E. C. Rodriquez-Merchan is the editor of Inhibitors in Patients with Haemophilia, published by Wiley. Christine A. Lee is the editor of Inhibitors in Patients with Haemophilia, published by Wiley.

• Contributors. Preface.HAEMATOLOGY.1 Natural history of inhibitor in severe haemophilia A and B: incidence and prevalence.Jeanne Lusher (USA).2 Characterisation of inhibitors in congenital haemophilia.Kathelijne Peerlinck and Marc Jacquemin (Belgium).3 Incidence and prevalence of inhibitors and type of blood product in haemophilia A.Christine Lee and Thynn Thynn Yee (UK).4 Genetic basis of inhibitor development in severe haemophilia A and B.Edward Tuddenham (UK) and Johannes Oldenburg (Germany)..MANAGEMENT OF TREATMENT.5 Therapeutic products: human FVIII, porcine FVIII, prothrombin complex concentrates, activated prothrombin complex concentrates and recombinant FVIIa.Thierry Lambert (France).6 Methods: plasmapheresis and protein A immuno-adsorption.Eric Berntorp (Sweden).7 Venous access in children with inhibitors.Rolf Ljund (Sweden).IMMUNETOLERANCE.8 Immunetolerance: high dose regimen.Hans Brackmann and Thomas Wallny (Germany) (To be agreed).9 Immunetolerance: low dose regimen.Eveline Mauser-Bunschotten (Netherlands).10 Immunotolerance and choice of concentrates.Wolfgang Kreutz (Germany).11 Immunetolerance regimen: the North America registry (To be agreed).Donna DiMichele (USA)..MEDICAL MANAGEMENT OF BLEEDING EPISODES.12 Treatment of bleeding episodes in children.Joan Tusell (Spain).13 General medical management of bleeding episodes: haemarthroses, muscle haematoma, mucocutaneous bleed, haematuria.Manuel Quintana (Spain).14 Life- and limb-threatening bleeding episodes and intracranial bleeds.Sam Schulman (Sweden)..INHIBITORS IN HAEMOPHILIA B.15 Inhibitors in haemophilia B patients.India Warrier (USA).16 Inhibitors in mild/moderate haemophilia.Charles Hay (UK).17 Acquired inhibitors to FVIII.Craig Kessler (USA)..MUSCULOSKELETAL ISSUES.18 Pathogenesis of musculoskeletal complications of haemophilia.E C Rodriguez-Merchan (Spain).19 Orthopaedic management of haemarthroses.E C Rodriguez-Merchan (Spain).20 Synoviorthesis with Rifampicin.Horacio Caviglia (Argentina) and F Fernandez-Palazzi (Venezuela).21 Radiosynoviorthesis.Eric Berntorp (Sweden).22 Musculoskeletal MRI.Rachel Nuss and Jerome Wiedel (USA).23 Iliopsoas haematomas and limb compartment syndromes.Michael Heim (Israel).24 Pseudotumours.Marvin Gilbert (USA).25 Haemophilia patients with inhibitors: a rheumatologist´s point of view.John York (Australia).26 Rehabilitation.Felipe Querol and José Aznar (Spain).27 Physiotherapy.Karen Beeton (UK).28 Elective orthopaedic surgery in patients with high responding inhibitors-.Ivan Hvid, J Soballe and J Ingerslev (Denmark)..GENERAL SURGERY.29 General and emergency surgery in patients with high responding inhibitors.Owen Smith & Barry White (Ireland).30 Dental extractions.Uri Martinowitz (Israel)..PSYCHOSOCIAL ISSUES.31 Psychological issues.Pilar Arranz (Spain)..32 GENERAL STRATEGY FOR MANAGEMENT OF INHIBITOR PATIENTS.Inga Scharrer (Germany).Index

E. C. Rodriquez-Merchan is the editor of Inhibitors in Patients with Haemophilia, published by Wiley. Christine A. Lee is the editor of Inhibitors in Patients with Haemophilia, published by Wiley.

