Developments in Oncology – serie
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133 produkter
133 produkter
Breast Cancer: Progress in Biology, Clinical Management and Prevention
Proceedings of the International Association for Breast Cancer Research Conference, Tel-Aviv, Isreal, March 1989
Inbunden, Engelska, 1989
1 654 kr
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In breast cancer as in other cancers on the front line of modern interdisciplinary research we have crossed the threshhold of new understanding. Fueled by an awareness that breast cancer is a leading cause of morbidity and mortality in women and honed by rapid technological advances in molecular mechanisms, major inroads into the darkness of this scourge have been accomplished during the past several years. Basic laboratory and clinical research findings must influence and in turn be influenced by efforts to detect, to diagnose and to cure the human disease. It is indeed gratifying to note that the efforts of scientists and clinicians from throughout the world reported in this volume are achieving this objective. The first section of the book focuses on the molecular and genetic basis of breast cancer. The role of specific oncogenes in mammary tumorigenesis using transgenic mice and mammary glands correlating molecular events with specific stages in neoplastic development are described and discussed. Such topics as the nature of specific oncogenes, levels of oncogene expression, the alteration of expression of other growth regulatory genes and the state of the cell in which the oncogene is expressed are specifically addressed. This section of the book is rounded out with discussions on the potential of genetic alterations as indicators of prognosis, the characterization of full-length cDNA codes for breast cancer markers and the function of antigens in tuomorigenesis.
Radiation Oncology: Radiobiological and Physiological Perspectives
The boundary-zone between clinical radiotherapy and fundamental radiobiology and physiology
Inbunden, Engelska, 1990
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During the past four decades knowledge about biological effects of ionizing radiations on mammalian cells, normal tissues and tumours has increased enormously and has enabled radiotherapists to obtain a better insight into the advantages and disadvantages of cancer treatments with modified regimens of irradiations and combinations with chemotherapeutic agents. Even for the older scientists and clinicians who have wit nessed all these developments and have contributed to the vast amount of information, it is difficult to integrate this knowledge and to apply it in their daily work. For younger workers it is often difficult to select the important main concepts and results from the overwhelming number of publications. It is evident that a book which provides an integrated view of basic and applied radiation oncology can be of great value to students, scientists and, most importantly, to clinicians who can devote only part of their time to the task of understanding the radiobiological background of their application of radiation in cancer treatment. This book "Radiation Oncology" is written by a radiotherapist who has for a long time participated in the integration of basic knowledge and clinical experience. He has selected radiobiological information which is considered important to radiotherapy and in the description and interpretation of normal tissue tolerance and tumour eradication probability, he illustrates how basic knowledge can be applied clinically.
Magnetic Resonance in Experimental and Clinical Oncology
Proceedings of the 21st Annual Detroit Cancer Symposium Detroit, Michigan, USA — April 13 and 14, 1989
Inbunden, Engelska, 1990
2 203 kr
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Over the past decade, techniques have been developed and implemented to observe metabolism noninvasively in localized regions of intact, living experimental animals and humans through the use of magnetic resonance spectroscopy (MRS). At the same time, magnetic resonance imaging (MRI) techniques developed in the 1970s and refined in this decade have been increasingly applied as a powerful clinical tool to probe human anatomy. Because of the unusual metabolic and physiologic characteristics of malignant tissues, oncology has been one of the primary focuses of the application of both MRS and MRI. Although considerable progress has been made in oncologic applications of magnetic resonance (MR), further research is needed to realize the full potential of MR in this area. Consequently, the 21st Annual Detroit Cancer Symposium entitled "Magnetic Resonance in Experimental and Clin ical Oncology" was organized to provide a forum for researchers in the field to report the state of the art of MRS and MRI in oncol ogy, to discuss future goals for MRS and MRI in oncology, and to define the research needed to meet those goals. The major emphasis of the symposium was on MRS due to both the recent widespread availability of clinical MRS instrumentation and the extensive amount of animal MRS research performed over the past half decade.
