Novel Therapeutic Agents for the Treatment of Autoimmune Diseases

Vibeke Strand, David L. Scot, Lee S. Simon

• IntroductionThe Evaluation of Biological Agents, Vibeke Strand and David L. ScottCellular Targeted TherapiesAnti-CD5 Ricin A Chain Immunoconjugate Therapy in Rheumatoid Arthritis, John J. CashEarly Clinical Studies of IL-2 Fusion Toxin in Patients with Severe Rheumatoid ArthritisRecent-Onset Insulin-Dependent Diabetes Mellitus, and Psoriasis, Thasia G. Woodworth and Karen ParkerChimeric Anti-CD4 Antibody as a Potential Therapeutic Agent for Rheumatoid Arthritis, Larry W. Moreland and William J. KoopmanCD4 Monoclonal Antibody Therapy in Rheumatoid Arthritis, F. C. BreedveldThe Use of CE9.1, a Primatized Monoclonal Anti-CD4, in the Treatment of Rheumatoid Arthritis, David E. Yocum, Alan M. Solinger, and John LipaniCAMPATH-1H Therapy in Autoimmune Diseases, Richard A. Watts and John D. IsaacsCAMPATH-1H in Rheumatoid Arthritis: United States Experience, David E. Yocum and Jeffrey M. JohnstonCytokine Targeted TherapiesInterferon-Gamma in the Treatment of Rheumatoid Arthritis, Eric M. Veys, Herman Mielants, and Gust VerbruggenTumor Necrosis Factor Blockade in Rheumatoid Arthritis, Michael J. Elliott, Marc Feldmann, and Ravinder N. MainiEngineered Human Anti-Tumor Necrosis Factor-Alpha (TNFaAntibody, CDP571, in Rheumatoid Arthritis, Ernest H. S. Choy and Gabriel S. PanayiClinical Experience with Recombinant Human Interleukin-1 Receptor Type I (Rhu IL-1RI) in Patients with Rheumatoid Arthritis, Richard M. Pope, Barbara Drevlow, Jennifer Capezio, Rosa Lovis, and Alan LandayTreatment of Rheumatoid Arthritis with Soluble Tumor Necrosis Factor Receptor, Gary R. Margolies, William J. Koopman, and Larry W. MorelandAdhesion Molecule Targeted TherapiesTreatment of Rheumatoid Arthritis with a Monoclonal Antibody to Intercellular Adhesion Molecule-1, Arthur F. Kavanaugh and Peter E. LipskyPotential Antigen-Specific TherapiesT-Cell-Receptor Peptide Therapy for Multiple Sclerosis, Arthur A. Vanderbark, Dennis N. Bourdette, Ruth H. Whitham, and Halina OffnerT-Cell Receptor Peptide Vaccination Studies in Rheumatoid Arthritis, Louis W. Heck, Larry W. Moreland, and William J. KoopmanOral Tolerance for the Treatment of Autoimmune Disease, David A Hafler and Howard L. WeinerOral Tolerance, David E. TrenthamIntravenous Immunoglobulin (IVIg) in the Treatment of Autoimmune Diseases, Vibeke Strand and Martin L. LeePurine and Pyrimidine Synthesis InhibitorsInhibitors of De Novo Nucleotide Synthesis in the Treatment of Rheumatoid Arthritis, Robert I. Fox and Randall E. MorrisLeflunomide: A New Immunosuppressive Drug, David L. Scott and Vibeke StrandFuture DirectionsAn Assessment of Novel Agents in the Treatment of the Rheumatic Diseases, Vibeke Strand and Lee S. Simon