Born and raised in the Netherlands, Dr Jan Pol is star of the National Geographic television show The Incredible Dr. Pol. He has been treating animals in Michigan since the 1970s. His more than 20,000 patients have ranged from white mice to horses and everything in between. In Never Turn Your Back On An Angus Cow, Dr Pol shares his own story of growing up surrounded by animals, training to be a vet in the Netherlands and moving to Michigan to open his first practice.

In this issue of Hematology/Oncology Clinics, guest editor Dr. David E. Fisher brings his considerable expertise to the topic of Cutaneous Oncology. Top experts first provide information on skin structure, function, and immunology, then offer overviews of the therapeutic state of the art for both melanoma and non-melanoma skin cancers. Discussions focus on unique clinical challenges and biological breakthroughs which have come to light in recent studies of cutaneous malignancies.

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

The field of melanoma biology has experienced a remarkable surge in recent years, owing to progress which has ranged from the most basic laboratory/preclinical discoveries to clinical developments that have begun to transform the management and prognosis for at least certain melanoma patients. Among the key areas that have contributed to this progress are studies relating to signaling and transcriptional pathways that regulate control over differentiation and survival of the melanocyte lineage. The identification of recurring activating mutations in specific signaling factors (B-RAF, N-Ras, c-KIT), amplification of other melanoma oncogenes (MITF, NEDD9), and the crucial recognition that certain of these genomic events occur within melanomas arising with specific clinical features (eg mucosal or acral origin) have led to clear recognition that melanoma is indeed "many different diseases.� While the various subclasses of melanoma may share common features, such as profound invasive and metastatic propensity, it is also likely that sharply focused therapeutic strategies may exploit the functionally critical molecular engines, which distinguish these subclasses. Certain strategies focus upon the immunogenicity and striking clinical opportunities afforded by immune modulation, while others focus more directly on tumor-specific targeting. This issue brings together some of the leaders who have contributed significant insights from basic melanoma biology to progress in the clinic.

Melanoma is a cutting edge, comprehensive reference work on the topic of melanoma. The overarching goal is to provide detailed scholarly information which broadly covers all aspects of the clinical presentation and management of the disease, as well as the biological and scientific understanding of its pathogenesis and treatment. Key topics highlighted include recent breakthroughs in molecular diagnostics, breakthroughs in targeted therapeutic approaches, overviews of signaling and transcriptional pathways, and important controversies such as screening, early diagnosis, sentinel node biopsy, and prevention strategies. In all, the volume provides a cutting edge and comprehensive presentation of the field of melanoma, written by a team of internationally renowned thought-leaders.

Melanoma is a cutting edge, comprehensive reference work on the topic of melanoma. The overarching goal is to provide detailed scholarly information which broadly covers all aspects of the clinical presentation and management of the disease, as well as the biological and scientific understanding of its pathogenesis and treatment. Key topics highlighted include recent breakthroughs in molecular diagnostics, breakthroughs in targeted therapeutic approaches, overviews of signaling and transcriptional pathways, and important controversies such as screening, early diagnosis, sentinel node biopsy, and prevention strategies. In all, the volume provides a cutting edge and comprehensive presentation of the field of melanoma, written by a team of internationally renowned thought-leaders.

Lord Hugh Dowding, Air Chief Marshall of the Royal Air Force, Head of Fighter Command, First Baron of Bentley Priory, lived in the grip of unseen spirits. In thrall of the supernatural, he talked to the ghosts of his dead pilots, proclaimed that Hitler was defeated only by the personal intervention of God, and believed in the existence of faeries. How could it be that such a man should be put in charge of evaluating technical developments for the British air ministry? Yet it was he who brought the modern multi-gunned fighter into existence. And he insisted that his scientists investigate the mysterious invisible rays that would prove to be the salvation of Britain: radar. Dowding, who provided the organization and training that led to victory, has been all but ignored by U. S. biographers of Churchill and historians of the Battle of Britain. Yet his story is vital to tell, for its importance to the defense of Britain and the free world, and for the intriguing character study that emerges from his ongoing conflict with Churchill and the British government during the crisis years of the empire. Part military history, part science narrative, part biography; this an incredible story.

