Gene Therapy for Neurological Disorders

Pedro R. Lowenstein, Maria G. Castro

• Immune Responses to Viral Vectors: Implications for Neurological Gene Therapy. Gene Transfer to the Nerve System Using HSV-1-Derived Amplicon Vectors. Adeno Associated Viral Vectors for the Nervous System. Heat Shock Proteins for Neurological Gene Therapy. iBAC Technologies for Neurological Disease. Targeted Gene Modification of the Nervous System. Astrocytes as Targets for Neurological Gene Therapy. Targeting Non-Viral Gene Transfer Vectors: What We Learn From Viruses & Other Pathogens. Gene Therapy Applications for Parkinson's Disease. HSV-Mediated Gene Transfer in the Treatment of Chronic Pain. Immunotherapeutic Approaches for Alzheimer's Disease. Gene Therapy of Multiple Sclerosis and in CNS Autoimmune Mouse Models. Novel Gene Therapeutic Approaches to Brain Cancer. Vaccines and Beneficial Immunity in Glioma Patients. Replicating Viruses for Brain Tumor Treatment. Adenovirus-mediated HSV-tk Gene Therapy for Malignant Glioma: Clinical Experience