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38 produkter
38 produkter
E-bok
PDF, Engelska, 19992 526 kr
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Are infectious diseases caused by novel entities, viruses that have rapidly evolved into more pathogenic forms, or viruses that have crossed species divides and become more virulent in their alternative host? These questions and how new diseases such as AIDS emerged have prompted renewed interest in the ways viruses originated and co-evolved with their hosts.Origin and Evolution of Viruses presents a full and clear description of general viral concepts and specific viral systems, and provides an excellent foundation to our understanding of how viruses emerged.This unique and comprehensive work is essential reading for all researchers in virology, molecular biology and related areas, as well as evolutionary biologists interested in phylogenetic approaches to molecular evolution. The reader is taken on an illumination journey--in time and concepts--from the first primitive replicons to their present-day complex viral counterparts. Apart from the obvious interest, as humans are potential hosts for these viruses, there is also a great deal of academic interest in the evolutionary aspects of this simple group of organisms, since information can be gained about the origin of stains/species and evolutionary patterns that might be applicable to higher species.The book addresses:* Nature and evolution of early replicons* DNA and RNA viruses in both plants and animals* Viral origin, mutation, and survival* Antigenic variation in influenza virus* Interplay between host evolution and DNA virus evolution* Emergence of viral-induced diseases, e.g. hepatitis, influenza and HIV
E-bok
Engelska, 20081 820 kr
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New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases.- NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution- UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups- SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
Inbunden, Engelska, 2008
1 727 kr
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New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
Häftad, Engelska, 2015
957 kr
Skickas inom 10-15 vardagar
Virus as Populations: Composition, Complexity, Dynamics, and Biological Implications explains fundamental concepts that arise from regarding viruses as complex populations when replicating in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, probability to be transmitted or response to treatment, depend on virus population numbers and in the variations of such population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, new antiviral strategies such as lethal mutagenesis, and extensions of population heterogeneity to nonviral systems are included. These main concepts of the book are framed in recent observations on general virus diversity derived from metagenomic studies, and current views on the origin of viruses and the role of viruses in the evolution of the biosphere. Features current views on the key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes
E-bok
Engelska, 20151 086 kr
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Virus as Populations: Composition, Complexity, Dynamics, and Biological Implications explains fundamental concepts that arise from regarding viruses as complex populations when replicating in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, probability to be transmitted or response to treatment, depend on virus population numbers and in the variations of such population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, new antiviral strategies such as lethal mutagenesis, and extensions of population heterogeneity to nonviral systems are included. These main concepts of the book are framed in recent observations on general virus diversity derived from metagenomic studies, and current views on the origin of viruses and the role of viruses in the evolution of the biosphere.- Features current views on the key steps in the origin of life and origins of viruses- Includes examples relating ancestral features of viruses with their current adaptive capacity- Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read- Considers quasispecies as a framework to understand virus adaptability and disease processes
Häftad, Engelska, 2019
1 166 kr
Skickas inom 10-15 vardagar
Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included.
The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere.
Features current views on key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes
E-bok
Engelska, 20191 637 kr
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Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included.The book''s main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere.- Features current views on key steps in the origin of life and origins of viruses- Includes examples relating ancestral features of viruses with their current adaptive capacity- Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read- Considers quasispecies as a framework to understand virus adaptability and disease processes
Häftad, Engelska, 2020
485 kr
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This book reviews the early evidence of genetic variability of rhabdoviruses. It describes data on the variability in the genomes of closely related virus strains and the variability that can be observed within a given virus strain.
Häftad, Engelska, 2020
485 kr
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This book describes the basic features of virus replication, and points out how these features lead into the diverse biologies and genetics of the various viruses.
