Process Chemistry in the Pharmaceutical Industry

”...the book successfully achieves its goal of presenting the basic principles and challenges associated with the discovery and scale-up of a commercial manufacturing process of a new drug.”— Journal of Medicinal Chemistry”...gives a thorough overview of the challenges facing the modern development chemists in the pharmaceutical industry. It can be recommended to any graduates or postgraduates considering a career in this fascinating field, and even old hands will find much stimulating chemistry in the case studies. “— Organic Process Research & Development”...provides a good overview for those wanting an introduction to the science conducted in a process research group. For experienced process chemists, frequent descriptions of creative solutions to difficult problems makes the book worth reading.”— Journal of the American Chemical Society”...recommended without reservation. It is suitable not only for the process chemist but also for those involved in preparative work in research in teaching, and for advanced students. It should find a place in every chemical library.”— Angewandte Chemie”...presents pharmaceutical synthesis at its best in a very concise and educational way. The wealth of references and illustrations, and the carefully compiled subject index guarantees fast access to further information....the lively style in which chapters are written keeps the reader interested along the way.”— European Journal of Pharmaceutics and Biopharmaceutics, 2000

• OverviewProcess Chemistry in the Pharmaceutical Industry: An Overview, Kumar G. GadamasettiStrategyProcess Research and Development Strategy for Accelerated Projects, Christopher M. CimarustiCase StudiesA Practical Synthesis of Ifetroban Sodium, Richard H. MuellerSynthesis of 5-Lipoxygenase Inhibitors, Ivan Lantos and Richard MatsuokaChemistry of Vitamin D: A Challenging Field for Process Research, Masami OkabeA Highly Optimized and Concise Large Scale Synthesis of a Purine Bronchodilator, Hans-Jürgen Federsel and Edib JakupovicOntazolast: The Evolution of a Process, Vittorio Farina, Karl Grozinger, Hermann Müller-Bötticher and Gregory P. RothDilevalol Hydrochloride: Development of a Commercial Process, Derek WalkerDesign and Development of Practical Syntheses of LY228729, a Potent 5HT1a Receptor Agonist, Michael J. Martinelli and David L. VarieProcess Research and Development of CGS 19755, an NMDA Antagonist, Peter Giannousis, John Carlson and Marius LeimerRoute Evaluation for the Production of (R)-Levoprotiline, H. U. Blaser, R. Gamboni, B. Pugin, G. Rihs, G. Sedelmeier, E. Schaub, E. Schmidt, B. Schmitz, F. Spindler and Hj. WetterThe Process Research and Development of DuPont Merck’s Cyclic Urea Diols, A New Class of HIV Protease Inhibitors, Pat N. Confalone and Robert E. WaltermirePractical Enantio- and Diastereo-selective Processes for Azetidinones, T. K. Thiruvengadam, Anantha R. Sudhakar, and Guangzhong WuSynthesis of the Common Lactone Moiety of HMG-CoA Reductase Inhibitors, Ian M. McFarlane, Christopher G. Newton and Philippe PitchenEnzymatic Intervention and Phase Transfer CatalysisChemistry, Biocatalysis and Engineering: An Interdisciplinary Approach to the Manufacture of the Benzodiazepine Drug Candidate LY 300164, Benjamin A. Anderson, Marvin M. Hansen, Jeffrey T. Vicenzi and Milton J. ZmijewskiBenefits and Challenges of Applying Phase-Transfer Catalysis Technology in the Pharmaceutical Industry, Marc E. HalpernAsymmetric Synthesis and EnantioselectivityEnantioselective Synthesis: The Optimum Process, John J. Partridge and Brian L. BrayPractical Catalysts for Asymmetric Synthesis: Ligands from Natural Sugars for Rh-Catalyzed Asymmetric Synthesis of D- and L- Amino Acids, Timothy A. Ayers and T. V. Rajan BabuChiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical Synthesis of cis-Aminoindanol and Its Application to Enantiopure Drug Synthesis, Chris H. Senanayake and Eric N. JacobsenDrug Substance Final Form and Process SafetyChemical Development of the Drug Substance Solid Form, Michael D. Thompson and Jean-René AuthelinThe Basic Principles of Thermal Process Safety: Towards a Better Communication Between Safety Experts and Process Chemists, Wilfried HoffmannDesign of Experiments and AutomationUsing Factorial Experiments in the Development of Process Chemistry, Daniel R. PilipauskasLaboratory Automation in Chemical Development, Martin R. Owen and Sheila H. Dewitt