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Born and raised in the Netherlands, Dr Jan Pol is star of the National Geographic television show The Incredible Dr. Pol. He has been treating animals in Michigan since the 1970s. His more than 20,000 patients have ranged from white mice to horses and everything in between. In Never Turn Your Back On An Angus Cow, Dr Pol shares his own story of growing up surrounded by animals, training to be a vet in the Netherlands and moving to Michigan to open his first practice.

In this issue of Hematology/Oncology Clinics, guest editor Dr. David E. Fisher brings his considerable expertise to the topic of Cutaneous Oncology. Top experts first provide information on skin structure, function, and immunology, then offer overviews of the therapeutic state of the art for both melanoma and non-melanoma skin cancers. Discussions focus on unique clinical challenges and biological breakthroughs which have come to light in recent studies of cutaneous malignancies.

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

The field of melanoma biology has experienced a remarkable surge in recent years, owing to progress which has ranged from the most basic laboratory/preclinical discoveries to clinical developments that have begun to transform the management and prognosis for at least certain melanoma patients. Among the key areas that have contributed to this progress are studies relating to signaling and transcriptional pathways that regulate control over differentiation and survival of the melanocyte lineage. The identification of recurring activating mutations in specific signaling factors (B-RAF, N-Ras, c-KIT), amplification of other melanoma oncogenes (MITF, NEDD9), and the crucial recognition that certain of these genomic events occur within melanomas arising with specific clinical features (eg mucosal or acral origin) have led to clear recognition that melanoma is indeed "many different diseases.� While the various subclasses of melanoma may share common features, such as profound invasive and metastatic propensity, it is also likely that sharply focused therapeutic strategies may exploit the functionally critical molecular engines, which distinguish these subclasses. Certain strategies focus upon the immunogenicity and striking clinical opportunities afforded by immune modulation, while others focus more directly on tumor-specific targeting. This issue brings together some of the leaders who have contributed significant insights from basic melanoma biology to progress in the clinic.

Melanoma is a cutting edge, comprehensive reference work on the topic of melanoma. The overarching goal is to provide detailed scholarly information which broadly covers all aspects of the clinical presentation and management of the disease, as well as the biological and scientific understanding of its pathogenesis and treatment. Key topics highlighted include recent breakthroughs in molecular diagnostics, breakthroughs in targeted therapeutic approaches, overviews of signaling and transcriptional pathways, and important controversies such as screening, early diagnosis, sentinel node biopsy, and prevention strategies. In all, the volume provides a cutting edge and comprehensive presentation of the field of melanoma, written by a team of internationally renowned thought-leaders.

Melanoma is a cutting edge, comprehensive reference work on the topic of melanoma. The overarching goal is to provide detailed scholarly information which broadly covers all aspects of the clinical presentation and management of the disease, as well as the biological and scientific understanding of its pathogenesis and treatment. Key topics highlighted include recent breakthroughs in molecular diagnostics, breakthroughs in targeted therapeutic approaches, overviews of signaling and transcriptional pathways, and important controversies such as screening, early diagnosis, sentinel node biopsy, and prevention strategies. In all, the volume provides a cutting edge and comprehensive presentation of the field of melanoma, written by a team of internationally renowned thought-leaders.

Lord Hugh Dowding, Air Chief Marshall of the Royal Air Force, Head of Fighter Command, First Baron of Bentley Priory, lived in the grip of unseen spirits. In thrall of the supernatural, he talked to the ghosts of his dead pilots, proclaimed that Hitler was defeated only by the personal intervention of God, and believed in the existence of faeries. How could it be that such a man should be put in charge of evaluating technical developments for the British air ministry? Yet it was he who brought the modern multi-gunned fighter into existence. And he insisted that his scientists investigate the mysterious invisible rays that would prove to be the salvation of Britain: radar. Dowding, who provided the organization and training that led to victory, has been all but ignored by U. S. biographers of Churchill and historians of the Battle of Britain. Yet his story is vital to tell, for its importance to the defense of Britain and the free world, and for the intriguing character study that emerges from his ongoing conflict with Churchill and the British government during the crisis years of the empire. Part military history, part science narrative, part biography; this an incredible story.

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.