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This book is a logical companion volume to Women at High Risk to Breast Cancer (Kluwer, 1989) edited by me previously. It distinguishes two aspects of current ap proaches to clinical breast cancer prevention. The first is the need to advise individ ual women on how they might reduce their personal risk, while the second is the design of measures aimed at reducing the total incidence of breast cancer in the community. While the former is a problem faced daily by clinicians, the latter is a goal which will involve large scale, carefully planned interventional studies. Because knowledge of the risk factors for breast cancer is incomplete and clinical trial reports are scarce, there is as yet, no scientifically-based model for personal breast cancer prevention. Nevertheless, widespread publicity associated with breast screening programmes has created a large group of highly anxious women who have been informed that they are at higher than average risk to the disease. They are con cerned by the personal threat posed by a family history of the disease and by the al leged dangers of obesity, diet, alcohol, or the use of hormonal agents such as oral contraceptives or hormone replacement therapy.
Causation and Prevention of Human Cancer
Proceedings of the 8th Annual Symposium of the European Organization for Cooperation in Cancer Prevention Studies (ECP), Heidelberg, Germany, April 2–3,1990
Inbunden, Engelska, 1991
1 105 kr
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The European Organization for Cooperation in Cancer Prevention Studies (ECP) was established in 1981 to promote collaboration between scientists working in the various European countries on cancer causation and prevention. In order to achieve this aim, various working group- to deal with specific cancers or aspects of cancer aetiology, and to explore the opportunities for advances on a cooperative European basis - were established. It was also decided to hold annual symposia to draw general attention to fields in which there seemed to be many opportunities for progress in matters of prevention. These symposia have been devoted to themes of high priority to cancer prevention: "Tobacco and Cancer" (1983), "Hormones and Sexual Factors in Human Cancer Aetiology" (1984), "Diet and Human Carcinogenesis" (1985), "Concepts and Theories in Carcinogenesis" (1986)," Preventive Strategies for Cancer related to Immune Deficiencies" (1987), "Gastric Carcinogenesis" (1988), and "Breast, Ovarian and Endometrial Cancer: Aetiological and Epidemiological Relationships" (1989). This volume contains the proceedings of the 1990 ECP symposium held in Heidelberg, FRG, at the Deutsches Krebsforschungszentrum (DKFZ), on April 2-3 on "Causation and Prevention of Human Cancer". We are indebted to the speakers for their contribution during the symposium and for their prompt submission of manuscripts. We are grateful to the sponsors, SmithKline Diagnostics and Rohm Pharma. Our special thanks go to Dr M.C. stanei-Gueur for preparing and typing the camera forms of all manuscripts.
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Childhood Leukemia: Present Problems and Future Prospects
Proceedings of the Second International Symposium on Children#x2019;s Cancer Tokyo, Japan, December 7–9, 1989
Inbunden, Engelska, 1991
1 654 kr
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Twenty years ago when Children's Cancer Association of Japan was born, the diagnosis of childhood leukemia amounted to a death sentence. Only 20% or so of children with leukemia survived more than 5 years. Since then, enormous improvements have been achieved regarding our understanding on the etiology, diagnosis, and the treatment of childhood leukemia. Now, 70% of children with leukemia survive and enter adult life. Even though the improved survival rate of children with leukemia represents a medical success story, we now face new problems. The first problem is the fact that we still lose 20-30% of patients with childhood leukemia. To address this problem, we need to understand the etiology, epidemiology, and biology of leukemia; to identify the patients at greater risk; and to develop adequate treatments. The second problem is the treatment itself. Even though efficacious, the modem treatment for leukemia is a grueling experience for children and their families. We should develop a total care system for families and children based on a deep understanding of their needs. The third problem is the aftereffects of the treatment and of cured leukemia. Extensive radiation and chemotherapy have an entirely different spectrum of long-term effects on children than on adults. These treatments in the early stage of life, when the mind and body are developing, create many physical and psychological problems. These are the present problems of childhood leukemia.
