Foot and Mouth Disease

Esteban Domingo, Francisco Sobrino

"The relevance of this overview publication is apparent … . … [Chapters are] well-written … [and] effectively illustrated … . Additionally, the latest information gleamed from the increasing number of publications concerning this disease is offered … . … Virologists, molecular biologists, veterinarians, animal scientists, microbiologists, biotechnologists and prominently pharmaceutical and biotech researchers will find this updated review a significant insight into this increasingly concerning disease … . … A most timely publication that has global importance."- Vet Human Toxicol, 46 (6), Dec. 2004

• Stepping stones in foot-and-mouth research: A personal view. Genome organization, translation and replication of foot-and-mouth disease virus RNA. Foot-and-mouth disease virus proteinases. Structure of foot-and-mouth disease virus particles. Clinical signs of foot-and-mouth disease. Persistence of foot-and-mouth disease virus. Molecular aspects of foot-and-mouth disease virus virulence and host range: Role of host cell receptors and viral factors. Immunology of foot-and-mouth disease. Functional and structural aspects of the interaction of foot-and-mouth disease virus with antibodies. Quasispecies dynamics and evolution of foot-and-mouth disease virus. Modern inactivated foot-and-mouth disease (FMD) vaccines: Historical background and key elements in production and use. Foot-and-mouth disease virus peptide vaccines. Mathematical models of the epidemiology and control of foot-and-mouth disease. Natural habitats in which foot-and-mouth disease viruses are maintained. Diagnosis and control of foot-and-mouth disease. Control of foot-and-mouth disease: Role of international organizations. Overview of foot-and-mouth disease and its impact as a re-emergent viral infection.