Anemia of Chronic Disease

Gunter Weiss, Victor R. Gordeuk, Chaim Hershko

"…Clinicians will find the necessary diagnostic approach to this very common anemia, as well as several guides to its treatment and the related controversies."-New England Journal of Medicine

• Introduction. Anemia of Chronic Disease: The Enigma and the Challenge. BasicsRegulation of Iron Metabolism. Erythropoietin and Erythropoiesis. The Systemic Inflammatory Response. Pathophysiology. Disturbance of Iron Homeostasis: Iron Limited Erythropoiesis. Inhibition of Erythroid Progenitor Cell Proliferation. Blunted Response to Erythropoetin/Insufficient Erythropoeitin Synthesis. Erythrophagocytosis, Decreased Erythrocyte Survival. New Regulator Molecules in ACD. ACD-Rational: Is Anemia Part of the Body's Physiological Response To Inflammation? Iron Withholding as a Defense Strategy. Iron and Immunity. Diagnosis of ACD. Clinical Approach to the Patient with ACD. Usefulness of Old and New Diagnostic Tests in ACD. Therapy. Introduction of ACD Therapy. Human Recombinant Erythropoeitin. Iron. Blood Transfusions. Future Approaches: Iron and Erythropoietin. Controversies in ACD Therapy. Putative Positive Effects of ACD Correction. Putative Negative Effects of ACD Correction in Malignant and Infectious Diseases. Specific Conditions of ACD. ACD in Hematolgical Disorders and Cancer. Anemia in Cancer Patients Undergoing Surgery. ACD in Systemic Infections Including HIV. ACD in Rheumatic and Autoimmune Disorders. Anemia in Intensive Care Patients. ACD as Part of Chronic Renal Disease. ACD in Inflammatory Bowel Disease . Index