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This volume focuses on the present state of biological research as well as the diagnosis and treatment of nervous system neoplasia. The section concerning 'Biology and Diagnosis' describes the aspect related to brain tumour classification and neuro-radiological diagnosis. Papers on oncogenes and growth factor expression are also included. The role of surgery, radiotherapy and chemotherapy, as well as new therapeutic approaches, is described in the section on 'Therapy of Gliomas'. "Neuro-Oncology" presents an up-to-date review of research on biological studies and the treatment of meningiomas, neuronomas, craniopharingiomas, pinealomas, metastatic tumours, and cerebral tumours in children written by some of the most respected neurosurgeons in the world. The book is recommended not only to neurosurgeons and neurologists, but also to all researchers actively working in the field of neuro-oncology.
Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury
Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA
Inbunden, Engelska, 1991
2 203 kr
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This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The conference was unique in its forging of a link between the eicosanoid and lipid researchers in the disciplines of radiobiology and cancer. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena, including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated a scientific interaction to sort out and understand these complex and sometimes contradictory observations. The scope of this volume encompasses the complete range of eicosanoid studies in these two fields, beginning with discussions of improved means of detecting eicosanoids using radioimmunoassays, high performance liquid chromatography, and GC-mass spectrometry and including specialized assays of the enzyme system involved in the metabolism of the bioactive lipids.Studies on the mechanistic basis of bioactive lipids in carcinogenesis and radiation injury have been conducted in vitro in biochemical assays and cell culture, culminating in observations in vivo, including applications in the treatment of cancer patients.
Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development
Proceedings of the Twenty-Second Annual Cancer Symposium Detroit, Michigan, USA — April 26–28, 1990
Inbunden, Engelska, 1992
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The focus of the 22nd Annual Detroit Cancer Symposium was the presentation and discussion of cytotoxic agents, with a significant portion of the symposium including the frontiers of drug discovery being explored by the National Cooperative Drug Discovery Groups (NCDDG) Program. The symposium brought together investigators from government, universities and pharmaceutical companies involved in the discovery and development of new anticancer agents. New leads were presented and the status of others presently under development was discussed. Of particular significance has been the initiation of renewed efforts in the area of natural product drug discovery, where the discovery of new cytotoxics is very promising at the moment. A number of major changes have occurred during the last decade in research on drug discovery of cytotoxic agents. Critical reviews of a number of the models and concepts underlying drug discovery represented a continuous thread throughout the meeting, being constantly discussed in terms of their advantages, disadvantages and capabilities of discovering solid tumour active anticancer agents.A recent development which portends to great discoveries is the new relationship formed between Government, University and Industry. The NCDDG mechanism which stimulates this interaction is an inexpensive manner to greatly magnify the drug discovery and development effort nationally. "Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development" represents a forum for these three different components in the equation to regularly discuss new results and ideas.
Breast Cancer: Biological and Clinical Progress
Proceedings of the Conference of the International Association for Breast Cancer Research, St. Vincent, Aosta Valley, Italy, May 26–29, 1991
Inbunden, Engelska, 1992
1 654 kr
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The fight against breast cancer is expected to be effectively stimulated by interdisciplinary approaches and cross-fertilization between laboratory and clinical research findings. Of major importance, therefore, are meetings that promote rapid transfer to clinical applications of findings by basic scientists. This volume reports the proceedings of the 1991 Biennial Conference of the International Association for Breast Cancer Research and seeks to achieve this goal by presenting the most recent observations in the laboratory and their possible applications for diagnostic evaluations and clinical treatments. The sections in this book focus first on the oncogenes more likely involved in mammary tumorigenesis and on the polypeptide factors and steroid hormones affecting proliferation and possible inducing carcinogenesis in breast epithelium. A section is devoted to the epidemiological studies and to the identification of risk factors; a way to select populations at higher risk and, possibly, to help in preventing the disease.Special emphasis is given to the establishment of diagnostic criteria and to the selection of prognostic factors, which must support an effective therapeutic planning.
