Cancer Drug Discovery and Development – serie
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191 produkter
Cancer Therapeutics
Experimental and Clinical Agents
Inbunden, 1996
2247 kr
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This comprehensive review of existing and potential anticancer drugs and therapies by leading researchers from academia, government laboratories, and pharmaceutical companies offers essential insight into what has been accomplished and where the experimental therapy of cancer is going. The …
Antifolate Drugs in Cancer Therapy
Inbunden, 1999
2247 kr
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Antifolates are an important class of anticancer drugs originally developed as anti leu- kemic agents, but now used, usually in combination with other drugs, for the treatment of a wide range of tumors, notably carcinomas of the head and neck, breast, germ cell tumors, non-Hodgkin's lymphoma, acute …
Platinum-Based Drugs in Cancer Therapy
Av Lloyd R. Kelland, Nicholas P. Farrell
Inbunden, 2000
1687 kr
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Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, …
Farnesyltransferase Inhibitors in Cancer Therapy
Av Saïd M. Sebti, Andrew D. Hamilton
Inbunden, 2000
1687 kr
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Cutting-edge researchers describe their efforts to design, synthesize, and evaluate the biological activities of farensyltransferase inhibitors (FTIs); geranylgeranyltransferase inhibitors (GGTIs) are also discussed as potential anticancer drugs. The authors survey in detail such inhibitors as CAAX …
Matrix Metalloproteinase Inhibitors in Cancer Therapy
Av Neil J. Clendeninn, Krzysztof Appelt
Inbunden, 2000
1687 kr
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Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for …
Hormone Therapy in Breast and Prostate Cancer
Av JORDAN V. CRAIG, B.J.A. Furr
Inbunden, 2002
1687 kr
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In Hormone Therapy in Breast and Prostate Cancer, many of today's leading researchers and clinicians describe the principles underlying targeted hormonal treatments, assess the actions of new and established agents, and illustrate the new applications of hormonal chemoprevention for breast cancer. …
Signaling Networks and Cell Cycle Control
The Molecular Basis of Cancer and Other Diseases
Inbunden, 2000
1687 kr
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Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their …
Apoptosis and Cancer Chemotherapy
Av John A. Hickman, Caroline Dive
Inbunden, 1999
1687 kr
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This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agents to the mechanisms coupling DNA damage to the activation pathway of apoptosis. It …
Tumor Suppressor Genes in Human Cancer
Inbunden, 2000
2247 kr
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David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the …
Cytokines in the Genesis and Treatment of Cancer
Av Michael A. Caligiuri, Michael T. Lotze
Inbunden, 2007
2247 kr
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Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into …
Drug Delivery Systems in Cancer Therapy
Inbunden, 2003
2247 kr
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Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify …
Tumor Targeting in Cancer Therapy
Av Michel Pagé
Inbunden, 2002
2247 kr
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In Tumor Targeting in Cancer Therapy, Dr. Michel Page and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many …
Cell Cycle Inhibitors in Cancer Therapy
Current Strategies
Av Shawn J. Perich, Antonio Giordano m. fl.
Inbunden, 2002
1687 kr
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Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle …
Targets for Cancer Chemotherapy
Transcription Factors and Other Nuclear Proteins
Av Nicholas B. La Thangue, Lasantha R. Bandara
Inbunden, 2002
1687 kr
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In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their …
Fluoropyrimidines in Cancer Therapy
Av Randy M. Leffingwell, Youcef M. Rustum m. fl.
Inbunden, 2002
1687 kr
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Leading cancer researchers update and review the mechanisms of action and the therapeutic selectivity and efficacy of 5-FU with and without leucovorin and its prodrugs in the treatment of colorectal cancer. Among the combination agents considered are UFT/LV, 5-FU/EU, capecitabine (Xeloda), S-1, and …
Oncogene-Directed Therapies
Av Marcus Schneck, Janusz Rak m. fl.
Inbunden, 2002
1687 kr
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Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors …
Macromolecular Anticancer Therapeutics
Av L. Harivardhan Reddy, Patrick Couvreur
Inbunden, 2009
3153 kr
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In spite of the development of various anticancer drugs, the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic concentrations, intrinsic or acquired …
Nitric Oxide (NO) and Cancer
Prognosis, Prevention, and Therapy
Inbunden, 2010
2254 kr
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Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the …
Tumor Microenvironment
Inbunden, 2010
2254 kr
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The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor …
Principles of Anticancer Drug Development
Inbunden, 2010
1693 kr
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A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.
DNA Topoisomerases and Cancer
Av Yves Pommier
Inbunden, 2011
2249 kr
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DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include …
Insulin-like Growth Factors and Cancer
From Basic Biology to Therapeutics
Inbunden, 2011
1689 kr
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The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.
Natural Killer T cells
Balancing the Regulation of Tumor Immunity
Av Masaki Terabe, Jay A. Berzofsky
Inbunden, 2011
1128 kr
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This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells.
Macromolecular Anticancer Therapeutics
Av L. Harivardhan Reddy, Patrick Couvreur
Häftad, 2012
2940 kr
Lägg i varukorg
In spite of the development of various anticancer drugs, the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic concentrations, intrinsic or acquired …
Nitric Oxide (NO) and Cancer
Prognosis, Prevention, and Therapy
Häftad, 2012
2249 kr
Lägg i varukorg
Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the …
Tumor Microenvironment
Häftad, 2012
2249 kr
Lägg i varukorg
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor …
Principles of Anticancer Drug Development
Häftad, 2013
1689 kr
Lägg i varukorg
A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.
Natural Killer T cells
Balancing the Regulation of Tumor Immunity
Av Masaki Terabe, Jay A. Berzofsky
Häftad, 2013
1128 kr
Lägg i varukorg
This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells.
Insulin-like Growth Factors and Cancer
From Basic Biology to Therapeutics
Häftad, 2013
1689 kr
Lägg i varukorg
The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.
DNA Topoisomerases and Cancer
Av Yves Pommier
Häftad, 2013
2249 kr
Lägg i varukorg
DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include …
