Oncogene-Directed Therapies

"The book is well referenced, and readers will easily be able to locate primary literature for in-depth reading on specific topics. The figures and illustrations are extremely useful in summarizing complex topics that are discussed. In summary, this is an unique, well-organized, and timely presentation on a topic of high importance. People who will find this volume especially useful include students of tumor biology, basic scientists with an interest in novel therapeutic or translational research, and all clinicians who are involved in the diagnosis and treatment of patients with cancer." - Neuro-oncology "This book attempts to cover a vast and rapidly evolving field of research, both basic and clinical, and does so successfully by giving the reader a balanced mix of basic science, experimental therapeutics and clinical observations. Most chapters are richly illustrated and all have extensive lists of relevant references." - Medical Oncology "...this book will be useful not only to those just starting their research careers, including graduate and medical students, but also to those who have been involved in the field of cancer biology and treatment for a number of years, including seasoned scientists and clinicians." -Doody's Health Sciences Book Review Journal

• I. Basic Concepts in Oncogene Research.- 1 Genetic Basis of Cancer Progression.- 2 The Molecular Basis of Chromosomal Instability in Human Cancer Cells.- 3 Signal Transduction Networks: Ras as a Paradigm.- 4 Oncogenic Receptor Tyrosine Kinases.- 5 Ras-Mediated Deregulation of Gene Expression and Contribution to Oncogenesis.- 6 The Interplay Between Tumor Suppressor Genes and Oncogenes in Tumorigenesis.- 7 Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment.- II. The Functional Impact of Oncogene Expression on Cancer Cellstherapeutic Implications.- 8 Deregulation of Cell Cycle Progression by Oncogenic Transformation.- 9 Oncogenes as Regulators of Cell Survival: The Role of Oncogenes and Tumor Suppressor Genes in the Induction of Resistance to Anoikis and Hypoxia.- 10 Oncogenes and Tumor Angiogenesis.- 11 Oncogenes as Therapeutic Targets to Prevent Metastasis.- 12 The Impact of Oncogenes on Tumor Maintenance.- 13 Primary and Secondary Events in Oncogene-Driven Tumor Development: Lessons from Transgenic Model Systems.- III. Oncogenes as Targets for Anticancer Therapy In Vivo.- 14 Targeting Oncogenes in Hematopoietic Malignancies.- 15 Clinical Evaluation of Agents Targeting Epidermal Growth Factor Receptor (EGFR) in Cancer.- 16 Inhibition of the HER-2/neu Oncogene: A Translational Research Model for the Development of Future Targeted Therapies.- 17 Farnesyltransferase Inhibitors as Anticancer Agents.- 18 Targeting Oncogenic Signaling Pathways in Human Astrocytomas.- 19 Targeting Oncogenes in Pediatric Malignancies.- 20 Inhibiting Signal Transduction as an Approach to Radiosensitizing Tumor Cells.- 21 Oncogenes as Targets for Cancer Vaccines.- 22 Bcl-2 Antisense Oligonucleotides Therapy for Cancer: Targeting the Mitochondria.