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury
Proceedings of the 2nd International Conference September 17–21, 1991 Berlin, FRG
Inbunden, Engelska, 1992
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In recent decades, eicosanoids have been attracting an increasing amount of attention as a result of their important physiological roles in many areas of biology and medicine. The eicosanoids comprise the prostaglandins, thromboxanes and leukotrienes and are products of arachidonic acid, an essential polyunsaturated fatty acid stored in tissue phospholipids. Disturbances of eicosanoids and their metabolic products play a regulatory role in many types of cell injuries and diseases. One of the most exciting areas of eicosanoid research pinpoints their participation in the control of cell proliferation and differentiation. Eicosanoids form a link between different fields of research into such areas as cancer, inflammation and radiation-induced injury. This link provided the impetus for the development of the conference series of which this volume represents the proceedings of the Second International Conference, held in Berlin in October 1991.
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Colorectal cancer is a collective term for a heterogeneous group of diseases. In a large proportion of cases, the condition is attributable to genetic predisposition. Those directly involved in the treatment of patients with cancer of the large bowel are confronted to an increasing degree with the genetic aspects of the disease. In familial and hereditary forms of the disorder, periodic screening of the close relatives of the patients can, in principle, prevent disease and death from colorecial cancer. Presymptomatic diagnosis by means of DNA technology is now possible in many cases of familial adenomatous polyposis. Genetic diagnosis will be increasingly important for the identification of high-risk groups. This book summarizes those aspects of the genetics of colorectal cancer that are important for clinical practice. lt has been stated that clinicians can contribute to the goal of reducing mortality from cancer by asking each patient about his or her family history of cancer. The aim of this book is to provide a guideline for the management of those situations in which the family history of colorectal cancer is found to be positive.
Anticancer Drug Discovery and Development: Natural Products and New Molecular Models
Proceedings of the Second Drug Discovery and Development Symposium Traverse City, Michigan, USA — June 27–29, 1991
Inbunden, Engelska, 1994
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With the publication of these proceedings from the Second Drug Discovery and Development Symposium, this forum has become the main mechanism for bringing together the principal groups involved in both discovering and developing new approaches to the treatment of cancer. This second symposium emphasized the types of materials being discovered and their therapeutic activity. This is especially evident in the natural product discovery programs, where unique and active structures are being identified. The major contributors to the meeting were the investigators participating in the National Cooperative (Natural Products) Drug Discovery Groups (NC(NP)DDG). These groups reflect an association among researchers at universities or cancer centres, pharmaceutical companies and the National Cancer Institute. Their sources of materials are varied, reflecting chemical inventories of pharmaceutical companies, organic synthetic compounds from the laboratory, cytotoxics, as well as biologics and their hybrids, and natural products obtained from plants, marine organisms and micro-organisms.The models employed in the discovery systems vary from broadly cellular-based to specific enzymes to defined cellular functions. Each of them is believed important to the malignant state and will allow for the discovery of compounds which will have efficacy in cancer therapy. The goal of the participants is both to discover new anti-cancer agents and to develop them as efficiently as possible into clinically useful additions to treatment. Of importance is the fact that there are a number of promising leads which will soon be moving into the clinic, thereby testing the effectiveness of this NC (NP) DDG approach.
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Breast cancer is not only a burning public issue, but very soon we shall see genetic testing for a woman's predisposition to breast cancer. Many women will be demanding to know their degree of risk and will need counselling to cope with that information. This book is particularly aimed at primary health care professionals, including physicians, medical assistants, nurses and counsellors, who daily deal with questions from women concerned about their risk of developing breast cancer. To answer such questions, this book has combined a guide to identifying women at higher risk to breast cancer, with a balanced review of approaches which aim to reduce that risk. The book provides practical general measures which may reduce risk for women at average risk. For women at clearly increased risk various protective options with different levels of efficacy and acceptability are discussed. Central to the book is the patient-centered view. We need to face reality that it still will take many years before the current clinical trials of preventive measures provide meaningful results.
