Medicinal Applications of Coordination Chemistry

Honorary Visiting Professor in Radiochemistry, University of Manchester

The section on platinum, like the others, is in general well illustrated with line diagrams of chemical structures, and gives a good coverage of new developments, such as active trans complexes and potent di- and tri-Pt anticancer complexes.This book will serve a useful role in teaching inorganic chemistry to both undergraduate and postgraduate students. The topic helps to 'bring inorganic chemistry to life' and in my experience does arouse their curiosity at all levels. It will be a useful addition to libraries.

• Preface;Chapter 1: INTRODUCTION;1.1: METALS IN MEDICINE - A HISTORICAL PERSPECTIVE;1.2: METALS AND HUMAN BIOCHEMISTRY;1.3: METALLOPHARMACEUTICALS;1.4: THE SPECIAL PROPERTIES OF METALS;Chapter 2: THE CHEMISTRY OF METALS IN A NUTSHELL;2.1: THE STRUCTURE OF MATERIALS;2.2: THE STRUCTURES AND PROPERTIES OF ATOMS;2.3: THE FORMATION OF COMPOUNDS;2.4: THE CHEMISTRY OF METALS - AN OVERVIEW;2.5: BONDING IN METAL COMPLEXES;2.6: THE MAGNETISM AND SPECTROSCOPY OF METAL COMPLEXES;2.7: THE ENERGETICS OF METAL COMPLEX FORMATION;2.8: REACTIONS AT METAL CENTRES;2.9: REDOX POTENTIALS;2.10: CONCLUSIONS;Chapter 3: DIAGNOSTIC MEDICINE;3.1: INTRODUCTION;3.2: ANATOMICAL IMAGING;3.3: FUNCTIONAL IMAGING;3.4: In vitro APPLICATIONS;Chapter 4: THERAPEUTIC MEDICINE;4.1: THE USE OF METAL COMPOUNDS IN THERAPY;4.2: CHELATION THERAPY;4.3: CANCER THERAPY;4.4: RHEUMATOID ARTHRITIS;4.5: DIABETES;4.6: CARDIOVASCULAR SYSTEM;4.7: THERAPEUTIC RADIOPHARMACEUTICALS;Chapter 5: METALLOPHARMACEUTICAL DESIGN;5.1: INTRODUCTION;5.2: STRUCTURE ACTIVITY RELATIONSHIPS;5.3: FUTURE DIRECTIONS