The Editors Professor Diana Anderson currently holds the Established Chair at the Department of Biomedical Sciences at the University of Bradford, UK and is Research Co-ordinator for the Department. Professor Anderson joined BIBRA International in 1981 and in 1992, she became Senior Associate and Co-ordinator of External Affairs at BIBRA. She has over 300 publications, has edited/authored 6 books and guest-edited 9 special issues of 4 international journals. She has is Series Editor of books Issues in Toxicology for the Royal Society of Chemistry. As an active Committee member, she has been Vice-President of the Institute of Biology and is Chair of the Scientific Committee of the International Association of Environmental Mutagen Societies and is a consultant for many international organisations, such as the WHO, NATO, TWAS, UNIDO and the OECD. Dr Martin Brinkworth

• Part One: Introductory Scientific Presentations;Foreword;Chapter 1: Epigenetic Transgenerational Actions Of Endocrine Disruptors Through The Male Germ-Line;Part Two: Heritable Effects in Humans;Chapter 2: Reproductive Outcomes Among Men Treated For Cancer;Chapter 3: Cancer in siblings of children with cancer in the Nordic countries - A population-based cohort study: Paediatric cancer: an indicator of familial cancer risk?;Chapter 4: What Harms The Developing Male Reproductive System?;Chapter 5: Links Between Paternal Smoking and Childhood Cancer;Chapter 6: Metal Effects On The X:Y Ratio In Human Sperm;Chapter 7: Use Of The Sperm Chromatin Structure Assay (Scsa®) As A Diagnostic Tool In The Human Infertility Clinic;Chapter 8: Safety of Sperm For Use In ICSI;Part Three : Animal Models ;Chapter 9 : Male-Mediated F1 Effects In Mice Exposed To Di(2-Ethylhexyl)Phthalate (DEHP);Chapter 10: Prevention of Adverse Effects of Cancer Treatment on the Germline;Chapter 11: Molecular Changes In Sperm And Early Embryos After Paternal Exposure To A Chemotherapeutic Agent;Chapter 12: Transmissible Genetic Risk Causing Tumours in Mice and Humans;Chapter 13: Heritable Effects on DNA Damage Following Paternal F0 Germline Irradiation;Chapter 14: Influence of DNA Methylation and Genomic Imprinting in the Male Germ Line on Pregnancy Outcome;Chapter 15: Information Content Of Ejaculate Spermatozoa And Its Potential Utility In Toxicology And Infertility Based Research Programmes;Part Four: Germline Mutagenesis;Chapter 16: Origin Of Paternal Mutations;Chapter 17: Redox Regulation Of DNA Damage In The Male Germ Line;Chapter 18: Advances In The Direct Measurements Of Partial Chromosomal Duplication, Deletions And Breaks In Human And Murine Sperm By Sperm FISH;Chapter 19: Radiation-induced Transgenerational Instability In Mice;Chapter 20: New Genetic Information Generated By Endogenous Reverse Transcription In Sperm Cells;Chapter 21: Sperm Abnormalities in Exposed Humans;Chapter 22: OESTROGENIC COMPOUNDS AND OXIDATIVE STRESS;Chapter 23: DNA Repair Capacities In Testicular Cells Of Rodents And Man;Chapter 24: Closing Panel Discussion;Subject Index

The Editors Professor Diana Anderson currently holds the Established Chair at the Department of Biomedical Sciences at the University of Bradford, UK and is Research Co-ordinator for the Department. Professor Anderson joined BIBRA International in 1981 and in 1992, she became Senior Associate and Co-ordinator of External Affairs at BIBRA. She has over 300 publications, has edited/authored 6 books and guest-edited 9 special issues of 4 international journals. She has is Series Editor of books Issues in Toxicology for the Royal Society of Chemistry. As an active Committee member, she has been Vice-President of the Institute of Biology and is Chair of the Scientific Committee of the International Association of Environmental Mutagen Societies and is a consultant for many international organisations, such as the WHO, NATO, TWAS, UNIDO and the OECD. Dr Martin Brinkworth

