dependent phosphate transport in kidney, bone and intestine Harriet S. Tenenhouse; Part II. Determinants of Peak Bone Mass: 9. Molecular genetic analysis of growth factor signalling in bone Janet E. Henderson and David Goltzman; 10. Genetic determinants of osteoporosis Milan S. Patel, Laurence A. Rubin and David E. C. Cole; 11. Non-genetic determinants of peak bone mass Velimir Matkovic and John D. Landoll; 12. Bone mineral acquisition during childhood and adolescence: physical exercise as a preventative measure Heather A. McKay and Karim M. Khan; 13. Osteoporosis in children Frank Rauch and Francis H. Glorieux; Part III. Pathophysiology of the Aging Skeleton: 14. Consequences of alterations in bone remodeling Karen Prestwood and Lawrence G. Raisz; 15. The role of parathyroid hormone and hyperparathyroidism in osteoporosis Pierre D'Amour; 16. Senile osteoporosis Patrick M. Doran and Sundeep Khosla; Part IV. Clinical Aspects of Osteoporosis; 17. Epidemiology Jaques Brown; 18. Biochemical markers of bone turnover David Hanley; 19. Radiologic assessment of osteoporosis Jaqueline C. Hodge; 20. Bone mineral density measurements Paul D. Miller and Carol Zapalowski; 21. Hormone replacement therapy Jonathan D. Adachi and Alexandra Papaioannou; 22. Selective estrogen receptor modulators Felicia Cosman and Robert Lindsay; 23. Bisphosphonate therapy of osteoporosis Fred Singer and Payam Minoofar; 24. The action of fluoride on bone Marc D. Grynpas, D. Chachra and H. Limeback; 25. PTH peptides as anabolic agents in bone Anthony B. Hodsman; 26. Vitamin D and Vitamin D analogs as therapeutic agents Richard Kremer.