Protocols for Oligonucleotides and Analogs

Synthesis and Properties

AvSudhir Agrawal

Inbunden, Engelska, 1993

Del i serien Methods in Molecular Biology

2 111 kr

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Beskrivning

Leading researchers summarize and describe their experience and techniques for synthesizing oligonucleotides and their analogs. The protocols presented cover all DNA analogs that have been studied to date and constitute the single most extensive source of knowledge about DNA chemistry available.

Produktinformation

Utgivningsdatum:1993-08-31
Mått:155 x 235 x 38 mm
Vikt:896 g
Format:Inbunden
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:502
Upplaga:1993
Förlag:Humana Press Inc.
ISBN:9780896032811

Utforska kategorier

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Biologi inom Naturvetenskap och teknik

Recensioner i media

...comprehensive and authoritative definitely required reading for the would-be oligonucleotide chemist and for those involved in biological applications of oligonucleotides... - Journal of Pharmacy and Pharmacology

Innehållsförteckning

A Brief History of Oligonucleotide Synthesis.- Oligonucleotide Synthesis.- Oligodeoxyribonucleotides Synthesis.- Oligodeoxynucleotide Synthesis.- Oligoribonucleotide Synthesis.- Synthesis of 2?-O-Alkyloligoribonucleotides.- An Improved Method for the Synthesis and Deprotection of Methylphosphonate Oligonucleotides.- Oligonucleoside Phosphorothioates.- Synthesis and Purification of Phosphorodithioate DNA.- Oligodeoxyribonucleotide Phosphotriesters.- Oligonucleoside Boranophosphate (Borane Phosphonate).- Oligonucleotide Phosphorofluoridates and Fluoridites.- ?-Oligodeoxynucleotides.- Stereospecific Synthesis of P-Chiral Analogs of Oligonucleotides.- Oligonucleotide Analogs with Dimethylenesulfide, -sulfoxide, and -sulfone Groups Replacing Phosphodiester Linkages.- Oligonucleotide Analogs Containing Dephospho-Internucleoside Linkages.- Scale-Up of Oligonucleotide Synthesis.- Large-Scale Oligonucleotide Synthesis Using the Solid-Phase Approach.- Solid-Phase Supports for Oligonucleotide Synthesis.