• Part One: Introductory Scientific Presentations;Foreword;Chapter 1: Epigenetic Transgenerational Actions Of Endocrine Disruptors Through The Male Germ-Line;Part Two: Heritable Effects in Humans;Chapter 2: Reproductive Outcomes Among Men Treated For Cancer;Chapter 3: Cancer in siblings of children with cancer in the Nordic countries - A population-based cohort study: Paediatric cancer: an indicator of familial cancer risk?;Chapter 4: What Harms The Developing Male Reproductive System?;Chapter 5: Links Between Paternal Smoking and Childhood Cancer;Chapter 6: Metal Effects On The X:Y Ratio In Human Sperm;Chapter 7: Use Of The Sperm Chromatin Structure Assay (Scsa®) As A Diagnostic Tool In The Human Infertility Clinic;Chapter 8: Safety of Sperm For Use In ICSI;Part Three : Animal Models ;Chapter 9 : Male-Mediated F1 Effects In Mice Exposed To Di(2-Ethylhexyl)Phthalate (DEHP);Chapter 10: Prevention of Adverse Effects of Cancer Treatment on the Germline;Chapter 11: Molecular Changes In Sperm And Early Embryos After Paternal Exposure To A Chemotherapeutic Agent;Chapter 12: Transmissible Genetic Risk Causing Tumours in Mice and Humans;Chapter 13: Heritable Effects on DNA Damage Following Paternal F0 Germline Irradiation;Chapter 14: Influence of DNA Methylation and Genomic Imprinting in the Male Germ Line on Pregnancy Outcome;Chapter 15: Information Content Of Ejaculate Spermatozoa And Its Potential Utility In Toxicology And Infertility Based Research Programmes;Part Four: Germline Mutagenesis;Chapter 16: Origin Of Paternal Mutations;Chapter 17: Redox Regulation Of DNA Damage In The Male Germ Line;Chapter 18: Advances In The Direct Measurements Of Partial Chromosomal Duplication, Deletions And Breaks In Human And Murine Sperm By Sperm FISH;Chapter 19: Radiation-induced Transgenerational Instability In Mice;Chapter 20: New Genetic Information Generated By Endogenous Reverse Transcription In Sperm Cells;Chapter 21: Sperm Abnormalities in Exposed Humans;Chapter 22: OESTROGENIC COMPOUNDS AND OXIDATIVE STRESS;Chapter 23: DNA Repair Capacities In Testicular Cells Of Rodents And Man;Chapter 24: Closing Panel Discussion;Subject Index

The Editors Professor Diana Anderson currently holds the Established Chair at the Department of Biomedical Sciences at the University of Bradford, UK and is Research Co-ordinator for the Department. Professor Anderson joined BIBRA International in 1981 and in 1992, she became Senior Associate and Co-ordinator of External Affairs at BIBRA. She has over 300 publications, has edited/authored 6 books and guest-edited 9 special issues of 4 international journals. She has is Series Editor of books Issues in Toxicology for the Royal Society of Chemistry. As an active Committee member, she has been Vice-President of the Institute of Biology and is Chair of the Scientific Committee of the International Association of Environmental Mutagen Societies and is a consultant for many international organisations, such as the WHO, NATO, TWAS, UNIDO and the OECD. Dr Martin Brinkworth

• Part One: Introductory Scientific Presentations;Foreword;Chapter 1: Epigenetic Transgenerational Actions Of Endocrine Disruptors Through The Male Germ-Line;Part Two: Heritable Effects in Humans;Chapter 2: Reproductive Outcomes Among Men Treated For Cancer;Chapter 3: Cancer in siblings of children with cancer in the Nordic countries - A population-based cohort study: Paediatric cancer: an indicator of familial cancer risk?;Chapter 4: What Harms The Developing Male Reproductive System?;Chapter 5: Links Between Paternal Smoking and Childhood Cancer;Chapter 6: Metal Effects On The X:Y Ratio In Human Sperm;Chapter 7: Use Of The Sperm Chromatin Structure Assay (Scsa®) As A Diagnostic Tool In The Human Infertility Clinic;Chapter 8: Safety of Sperm For Use In ICSI;Part Three : Animal Models ;Chapter 9 : Male-Mediated F1 Effects In Mice Exposed To Di(2-Ethylhexyl)Phthalate (DEHP);Chapter 10: Prevention of Adverse Effects of Cancer Treatment on the Germline;Chapter 11: Molecular Changes In Sperm And Early Embryos After Paternal Exposure To A Chemotherapeutic Agent;Chapter 12: Transmissible Genetic Risk Causing Tumours in Mice and Humans;Chapter 13: Heritable Effects on DNA Damage Following Paternal F0 Germline Irradiation;Chapter 14: Influence of DNA Methylation and Genomic Imprinting in the Male Germ Line on Pregnancy Outcome;Chapter 15: Information Content Of Ejaculate Spermatozoa And Its Potential Utility In Toxicology And Infertility Based Research Programmes;Part Four: Germline Mutagenesis;Chapter 16: Origin Of Paternal Mutations;Chapter 17: Redox Regulation Of DNA Damage In The Male Germ Line;Chapter 18: Advances In The Direct Measurements Of Partial Chromosomal Duplication, Deletions And Breaks In Human And Murine Sperm By Sperm FISH;Chapter 19: Radiation-induced Transgenerational Instability In Mice;Chapter 20: New Genetic Information Generated By Endogenous Reverse Transcription In Sperm Cells;Chapter 21: Sperm Abnormalities in Exposed Humans;Chapter 22: OESTROGENIC COMPOUNDS AND OXIDATIVE STRESS;Chapter 23: DNA Repair Capacities In Testicular Cells Of Rodents And Man;Chapter 24: Closing Panel Discussion;Subject Index