"...extremely readable...excellent treatment of drugs such as naphthalimides...Each chapter is succinct and well-written." -Cancer Forum "...a most important source of literature for all those who are involved in basic cancer research and in the clinical care of cancer patients in different fields of medicine." -Haematologia

• I. Cytotoxic Agents: Old and New.- 1 Nitrogen Mustards.- 2 Phosphoramide and Oxazaphosphorine Mustards.- 3 Development of the Nitrosoureas.- 4 Platinum Complexes.- 5 Anthracyclines.- 6 Topoisomerase I Inhibitors.- 7 DNA Topoisomerase II Inhibitors.- 8 The Taxoids.- 9 Sequence-Selective Groove Binders.- 10 Bis-Naphthalimides: Synthesis and Preclinical Evaluation.- II. Newer Strategies and Targets.- 11 The Enediynes.- 12 Matrix Metalloproteinase Inhibitors.- 13 Interferons and Other Cytokines.- 14 Discovery of TNP-470 and Other Angiogenesis Inhibitors.- 15 Antisense Oligonucleotides.- 16 Growth Factors and Growth Factor Inhibitors.- 17 Immunoconjugates.- 18 A Case for ras Targeted Agents as Antineoplastics.- 19 Gene Therapy.

"...extremely readable...excellent treatment of drugs such as naphthalimides...Each chapter is succinct and well-written." -Cancer Forum "...a most important source of literature for all those who are involved in basic cancer research and in the clinical care of cancer patients in different fields of medicine." -Haematologia

• I. Cytotoxic Agents: Old and New.- 1 Nitrogen Mustards.- 2 Phosphoramide and Oxazaphosphorine Mustards.- 3 Development of the Nitrosoureas.- 4 Platinum Complexes.- 5 Anthracyclines.- 6 Topoisomerase I Inhibitors.- 7 DNA Topoisomerase II Inhibitors.- 8 The Taxoids.- 9 Sequence-Selective Groove Binders.- 10 Bis-Naphthalimides: Synthesis and Preclinical Evaluation.- II. Newer Strategies and Targets.- 11 The Enediynes.- 12 Matrix Metalloproteinase Inhibitors.- 13 Interferons and Other Cytokines.- 14 Discovery of TNP-470 and Other Angiogenesis Inhibitors.- 15 Antisense Oligonucleotides.- 16 Growth Factors and Growth Factor Inhibitors.- 17 Immunoconjugates.- 18 A Case for ras Targeted Agents as Antineoplastics.- 19 Gene Therapy.

"...extremely readable...excellent treatment of drugs such as naphthalimides...Each chapter is succinct and well-written." -Cancer Forum "...a most important source of literature for all those who are involved in basic cancer research and in the clinical care of cancer patients in different fields of medicine." -Haematologia

• I. Cytotoxic Agents: Old and New.- 1 Nitrogen Mustards.- 2 Phosphoramide and Oxazaphosphorine Mustards.- 3 Development of the Nitrosoureas.- 4 Platinum Complexes.- 5 Anthracyclines.- 6 Topoisomerase I Inhibitors.- 7 DNA Topoisomerase II Inhibitors.- 8 The Taxoids.- 9 Sequence-Selective Groove Binders.- 10 Bis-Naphthalimides: Synthesis and Preclinical Evaluation.- II. Newer Strategies and Targets.- 11 The Enediynes.- 12 Matrix Metalloproteinase Inhibitors.- 13 Interferons and Other Cytokines.- 14 Discovery of TNP-470 and Other Angiogenesis Inhibitors.- 15 Antisense Oligonucleotides.- 16 Growth Factors and Growth Factor Inhibitors.- 17 Immunoconjugates.- 18 A Case for ras Targeted Agents as Antineoplastics.- 19 Gene Therapy.