Adrenal Disorders

"This is an up-to-date book on the adrenal gland encompassing the latest information on the physiology and diseases...This book, authored by the experts in the field, is written in a clear manner and despite the multiple authors, is quite uniform in its style, a credit to the editors. It is an important book to be read by clinical endocrinologists and researchers in the field of adrenal hormones...This is a unique book in the excellent series Contemporary Endocrinology. This should be on the bookshelf, or at least available, to endocrinologists and endocrine fellows in training. It will clarify many issues in the evaluation and treatment of patients with adrenal disorders." -Doody's Health Sciences Book Review Journal "...The book includes new insights into a number of clinical conditions, with surprising results. Margioris and Chrousos have skillfully woven together the physiological background and clinical practice to produce a collection that brings clinicians up to date regarding the pathophysiology of adrenal disorders and uses physiology to point toward patterns of disease that, to date, have remained unexplained...there is a wealth of carefully thought-out approaches to clinical problems. The result, in many of the chapters, is a personal approach that avoids the anecdotal and is based on sound evidence and tested experience...The clinical content is well illustrated with clinical management pathways, which greatly enhance the text...The editors have gone one step further in promoting evidence-based practice by soliciting chapters from research groups with a large number of patients..."-The New England journal of Medicine "Clearly and concisely written with many references, it is recommended for pediatric and adult endocrinologists as well as gynecologists and endocrinologists." -Journal of Pediatric Endocrinology and Metabolism

• Part I. The Adrenal Gland: Physiology Ontogeny of the Hypothalamo-Pituitary-Adrenal AxisMichel Grino, Nadia Dakine, Odile Paulmyer-Lacroix, and Charles Oliver Adrenal Organogenesis and Steroidogenesis: Role of Nuclear Nuclear Receptor Steroidogenic Factor-1, DAX-1, and Estrogen ReceptorMeera S. Ramayya Reappraisal of Adrenal Zonation Theories Based on the Differential Regulation of Apoptosis, G. W. Wolkersdörfer and Stefan R. Bornstein Pharmacology of Glucocorticoids: An OverviewAchille Gravanis and Andrew N. Margioris Glucocorticoid Catabolism and the 11_-Hydroxysteroid Dehydrogenase SystemJonathan R. Seckl Androgens of Adrenal OriginGeorge Mastorakos and Anthony G. Doufas Structure, Function, and Regulated Expression of the Steroidogenic Acute Regulatory (StAR) Protein: Molecular Insights into the Acute Seroidogenic Response of the Adrenals and Gonads to Trophic StimulationCaleb B. Kallen, Futoshi Arakane, Teruo Sugawara, Marianthi Kiriakidou, Staci E. Pollack, Hidemichi Watari, Lane K. Christenson, Michiko Watari, and Jerome F. Strauss III Regulation of Adrenocortical Function by the Sympathoadrenal System: Physiology and PathologyMonika Ehrhart-Bornstein and Stefan R. Bornstein Interleukin (IL)-1 Family of Cytokines and Corticotropin-Releasing Hormone (CRH) in the Adrenal GlandAndrew N. Margioris, Erene Dermitzaki, Maria Venihaki, and Achille Gravanis Part II. The Adrenal Gland: Pathophysiology Overview of Hyper- and HypocortisolismW.W. de Herder and S.W.J. Lambert ACTH Resistance, Constantine Tsigos. Syndromes of Ectopic ACTH Secretion: Recent Pathophysiological AspectsYves de Keyzer, Marie Laure Raffin-Sanson, Agnés Picon, and Xavier Bertagna Clinical Presentations and Diagnosis of Cushing's SyndromeAndrew N. Margioris and George P.Chrousos The Desmopressin Test: A New Tool in the Functional Evaluation of the Pituitary-Adrenal Axis Patients with Cushing's SyndromeS. Tsagarakis and N. Thalassinos PseudoCushing SyndromesTheodore Friedman Adrenocortical Tumors and OncogenesMartin Reincke Management of Adrenal CancerDavid E. Schteingart and Dominic Homan Adrenal IncidentalomasBruno Allolio Congenital Adrenal Hyperplasia: 21-Hydroylase DeficiencyMaria I. New Steroid 11_-Hydroxylase DeficiencyPerrin C. White Micronodular Adrenal Disease and the Syndrome of Myxomas, Spotty Skin Pigmentation, and Endocrine OveractivityConstantine A. Stratakis Congenital Lipoid Adrenal HyperplasiaWalter L. Miller Congenital Adrenal HypoplasiaMichael Peter and Wolfgang G. Sippell The HPA Axis and HIV InfectionDaniel S. Donovan, Jr. and Robert G. Dluhy Hypothalamic-Pituitary-Adrenal Axis and ObesityPer Björntorp and Roland Rosmond Aldosterone Synthase DeficiencyMichael Peter and Wolfgang G. Sippel Mineralocorticoid Excess SyndromesRichard D. Gordon Pheochromocytoma: Progress in Diagnosis, Therapy, and GeneticsKarel Pacak, George P. Chrousos, Christian A. Koch, Jacques W. M. Lenders, and Graeme Eisenhofer