Basic and Clinical Applications of Flow Cytometry
Proceeding of the 24th Annual Detroit Cancer Symposium Detroit, Michigan, USA - April 30, May 1 and 2, 1992
Inbunden, Engelska, 1995
1 654 kr
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The focus of this symposium was on the present and future capabilities of flow cytometry for both medical and biological applications in cancer. This technology began with quite modest instrumentation, with limited capabilities to answer biological questions. Today, both the clinical workhorses and the powerful multi-laser, multi-detector, sorting machinery, coupled with sophisticated computers and storage devices and the increasing storehouse of markers and dyes, are helping to find answers to the cause and cure of cancer. In the past, both normal hematopoietic tissue and leukemias have been the tissue samples of choice in the application of flow cytometry, and some of the most recent applications with these tissues are presented here. However, the book also discusses the increasingly sophisticated disaggregation techniques which allow investigators the possibility to train their lasers on solid tumours.Not only can we use flow cytometry with associated fluorescent markers to understand the biology of cancer, but also the wide array of existing and developing markers provides us with important diagnostic tools in the detection of cancer early in either the malignant or relapse process. And the field comes full circle, with the use of the technology for gene mapping and other genetic studies to unlock the basic malignant process.
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This monograph takes a global, multidisciplinary approach to the causes, carcinogenesis and control of colorectal cancer. Over 1000 key studies were analyzed on colorectal cancer cause, carcinogenesis, primary prevention, early detection using modern screening techniques, and surveillance after tumour excision. The key chapters include those on morphology, molecular biology and evolution of tumours. Etiology chapters cover heredity, diet, alcohol, smoking, physical activity, life stress and others, while major chapters in the area of colorectal cancer control are on primary prevention, early detection by screening and surveillance, and post-tumour excision surveillance. Important recommendations on primary prevention, screening and surveillance of colorectal tumours are made in keeping with the most current research data. The work suggests colorectal cancer to be the first cancer in which control will be largely achieved within the next generation, as a result of the unprecedented multidisciplinary research into causation, primary prevention, screening and surveillance over the past 30 years.The book also serves as a model for the control of other common malignancies, particularly cancers of the breast and prostate, the causes and prevention of which are less well understood.
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Despite progress in many areas of treatment and control, cancer remains a frightening threat to everyone. While scientists have known for decades that the majority of human cancers are caused by environmental agents such as radiation and the chemicals in cigarette smoke, not everyone who smokes gets lung cancer. Furthermore, many people who assiduously avoid all possible risk from smoking, diet, and pollution still succumb to some form of cancer later in life. Does this mean that there is an element of blind chance in the underlying mechanisms of human carcinogenesis? To what extent do genetic influences play a role in determining the cancer risk of individuals? A number of "cancer families", in which several closely-related individuals have suffered from various specific forms of cancer, have been studied by genetic epidemiologists. However, for the majority of cancer cases, little or no discernible genetic influence or family history is found. This text explains that this idea of "bad genes" may contain an unexpected positive side.The carcinogenic effects of these metabolic genes, unlike those of the oncogenes and tumour suppressor genes that are responsible for the inherited cancer syndromes, can potentially be overcome or nullified. This volume should provide a useful reference for health professionals, researchers, clinicians and biomedical scientists who are interested in the current thinking in this critically important area of cancer management.
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The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off invading microbes by humoral, cell-mediated, and phagocytic immunity. Today several growth factors are available to the clinician as treatments for various pathologic perturbations of hematopoiesis. Their use has also advanced our capacity to safely deliver cancer chemotherapy. Hematopoietic growth factors have become an everyday tool for the practicing oncologist. Here, experts review the biological interactions between hematopoietic progenitors, growth factors and cytokines, and the stromal micro-environment that have provided the scientific basis for our current understanding of hematopoiesis. In subsequent sections the pathophysiology of neutropenia, anemia and thrombocytopenia are presented, along with discussions of the clinical challenges these pose for the practicing oncologist and hematologist and the roles of various hematopoietic growth factors in therapeutic strategies for these entities.
