This volume provides a state-of-the-art survey of developments in the field of NK cell-cancer cell interactions, activation, and oncolytic signaling. Specific topics discussed include NK cell receptors and adhesion molecules, signal transduction and activation, and mechanisms of cytotoxicity. The book will be an excellent learning tool and reference resource for scientists, clinicians, and students.
NK CELL RECEPTORS AND ADHESION MOLECULES. Molecular Cloning of Human and Murine Natural Killer Cell Tumor Recognition Proteins (Stephen K. Anderson). Structure and Function of the CD16:z:g NK Receptor Complex (Paul Anderson and Eric Viver). Molecular Characterization of a Novel NK Cell Signal Transduction Molecule: NKR-P1 (Roberto Giorda, Edward P. Weisberg, Edward P. Tagge, and Massimo M. Trucco). Modulation of Function-Associated Molecules on Natural Killer Cells Alters Recognition and Cytotoxicity (David T. Harris, Liliana Jaso-Friedmann, and Donald L. Evans). Bright Phenotype of Adhesion Molecules on Lymphocytes with High Oncolytic Function (Eva Lotzová and C.A. Savary). Human NK Cell Adhesion Molecules (CAMs) (Daniela Zarcone, Giannamaria Cerruti, Claudya Tenca, Giuseppe Arancia, Walter Malorni, Francesca Iosi, and Carlo E. Grossi). Fibronectin Receptors on NK Cells (Angela Santoni, Angela Gismondi, Gabriella Palmieri, Stefania Morrone, Fabrizio Mainiero, Giorgio Santoni, Martin J. Humphries, Mario Piccoli, and Luigi Frati). Function of the Fibronectin Receptor on Human NK Cells (Eero Saksela, Kristina Somersalo, Tamas Magyarlaki, and Ismo Virtanen). Interaction of Human Natural Killer Cells with the Vascular Endothelium: Characterization of Their Migratory Ability and Adhesive Molecules (Paola Allavena, GianCarlo Bianchi, Carla Paganin, Ines Martin-Padura, Barbara Bottazzi, Miranda Apiranthitou Drogari, Mirella Gaboli, PierCarlo Marchisio, and Alberto Mantovani). SIGNAL TRANSDUCTION AND ACTIVATION. Signal Transduction Mechanisms in NK Cell Cytotoxicity (Zacharie Brahmi). Signal Transduction During NK Cell Activation (Paul J. Leibson). Shared Structural and Functional Motifs for Signal Transduction in T Lymphocytes and Natural Killer Cells (Ian C. S. Kennedy, John R. Ortaldo, and John J. O'Shea). Characterization and Functional Significance of NKR-P1 (3.2.3 Antigen): A Novel Triggering Molecule (William H. Chambers, Albert B. DeLeo, Nikola L. Vujanovic, Ronald
