McDonald’s Blood Flow in Arteries

Dr. Wilmer Nichols, PhD., is Emeritus Professor of Cardiovascular Medicine in the School of Medicine at the University of Florida in Gainesville, Florida. His career has been dedicated to the investigation of structure and function of the heart and arterial system in age and arterial disease. He has published over 200 articles in peer reviewed journals; books include the 6th edition of McDonald’s Blood Flow in Arteries. Among his many awards are Lifetime Achievement Awards from the Artery Society of Europe and the North American Artery Society.Dr. Michael O’Rourke, MD, DSc., is Professor of Medicine (Emeritus) at the University of New South Wales (UNSW) and a Cardiologist at St. Vincent’s Hospital, Sydney. His basic research training was in arterial hemodynamics, working on experimental animals and computer models with Michael Taylor (Sydney) and William Milnor (Baltimore). He has published over 500 articles in peer reviewed journals; books include the 6th edition (2011) of McDonald’s Blood Flow in Arteries. Recent research is into cardiovascular aging, using new methods of pulse waveform analysis to detect, explain and treat ill-effects on the heart and brain from midlife in asymptomatic subjects.Dr. Elazer Edelman, MD, PhD., is the Edward J. Poitras Professor in Medical Engineering and Science at Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts where he directs the Institute of Medical Engineering and Science. He is also Professor of Medicine at Harvard Medical School, and a cardiac intensive care unit cardiologist at the Brigham and Women’s Hospital in Boston.Dr. Charalambos Vlachopoulos MD is Professor of Cardiology at the 1st Department of Cardiology, Hippokration Hospital, University of Athens Medical School with clinical interests in hypertension and interventional cardiology. Professor Vlachopoulos is currently Chairman of the European Society of Cardiology Working Group "Peripheral Circulation" and President of the Artery Society. Together with Wilmer Nichols and Michael O’Rourke he has authored the 6th Edition of "McDonald’s Blood Flow in Arteries". He has lectured extensively in international conferences. He is a member of the Board of Hypertension, Artery Research, and Hellenic Journal of Cardiology and a Reviewer for numerous Medical Journals.

This book is informationally sound with exquisite detail and focus on the physics of the cardiovascular system. - Kara E Gilliam, BA, MD/MPH Candidate, East Tennessee State University QuillenCollege of Medicine

• 1 Introduction2 Anatomy of the heart and circulation3 The nature of flow of a liquid4 Properties of the arterial wall: theory and practice5 Endothelial cells and hemodynamics6 General principles for measuring arterial waves7 Pulsatile pressure–flow relations8 Arterial wave reflections9 Contours of pressure and flow waves in arteries10 Principles of recording and analysis of arterial waveforms11 Vascular impedance12 Coupling of the left ventricle with the systemic circulation: implications to cardiac failure13 The pulmonary circulation and impedance14 The Specialized Circulations in Susceptible Tissues15 Aging16 Hypertension17 Interpretation of blood pressure in epidemiological studies and clinical trials18 Arterial biomarkers19 Arteriosclerosis and Atherosclerosis20 Specific arterial disease21 Generalized and metabolic disease22 Emergence of therapeutic strategies23 Endovascular implants24 Cardiovascular Effects of Exercise25 Central arterial pressure26 Lifestyle and environment27 Arterial pressure waveform analysis