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Despite the fact that the incidence of gastric cancer is declining in the Western world, it remains a significant problem with respect to accurate diagnosis and treatment since it has a high mortality rate. In June 1989 an International Conference was held at the University of Rome "La Sapienza" entitled "New Trends in Gastric Cancer: Background and videosurgery". During this meeting background information on the aetiopathogenesis of gastric cancer was presented together with talks and video presentations on the latest advances in the treatment of gastric carcinoma, both from the European and Japanese experience. Because of the poor prognosis of gastric carcinoma there is increasing pressure for early detection. Some of the problems in the early detection of gastric carcinoma are discussed together with methods of surveillance of high-risk subjects. It is generally accepted that the surgical approach to gastric carcinoma should take into account the site and extent of the lesion and there are chapters on new methods for pre and intraoperative staging of the disease which allow a more logical approach to surgery. A comparison between Japanese and Western rule and results was attempted and reasons for the differences were investigated. Since the field is still evolving not all aspects could be covered, and those angles not approached in this book will be addressed in a second International Conference to be held in Rome in June 1990.
Public Education on Diet and Cancer
Proceedings of the 9th Annual Symposium of the European Organization for Cooperation in Cancer Prevention Studies (ECP), Madrid, Spain, October 17-19, 1991
Inbunden, Engelska, 1992
885 kr
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This book evaluates new data on diet and cancer and uses it to update the dietary guidelines produces by ECP and IUNS in 1985. It is the proceedings of the 9th Annual Symposium of the European Organization for Cooperation in Cancer Prevention Studies held in Madrid during October, 1991. The first section updates general background material (dietary carcinogens, animal studies), the second section concerns diet and cancer at specific sites and also specific nutrients in human cancer. The third section addresses problems with guidelines per se and the fourth the Mediterranean diet in relation to cancer. These chapters, together with the general conclusions reached in a parallel workshop, represent a review of the current status of diet and cancer and also provides the background to the conclusions that guidelines as formulated in 1985 can no longer be sustained and that they need to be replaced by guidelines that concern food groups instread of nutrients and are targetted at particular groups rather than at the population in general.
Organ Directed Toxicities of Anticancer Drugs
Proceedings of the First International Symposium on the Organ Directed Toxicities of the Anticancer Drugs Burlington, Vermont, USA-June 4–6, 1987
Inbunden, Engelska, 1988
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The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in tervention. Much of this toxicity, such as damage to the bone marrow, gastroin testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre dicted toxicities are usually irreversible or only partially reversible upon cessation of drug administration. Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.
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Proceedings of the Fifth International Symposium, held in Abano Terme (Padova), italy, June 29-July 2, 1987
Recent Concepts in Sarcoma Treatment
Proceedings of the International Symposium on Sarcomas, Tarpon Springs, Florida, October 8–10, 1987
Inbunden, Engelska, 1988
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There have been significant advances in the treatment of sarcomas in the past several years. Further, different clini cal treatment programs are being advocated in different areas including surgery alone, surgery with preoperative or post operative chemotherapy, surgery with different radiotherapy modalities, with each investigator espousing his own treat ment program. On the other side, there is the question of whether these treatment programs are offering better results or whether the natural history of sarcomas has changed. The International Symposium on Sarcomas was held at Innisbrook Resort, Tarpon Springs, Florida, October 8-10, 1987. This was the first international symposium to date involving all of the disciplines treating sarcomas including pathologists, orthopaedic surgeons, general surgeons, medical oncologists, pediatric oncologists, and radiation oncol ogists. The Symposium brought together a number of special ists working in the clinical field of sarcomas for a presen tation of their specific treatment programs and their results. The presentations were followed by panel discussions to stimulate educational debate as to the different forms of treatment for sarcomas and to formulate some conformity in control of disease, control of spread, and ultimate function for the patient. James R. Ryan, M.D.
