Bokus
John A. Hickman, Caroline Dive - Apoptosis and Cancer Chemotherapy, Inbunden

Inbunden, Engelska, 1999

Apoptosis and Cancer Chemotherapy

Av John A. Hickman, Caroline Dive

Del i serien Cancer Drug Discovery and Development

1663 kr

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Beskrivning
This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agents to the mechanisms coupling DNA damage to the activation pathway of apoptosis. It reviews the profusion of new signaling, modulating, and effector molecules now implicated in apoptosis and whether other routes to "programmed" cell death may exist. Also addressed are the nature of the molecules that will either constitute targets for future drugs or influence the efficacy of current therapies, as well as mechanistic questions on the control of apoptosis. By focusing on essential questions and critically summarizing the overwhelming tide of recent research results, Apoptosis and Cancer Chemotherapy illuminates not only the potential targets for tumor therapy, but beyond that, potential control points for cancer and such diverse diseases as viral infection, neurodegenerative disorders, and stroke. This collection of cutting-edge reviews by established leaders in the field critically summarizes the recent discoveries concerning apoptosis, cell suicide.The book looks forward to the time when such cell death can be controlled to treat cancer and a host of other diseases as diverse as viral infection, neurodegenerative disorders, and stroke.
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"This book provides a balanced view on the current knowledge on the relation between apoptosis and chemotherapy...The greatest merit of the book is to gather the different opinions about the relevance of apoptosis in chemosensitivity...Another positive aspect of this book is the effort made in having a relatively recent update presentation in most chapters, what is quite a remarkable achievement in a field where new molecules and pathways are continuously being discovered and described. Furthermore, the main concepts are discussed throughout this book in a balanced fashion, combining solid literature with some speculation, sometimes rather provocative as well...a book that pays off, since it provides an informative journey through a complex and interesting field. This book should be recommended not only for medical oncologists interested in molecular and mechanistic discussion about chemosensitivity, but also for basic scientists working in the field of drug-induced apoptosis."-Annals of Oncology "This book of 21 chapters is a clinically relevant assessment of the chemotherapeutic significance of apoptosis in cancer treatment...the chapters are well written, relatively up to date and reasonably well illustrated."-Cell Biology International "This book is of value to many scientists as a current reference to a complicated field. It also provides a balanced view of the field and warns investigators that complexity is the norm and over-simplification is a laboratory phenomenon."-Oncology "...This book is an excellent critical summary of where the field is today...This is an excellent book with up to date references useful to graduate students, clinicians and researchers who, in a few hours reading would gain a broad overview of the current field."-Today's Life Science "This volume represents the most comprehensive work devoted to the subject, and the editors have done an outstanding job of recruiting some of the most prominent researchers in the field...the book is an outstanding resource and should be extremely valuable to all investigators interested in cancer research."-Quarterly Review of Biology

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