E-bok
Engelska, 20195 127 kr
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The shock following the recent outbreak of foot-and-mouth disease (FMD) in the UK dispelled the notion that this disease was permanently under control and could be forgotten. FMD proved to be an endemic disease in many countries and continues to pose a major threat to animal health worldwide. The development of more effective and socially acceptabl
Inbunden, Engelska, 2018
1 974 kr
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This book analyzes the nature of polio replication complexes with respect to subcellular fractionation, responses to detergent treatments, and the viral/cellular proteins involved. It presents models for both initiation and elongation of RNA chains by the poliovirus replicase.
Inbunden, Engelska, 2017
1 903 kr
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This book describes the basic features of virus replication, and points out how these features lead into the diverse biologies and genetics of the various viruses.
Inbunden, Engelska, 2017
1 903 kr
Skickas inom 10-15 vardagar
This book reviews the early evidence of genetic variability of rhabdoviruses. It describes data on the variability in the genomes of closely related virus strains and the variability that can be observed within a given virus strain.
E-bok
PDF, Engelska, 2018942 kr
Läs direkt efter köp
This book analyzes the nature of polio replication complexes with respect to subcellular fractionation, responses to detergent treatments, and the viral/cellular proteins involved. It presents models for both initiation and elongation of RNA chains by the poliovirus replicase.
E-bok
PDF, Engelska, 2018572 kr
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This book describes the basic features of virus replication, and points out how these features lead into the diverse biologies and genetics of the various viruses.
E-bok
PDF, Engelska, 2018538 kr
Läs direkt efter köp
This book reviews the early evidence of genetic variability of rhabdoviruses. It describes data on the variability in the genomes of closely related virus strains and the variability that can be observed within a given virus strain.
E-bok
Engelska, 2018942 kr
Läs direkt efter köp
This book analyzes the nature of polio replication complexes with respect to subcellular fractionation, responses to detergent treatments, and the viral/cellular proteins involved. It presents models for both initiation and elongation of RNA chains by the poliovirus replicase.
E-bok
Engelska, 2018572 kr
Läs direkt efter köp
This book describes the basic features of virus replication, and points out how these features lead into the diverse biologies and genetics of the various viruses.
E-bok
Engelska, 2018538 kr
Läs direkt efter köp
This book reviews the early evidence of genetic variability of rhabdoviruses. It describes data on the variability in the genomes of closely related virus strains and the variability that can be observed within a given virus strain.
E-bok
PDF, Engelska, 20195 127 kr
Läs direkt efter köp
The shock following the recent outbreak of foot-and-mouth disease (FMD) in the UK dispelled the notion that this disease was permanently under control and could be forgotten. FMD proved to be an endemic disease in many countries and continues to pose a major threat to animal health worldwide. The development of more effective and socially acceptabl
Häftad, Engelska, 2017
3 010 kr
Skickas inom 3-6 vardagar
Del 439 - Current Topics in Microbiology and Immunology
Viral Fitness and Evolution
Population Dynamics and Adaptive Mechanisms
Inbunden, Engelska, 2023
1 938 kr
Skickas inom 10-15 vardagar
This book unifies general concepts of plant and animal virus evolution and covers a broad range of topics related to theoretical and experimental aspects of virus population dynamics and viral fitness.Timely topics such as viral mechanisms to cope with antiviral agents, the adaptability of the virus to new hosts, emergence of new viral phenotypes, and the connections between short- and long-term virus evolution are included. By comparing plant and animal viruses, universal mechanisms responsible for fitness variations, viral emergence and disease mechanisms are explored.Although emphasis is put on specific plant and human viral pathogens, relevant similarities and differences to other viruses are highlighted. Additionally, readers will learn more about the adaptability of coronaviruses, including the recently emerged SARS-CoV-2, the causative agent of the COVID-19 pandemic.The book is aimed at students and scientists interested in basic and applied aspectsof plant and animal virus population dynamics and evolution.
E-bok
Engelska, 20232 435 kr
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This book unifies general concepts of plant and animal virus evolution and covers a broad range of topics related to theoretical and experimental aspects of virus population dynamics and viral fitness.
