Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA

AvKenneth V. Honn,Lawrence J. Marnett

Inbunden, Engelska, 1991

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Beskrivning

This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The conference was unique in its forging of a link between the eicosanoid and lipid researchers in the disciplines of radiobiology and cancer. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena, including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated a scientific interaction to sort out and understand these complex and sometimes contradictory observations. The scope of this volume encompasses the complete range of eicosanoid studies in these two fields, beginning with discussions of improved means of detecting eicosanoids using radioimmunoassays, high performance liquid chromatography, and GC-mass spectrometry and including specialized assays of the enzyme system involved in the metabolism of the bioactive lipids.Studies on the mechanistic basis of bioactive lipids in carcinogenesis and radiation injury have been conducted in vitro in biochemical assays and cell culture, culminating in observations in vivo, including applications in the treatment of cancer patients.

Produktinformation

Utgivningsdatum:1991-07-31
Mått:155 x 235 x 34 mm
Vikt:980 g
Format:Inbunden
Språk:Engelska
Serie:Developments in Oncology
Antal sidor:512
Upplaga:1991
Förlag:Kluwer Academic Publishers
ISBN:9780792313038

Utforska kategorier

Onkologi inom Medicin

Recensioner i media

' The paradoxical roles of eicosanoids (stimulation/inhibition of injury processes) are the primary subjects of the investigations reviewed in this book. It will be of great interest to both researchers and clinicians.' Annals of Oncology 3:10 1992

Innehållsförteckning

Phospholipid turnover oxygenases and fatty acid metabolism.- Radiation and Chemical Carcinogenesis.- Lipid Peroxidation, Eicosanoid biosynthesis, and Radiation induced tissue injury.- Antioxidant Enzyme Action.- Dietary lipid actions.- Immunomodulation.- Receptor Modulation of lipid Metabolism.- Eicosanoid Modulation of receptor Expression.- Tumor Growth invasion and differentiation.- Effects of Eicosanoid analogs on tumor growth and Metastasis.- Paf & Ether lipids - Role in radiation injury and tumor growth.- Clinical Implications.

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