• Contributors. Preface.HAEMATOLOGY.1 Natural history of inhibitor in severe haemophilia A and B: incidence and prevalence.Jeanne Lusher (USA).2 Characterisation of inhibitors in congenital haemophilia.Kathelijne Peerlinck and Marc Jacquemin (Belgium).3 Incidence and prevalence of inhibitors and type of blood product in haemophilia A.Christine Lee and Thynn Thynn Yee (UK).4 Genetic basis of inhibitor development in severe haemophilia A and B.Edward Tuddenham (UK) and Johannes Oldenburg (Germany)..MANAGEMENT OF TREATMENT.5 Therapeutic products: human FVIII, porcine FVIII, prothrombin complex concentrates, activated prothrombin complex concentrates and recombinant FVIIa.Thierry Lambert (France).6 Methods: plasmapheresis and protein A immuno-adsorption.Eric Berntorp (Sweden).7 Venous access in children with inhibitors.Rolf Ljund (Sweden).IMMUNETOLERANCE.8 Immunetolerance: high dose regimen.Hans Brackmann and Thomas Wallny (Germany) (To be agreed).9 Immunetolerance: low dose regimen.Eveline Mauser-Bunschotten (Netherlands).10 Immunotolerance and choice of concentrates.Wolfgang Kreutz (Germany).11 Immunetolerance regimen: the North America registry (To be agreed).Donna DiMichele (USA)..MEDICAL MANAGEMENT OF BLEEDING EPISODES.12 Treatment of bleeding episodes in children.Joan Tusell (Spain).13 General medical management of bleeding episodes: haemarthroses, muscle haematoma, mucocutaneous bleed, haematuria.Manuel Quintana (Spain).14 Life- and limb-threatening bleeding episodes and intracranial bleeds.Sam Schulman (Sweden)..INHIBITORS IN HAEMOPHILIA B.15 Inhibitors in haemophilia B patients.India Warrier (USA).16 Inhibitors in mild/moderate haemophilia.Charles Hay (UK).17 Acquired inhibitors to FVIII.Craig Kessler (USA)..MUSCULOSKELETAL ISSUES.18 Pathogenesis of musculoskeletal complications of haemophilia.E C Rodriguez-Merchan (Spain).19 Orthopaedic management of haemarthroses.E C Rodriguez-Merchan (Spain).20 Synoviorthesis with Rifampicin.Horacio Caviglia (Argentina) and F Fernandez-Palazzi (Venezuela).21 Radiosynoviorthesis.Eric Berntorp (Sweden).22 Musculoskeletal MRI.Rachel Nuss and Jerome Wiedel (USA).23 Iliopsoas haematomas and limb compartment syndromes.Michael Heim (Israel).24 Pseudotumours.Marvin Gilbert (USA).25 Haemophilia patients with inhibitors: a rheumatologist´s point of view.John York (Australia).26 Rehabilitation.Felipe Querol and José Aznar (Spain).27 Physiotherapy.Karen Beeton (UK).28 Elective orthopaedic surgery in patients with high responding inhibitors-.Ivan Hvid, J Soballe and J Ingerslev (Denmark)..GENERAL SURGERY.29 General and emergency surgery in patients with high responding inhibitors.Owen Smith & Barry White (Ireland).30 Dental extractions.Uri Martinowitz (Israel)..PSYCHOSOCIAL ISSUES.31 Psychological issues.Pilar Arranz (Spain)..32 GENERAL STRATEGY FOR MANAGEMENT OF INHIBITOR PATIENTS.Inga Scharrer (Germany).Index

E. C. Rodriquez-Merchan is the editor of Inhibitors in Patients with Haemophilia, published by Wiley. Christine A. Lee is the editor of Inhibitors in Patients with Haemophilia, published by Wiley.

• Contributors. Preface.HAEMATOLOGY.1 Natural history of inhibitor in severe haemophilia A and B: incidence and prevalence.Jeanne Lusher (USA).2 Characterisation of inhibitors in congenital haemophilia.Kathelijne Peerlinck and Marc Jacquemin (Belgium).3 Incidence and prevalence of inhibitors and type of blood product in haemophilia A.Christine Lee and Thynn Thynn Yee (UK).4 Genetic basis of inhibitor development in severe haemophilia A and B.Edward Tuddenham (UK) and Johannes Oldenburg (Germany)..MANAGEMENT OF TREATMENT.5 Therapeutic products: human FVIII, porcine FVIII, prothrombin complex concentrates, activated prothrombin complex concentrates and recombinant FVIIa.Thierry Lambert (France).6 Methods: plasmapheresis and protein A immuno-adsorption.Eric Berntorp (Sweden).7 Venous access in children with inhibitors.Rolf Ljund (Sweden).IMMUNETOLERANCE.8 Immunetolerance: high dose regimen.Hans Brackmann and Thomas Wallny (Germany) (To be agreed).9 Immunetolerance: low dose regimen.Eveline Mauser-Bunschotten (Netherlands).10 Immunotolerance and choice of concentrates.Wolfgang Kreutz (Germany).11 Immunetolerance regimen: the North America registry (To be agreed).Donna DiMichele (USA)..MEDICAL MANAGEMENT OF BLEEDING EPISODES.12 Treatment of bleeding episodes in children.Joan Tusell (Spain).13 General medical management of bleeding episodes: haemarthroses, muscle haematoma, mucocutaneous bleed, haematuria.Manuel Quintana (Spain).14 Life- and limb-threatening bleeding episodes and intracranial bleeds.Sam Schulman (Sweden)..INHIBITORS IN HAEMOPHILIA B.15 Inhibitors in haemophilia B patients.India Warrier (USA).16 Inhibitors in mild/moderate haemophilia.Charles Hay (UK).17 Acquired inhibitors to FVIII.Craig Kessler (USA)..MUSCULOSKELETAL ISSUES.18 Pathogenesis of musculoskeletal complications of haemophilia.E C Rodriguez-Merchan (Spain).19 Orthopaedic management of haemarthroses.E C Rodriguez-Merchan (Spain).20 Synoviorthesis with Rifampicin.Horacio Caviglia (Argentina) and F Fernandez-Palazzi (Venezuela).21 Radiosynoviorthesis.Eric Berntorp (Sweden).22 Musculoskeletal MRI.Rachel Nuss and Jerome Wiedel (USA).23 Iliopsoas haematomas and limb compartment syndromes.Michael Heim (Israel).24 Pseudotumours.Marvin Gilbert (USA).25 Haemophilia patients with inhibitors: a rheumatologist´s point of view.John York (Australia).26 Rehabilitation.Felipe Querol and José Aznar (Spain).27 Physiotherapy.Karen Beeton (UK).28 Elective orthopaedic surgery in patients with high responding inhibitors-.Ivan Hvid, J Soballe and J Ingerslev (Denmark)..GENERAL SURGERY.29 General and emergency surgery in patients with high responding inhibitors.Owen Smith & Barry White (Ireland).30 Dental extractions.Uri Martinowitz (Israel)..PSYCHOSOCIAL ISSUES.31 Psychological issues.Pilar Arranz (Spain)..32 GENERAL STRATEGY FOR MANAGEMENT OF INHIBITOR PATIENTS.Inga Scharrer (Germany).Index