"The book presents a broad overview of the field at a level that is easy to understand...provides an advanced understanding of the current state of the field and leaves the reader receptive to new concepts and therapies for allergic disease that will soon be forthcoming"-Dale T. Umetsu, MD, PhD, review in the April 29, 1999 issue of The New England Journal of Medicine "...an excellent book on allergy and allergic diseases...a carefully thought-out whole, starting with IgE mechanisms, environmental allergens, and the new "jungle hypothesis" of atopic disorders beginning in early childhood. The book then proceeds to cellular and molecular aspects of inflammation, highlighting the key points of the pathogenesis of allergy in different organs, and ending with the essentials of treatment." - Allergy "The book certainly has the five main features described in the presentation: it is written by leading authorities in allergy research...it provides an updated comprehensive survey of the mechanisms of allergic diseases; it illustrates the cellular and molecular bases of allergy and asthma; it emphasizes pathogenesis and the relevance of mechanisms to clinical expression; it includes useful information on therapeutics and possibilities for drug discovery." - EACCI

• I. Epidemiology/IgE.- 1 Molecular Mechanisms of Isotype Switching to IgE.- 2 Cytokines and IgE Regulation.- 3 Environmental Allergens.- 4 Ontogeny of Allergy.- II. Inflammation: Cellular Aspects.- 5 The Role of the Bone Marrow in Allergic Disease.- 6 The Role of Mast Cells in Inflammation and Homeostatis.- 7 Human Langerhans Cells.- 8 Eosinophils.- 9 Role of Basophils in Allergic Reactions.- 10 Neurogenic Inflammation in Allergic Disease.- 11 Inflammation: Thl/Th2 Cells.- 12 T-Cells in the Pathogenesis of Asthma and Allergic Diseases.- 13 Role of CD8+ T-Cells in the Regulation of Immunoglobulin E.- 14 Airway Wall Structure.- 15 Epithelium.- III. Inflammation: Molecular Aspects.- 16 Proinflammatory Cytokines in Allergic Disease.- 17 Hemopoietic Cytokines: Function, Receptors, and Signal Transduction.- 18 Adhesion Receptors in Allergic Disease.- 19 Cell/Cytokine Interactions.- 20 Signaling in Mast Cells.- 21 Signaling in Human Basophils.- 22 Eosinophil Signal Transduction.- IV. Pathogenesis.- 23 Pathogenesis of Allergic Rhinitis.- 24 Pathogenic Mechanisms of Urticaria.- 25 Atopic Eczema.- 26 Pathogenesis of Asthma.- 27 Pathogenesis of Allergic Conjunctivitis.- V. Therapeutics.- 28 Glucocorticoids (Corticosteroids).- 29 Beta-Agonists.- 30 Sodium Cromoglycate and Nedocromil Sodium.- 31 Airway Remodeling and Repair.

"The book presents a broad overview of the field at a level that is easy to understand...provides an advanced understanding of the current state of the field and leaves the reader receptive to new concepts and therapies for allergic disease that will soon be forthcoming"-Dale T. Umetsu, MD, PhD, review in the April 29, 1999 issue of The New England Journal of Medicine "...an excellent book on allergy and allergic diseases...a carefully thought-out whole, starting with IgE mechanisms, environmental allergens, and the new "jungle hypothesis" of atopic disorders beginning in early childhood. The book then proceeds to cellular and molecular aspects of inflammation, highlighting the key points of the pathogenesis of allergy in different organs, and ending with the essentials of treatment." - Allergy "The book certainly has the five main features described in the presentation: it is written by leading authorities in allergy research...it provides an updated comprehensive survey of the mechanisms of allergic diseases; it illustrates the cellular and molecular bases of allergy and asthma; it emphasizes pathogenesis and the relevance of mechanisms to clinical expression; it includes useful information on therapeutics and possibilities for drug discovery." - EACCI

• I. Epidemiology/IgE.- 1 Molecular Mechanisms of Isotype Switching to IgE.- 2 Cytokines and IgE Regulation.- 3 Environmental Allergens.- 4 Ontogeny of Allergy.- II. Inflammation: Cellular Aspects.- 5 The Role of the Bone Marrow in Allergic Disease.- 6 The Role of Mast Cells in Inflammation and Homeostatis.- 7 Human Langerhans Cells.- 8 Eosinophils.- 9 Role of Basophils in Allergic Reactions.- 10 Neurogenic Inflammation in Allergic Disease.- 11 Inflammation: Thl/Th2 Cells.- 12 T-Cells in the Pathogenesis of Asthma and Allergic Diseases.- 13 Role of CD8+ T-Cells in the Regulation of Immunoglobulin E.- 14 Airway Wall Structure.- 15 Epithelium.- III. Inflammation: Molecular Aspects.- 16 Proinflammatory Cytokines in Allergic Disease.- 17 Hemopoietic Cytokines: Function, Receptors, and Signal Transduction.- 18 Adhesion Receptors in Allergic Disease.- 19 Cell/Cytokine Interactions.- 20 Signaling in Mast Cells.- 21 Signaling in Human Basophils.- 22 Eosinophil Signal Transduction.- IV. Pathogenesis.- 23 Pathogenesis of Allergic Rhinitis.- 24 Pathogenic Mechanisms of Urticaria.- 25 Atopic Eczema.- 26 Pathogenesis of Asthma.- 27 Pathogenesis of Allergic Conjunctivitis.- V. Therapeutics.- 28 Glucocorticoids (Corticosteroids).- 29 Beta-Agonists.- 30 Sodium Cromoglycate and Nedocromil Sodium.- 31 Airway Remodeling and Repair.