"The editor states the goal is to offer a comprehensive picture of recent advances made in the signaling field as it relates to neuronal and cerebral function... The editor and the contributors accomplished the goal remarkably well. The chapters are arranged so that clinical and laboratory investigations on depression, bipolar disorder, and drug dependence follow more basic research on memory, apoptosis, and degeneration. Each chapter is extremely well referenced, making this a valuable reference source. Multiple black-and-white illustrations, drawings, and microphotographs enhance the text quality...This new volume in the series Contemporary Neuroscience may serve as an excellent overview of current knowledge in the field of cerebral signaling and transduction."-Doody's Health Science Book Review Journal "The quality of each of the chapters of this book is outstanding and will provide valuable information for a variety of neuroscientists."- Journal of Molecular Neuroscience

• I. Introduction.- 1 • From First to Fourth Messengers in the Brain: An Overview.- II. Memory.- 2 • Cellular and Molecular Mechanisms of Learning and Memory.- 3 • Signal Transduction Pathways in Well-Defined Models of Learning and Memory: Drosophila and Honeybee.- 4 • Protein Kinase C Signaling in Learning and Memory.- III. Neurodegeneration and Apoptosis.- 5 • Neurotransmitter Receptor—G-Protein-Mediated Signal Transduction in Alzheimer’s Disease.- 6 • The NO Signaling Pathway in the Brain: Neural Injury, Neurological Disorders, and Aggression.- 7 • Cellular Signaling Pathways in Neuronal Apoptosis: Role in Neurodegeneration and Alzheimer’s Disease.- 8 • The Role of Second Messengers in Neurodegeneration.- IV. Depression.- 9 • Molecular and Cellular Determinants of Stress and Antidepressant Treatment.- 10 • Long-Term Bidirectional Hormonal and Neuroplastic Responses to Stress: Implications for the Treatment of Depression.- 11 • Signal Transduction Abnormalities in Bipolar Affective Disorder.- V. Drug Dependence.- 12 • Messengers in Opioid Dependence: Gene Disruption Studies.- 13 • The 5-HT1B Knockout Mouse: An Animal Model of Vulnerability to Drugs of Abuse.- 14 • Regulation of Dopamine Transporter by Phosphorylation and Impact on Cocaine Action.- 15 • Dopamine Transporter mRNA in Human Brain: Distribution and Regulatory Effects in Autopsy Studies of Cocaine Abusers.

"The editor states the goal is to offer a comprehensive picture of recent advances made in the signaling field as it relates to neuronal and cerebral function... The editor and the contributors accomplished the goal remarkably well. The chapters are arranged so that clinical and laboratory investigations on depression, bipolar disorder, and drug dependence follow more basic research on memory, apoptosis, and degeneration. Each chapter is extremely well referenced, making this a valuable reference source. Multiple black-and-white illustrations, drawings, and microphotographs enhance the text quality...This new volume in the series Contemporary Neuroscience may serve as an excellent overview of current knowledge in the field of cerebral signaling and transduction."-Doody's Health Science Book Review Journal "The quality of each of the chapters of this book is outstanding and will provide valuable information for a variety of neuroscientists."- Journal of Molecular Neuroscience

• I. Introduction.- 1 • From First to Fourth Messengers in the Brain: An Overview.- II. Memory.- 2 • Cellular and Molecular Mechanisms of Learning and Memory.- 3 • Signal Transduction Pathways in Well-Defined Models of Learning and Memory: Drosophila and Honeybee.- 4 • Protein Kinase C Signaling in Learning and Memory.- III. Neurodegeneration and Apoptosis.- 5 • Neurotransmitter Receptor—G-Protein-Mediated Signal Transduction in Alzheimer’s Disease.- 6 • The NO Signaling Pathway in the Brain: Neural Injury, Neurological Disorders, and Aggression.- 7 • Cellular Signaling Pathways in Neuronal Apoptosis: Role in Neurodegeneration and Alzheimer’s Disease.- 8 • The Role of Second Messengers in Neurodegeneration.- IV. Depression.- 9 • Molecular and Cellular Determinants of Stress and Antidepressant Treatment.- 10 • Long-Term Bidirectional Hormonal and Neuroplastic Responses to Stress: Implications for the Treatment of Depression.- 11 • Signal Transduction Abnormalities in Bipolar Affective Disorder.- V. Drug Dependence.- 12 • Messengers in Opioid Dependence: Gene Disruption Studies.- 13 • The 5-HT1B Knockout Mouse: An Animal Model of Vulnerability to Drugs of Abuse.- 14 • Regulation of Dopamine Transporter by Phosphorylation and Impact on Cocaine Action.- 15 • Dopamine Transporter mRNA in Human Brain: Distribution and Regulatory Effects in Autopsy Studies of Cocaine Abusers.

"The editor states the goal is to offer a comprehensive picture of recent advances made in the signaling field as it relates to neuronal and cerebral function... The editor and the contributors accomplished the goal remarkably well. The chapters are arranged so that clinical and laboratory investigations on depression, bipolar disorder, and drug dependence follow more basic research on memory, apoptosis, and degeneration. Each chapter is extremely well referenced, making this a valuable reference source. Multiple black-and-white illustrations, drawings, and microphotographs enhance the text quality...This new volume in the series Contemporary Neuroscience may serve as an excellent overview of current knowledge in the field of cerebral signaling and transduction."-Doody's Health Science Book Review Journal "The quality of each of the chapters of this book is outstanding and will provide valuable information for a variety of neuroscientists."- Journal of Molecular Neuroscience

• I. Introduction.- 1 • From First to Fourth Messengers in the Brain: An Overview.- II. Memory.- 2 • Cellular and Molecular Mechanisms of Learning and Memory.- 3 • Signal Transduction Pathways in Well-Defined Models of Learning and Memory: Drosophila and Honeybee.- 4 • Protein Kinase C Signaling in Learning and Memory.- III. Neurodegeneration and Apoptosis.- 5 • Neurotransmitter Receptor—G-Protein-Mediated Signal Transduction in Alzheimer’s Disease.- 6 • The NO Signaling Pathway in the Brain: Neural Injury, Neurological Disorders, and Aggression.- 7 • Cellular Signaling Pathways in Neuronal Apoptosis: Role in Neurodegeneration and Alzheimer’s Disease.- 8 • The Role of Second Messengers in Neurodegeneration.- IV. Depression.- 9 • Molecular and Cellular Determinants of Stress and Antidepressant Treatment.- 10 • Long-Term Bidirectional Hormonal and Neuroplastic Responses to Stress: Implications for the Treatment of Depression.- 11 • Signal Transduction Abnormalities in Bipolar Affective Disorder.- V. Drug Dependence.- 12 • Messengers in Opioid Dependence: Gene Disruption Studies.- 13 • The 5-HT1B Knockout Mouse: An Animal Model of Vulnerability to Drugs of Abuse.- 14 • Regulation of Dopamine Transporter by Phosphorylation and Impact on Cocaine Action.- 15 • Dopamine Transporter mRNA in Human Brain: Distribution and Regulatory Effects in Autopsy Studies of Cocaine Abusers.