Timely topics such as viral mechanisms to cope with antiviral agents, the adaptability of the virus to new hosts, emergence of new viral phenotypes, and the connections between short- and long-term virus evolution are included. By comparing plant and animal viruses, universal mechanisms responsible for fitness variations, viral emergence and disease mechanisms are explored. Although emphasis is put on specific plant and human viral pathogens, relevant similarities and differences to other viruses are highlighted. Additionally, readers will learn more about the adaptability of coronaviruses, including the recently emerged SARS-CoV-2, the causative agent of the COVID-19 pandemic.
The book is aimed at students and scientists interested in basic and applied aspectsof plant and animal virus population dynamics and evolution.
648 kr
Skickas inom 5-8 vardagar
Del 439 - Current Topics in Microbiology and Immunology
Viral Fitness and Evolution
Population Dynamics and Adaptive Mechanisms
Häftad, Engelska, 2024
1 938 kr
Skickas inom 10-15 vardagar
This book unifies general concepts of plant and animal virus evolution and covers a broad range of topics related to theoretical and experimental aspects of virus population dynamics and viral fitness.Timely topics such as viral mechanisms to cope with antiviral agents, the adaptability of the virus to new hosts, emergence of new viral phenotypes, and the connections between short- and long-term virus evolution are included. By comparing plant and animal viruses, universal mechanisms responsible for fitness variations, viral emergence and disease mechanisms are explored.Although emphasis is put on specific plant and human viral pathogens, relevant similarities and differences to other viruses are highlighted. Additionally, readers will learn more about the adaptability of coronaviruses, including the recently emerged SARS-CoV-2, the causative agent of the COVID-19 pandemic.The book is aimed at students and scientists interested in basic and applied aspectsof plant and animal virus population dynamics and evolution.
E-bok
PDF, Engelska, 20122 925 kr
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Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. It serves as an important source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.
E-bok
PDF, Engelska, 2012734 kr
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Del 60 - Progress in Drug Research
Progress in Drug Research
Häftad, Engelska, 2012
2 216 kr
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Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. It serves as an important source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.
Del 48 - Progress in Drug Research
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
Häftad, Engelska, 2013
559 kr
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Der vorliegende 48. Band der Reihe "Fortschritte der Arzneimittelfor- schung" enthalt acht Beitrage, die wiederum von anerkannten Forschern verfasst wurden. Ausserdem sind auch in diesem Band ein Stichwortver- zeichnis des Bandes sowie ein Autoren-und Titelverzeichnis und ein Titel- verzeichnis aller 48 Bande enthalten. Der Leser hat dadurch die Mog- lichkeit, nicht nur den vorliegenden Band zu konsultieren, sondern auch alle bisher erschienenen Bande quasi als enzyklopadisches N achschla- gewerk zu benutzen. Da alle Beitrage umfangreiche Literaturnachweise enthalten, ist die Moglichkeit des Zugriffes auf Original-Publikationen gegeben, was dem aktiven Forscher besonders wichtig ist und seinen eige- nen Arbeiten Impulse geben kann. Die Artikel des 48. Bandes behandeln neue Entwicklungen der Genetik, der enzymatischen Herstellung von komplexen Peptiden und bringen die neuesten Erkenntnisse der Apoptose unserem Verstandnis naher.Immun- therapie bei Hirnerkrankungen und psychischen Storungen, der Einsatz vonNaturproduktenzur Vorbeugung von Krebserkrankungen, das beun- ruhigende Anwachsen der Arzneimittelresistenz, die Mannigfaltigkeit der Dopamin-Rezeptor-Wirkung und die faszinierende Darstellung einer grosseren Gruppe von neuartigen Nukleosiden als Arzneimittel runden den vorliegenden Band der "Fortschritte der Arzneimittelforschung" ab und bieten dem Leser viel Neuartiges und Interessantes.
Del 392 - Current Topics in Microbiology and Immunology
Quasispecies: From Theory to Experimental Systems
Inbunden, Engelska, 2016
1 664 kr
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This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.