Breast Cancer: Scientific and Clinical Progress
Proceedings of the Biennial Conference for the International Association of Breast Cancer Research, Miami, Florida, USA — March 1–5, 1987
Inbunden, Engelska, 1988
2 203 kr
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Effective control of breast cancer depends on three types of research accomplishment -- understanding the disease's origins and progression: successfully applying this knowledge to methods of detection, diagnosis and treatment: and finding ways to make these advances truly available to the public as effectively as possible. The significant progress that is occurring across this entire spectrum of pioneering investigation is reflected in these proceedings of the 1987 biennial conference of the International Association for Breast Cancer Research. The first section of the book focuses on oncogenes and chemical effectors that may play key roles in early cell transformation leading to breast cancer. Research discussed includes identification of specific oncogenes which appear to be involved in the disease, study of their activation and expression, examination of the biological effects of various growth factors isolated from breast cancer cell lines, and investigation of the molecular mechanisms by which estrogens promote and stimulate growth of breast cancers. The second group of chapters deals with several other complex factors and phenomena which may influence tumor formation in the breast, for example, expression of abnormalities by fibroblasts, disruption of epithelial-mesenchymal interactions, and loss of ability nili to synthesize normal basal lamina resulting in alterations in the extracellular matrix. Clarification of the processes of normal mammary gland development and differentiation is central to much of this work.
Human Leukemias
Cytochemical and Ultrastructural Techniques in Diagnosis and Research
Inbunden, Engelska, 1984
1 654 kr
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In recent years excellent progress has been the study of these disorders in the future. made in the development of improved Recently freeze fracture techniques have cytochemical and ultrastructural tech- also been employed in the study of normal niques for electron microscopy in hematol- and leukemic lymphocytes and much new ogy and in particular in leukemia and information concerning leukemic cell lymphoma. Subtypes of these disorders, membranes may be obtained from the use which are essentially classified according to of this technique in the future. cell phenotype and the degree of matura- The purpose of this book is to demon- tion, can be well defined today using a strate the utility of these techniques in combination of immunological methods, defining leukemic cell types and to illus- light microscopy, cytochemistry, and elec- trate the potential of some of the newer tron microscopy.Ultrastructural cyto- ultrastructural methods, including trans- chemistry is now utilized routinely in mission and scanning immuno electron leukemia in most major centers today and microscopy, SEM cytochemistry, and can also be performed using scanning elec- freeze fracture techniques, in the study of tron microscopy (SEM), as described in leukemia. Advances in cytochemical tech- this book. Immuno electron microscopy niques and their use in the definition of used with or without simultaneous ultra- nonlymphoid cells and in the classification structural cytochemistry can also be em- of lymphoid subtypes are clearly demon- ployed in the accurate classification of strated in this book.
Del 15 - Developments in Oncology
Control of Tumour Growth and Its Biological Bases
Inbunden, Engelska, 1984
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Rat as Animal Model in Breast Cancer Research
A histopathological study of radiation- and hormone-induced rat mammary tumors
Inbunden, Engelska, 1984
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A multidisciplinary approach to the problems related to the diagnosis, treat ment, and rehabilitation of patients with oral cancer and precancer is reflected in the various specialties of the authors who contributed to this book. Today, patients with tumors of the oral cavity are dealt with preferably by a team of specialists who have been properly trained in the field of oncology, who have learned to appreciate each other's knowledge and experience, and who are able to operate as an integrated team. This book is intended for use by every physician and dentist involved in the diagnosis and management of oral cancer. It is 'presented in such a way as to be useful for both the physician in training as well as the specialist in the field of head and neck oncology. The text concentrates on the common as well as the unusual aspects. For those who look for more detailed information, an exten sive list of references is provided at the end of each chapter. It should be emphasized that treatment policies may vary not only in differ ent parts of the world, but also from institution to institution, depending on the expertise of the members of the oncologic team and the available facilities. I. VAN DER W AAL AND G. B. SNOW, editors.
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