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The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilized as a fast, cheap, and accurate drug screening instrument.
From Genes to Drugs.- Ca2+ Release in Muscle Cells.- Calcium Signalling in Neurons Exemplified by Rat Sympathetic Ganglion Cells.- Calcium and Platelets.- Calcium Signalling in Liver Cells.- Intercellular Calcium Signalling in “Non-Excitable” Cells.- The Ca2+-Mobilizing Second Messenger Cyclic ADP-Ribose.- Visinin-Like Proteins (VILIPs) — Emerging Role in Cross-Talk between Cellular Signaling Pathways.- Calcium Binding to Extracellular Matrix Proteins, Functional and Pathological Effects.- The Extracellular Calcium-Sensing Receptor: Molecular Features, Distribution and Its Roles in Physiology and Disease.- Regulation of Inositol 1,4,5-Triphosphate-Induced Ca2+ Release by Ca2+.- Calreticulin and Dynamics of the Endoplasmic Reticulum Lumenal Environment.- Ryanodine-Sensitive Calcium Release Channels.- Calcium Inhibition of Cytoplasmic Streaming.- Penta-EF-Hand (PEF) Proteins and Calsenilin/DREAM: Involvement of the New EF-Hand Calcium-Binding Proteins in Apoptosis and Signal Transduction.- Activation of Programmed Cell Death by Calcium: Protection against Cell Death by the Calcium Binding Protein, Calbindin-D28k.- Calcium and Cellular Ageing.- The Epidermal Growth Factor Receptor and the Calcium Signal.- Annexinopathies.- Autoimmune Disease and Calcium Binding Proteins.- Calcium Antagonists and Calcium Sensitizers.- Calcium-Binding Proteins in Type I Allergy: Elicitors and Vaccines.- Calcium Channelopathies in Nervous System.- Calcium and Diabetes.- Inherited and Acquired Disorders of Extracellular Calcium (Ca02+)-Sensing.- Calcium and Muscle Disease: Pathophysiology of Calpains and Limb-Girdle Muscular Distrophy Type 2a (LGMD2A).- Role of Calcium Channels in Drug Dependence.- S100 Proteins and Fatty Acid Transport Are Altered in Skin Diseases.- Calcium-BindingProteins in Degenerative and Cancer-Related Diseases of the Eye.- Calcium ATPases Genes and Cell Transformation.- Interaction of Dimeric S100B (??) with the Tumor Suppressor Protein p53: A Model for Ca2+-Dependent S100-Target Protein Interactions.- The Interaction of Calmodulin with Novel Target Proteins.- Type II Citrullinemia (Citrin Deficiency): A Mysterious Disease Caused by a Defect of Calcium-Binding Mitochondrial Carrier Protein.- High Calcium Concentrations, Calpain Activation and Cytoskeleton Remodeling in Neuronal Regeneration after Axotomy.- Genetic Factors and the Role of Calcium in Alzheimer’s Disease Pathogenesis.- The Role of Intracellular Calcium Signaling in Motoneuron Function and Disease.- Pharmaceutical Chemistry and Drug Screening.- Calcium in Drug Screening.- Imaging Intracellular Calcium in Living Tissue by Laser-Scanning Confocal Microscopy.- Immature Mouse Oocyte as a Model for Imaging Nuclear Calcium Dynamics.- Single Cell Fluorescence Imaging to Investigate Signaling in Primary Cultured Neurones.- Calcium Complexities: New Fluorescence Techniques for Probing Mitochondria and Other Subcellular Compartments.
