Dermal Absorption and Toxicity Assessment

AvMichael S. Roberts

E-bok

Engelska, 2007

Del i serien Drugs and the Pharmaceutical Sciences

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Beskrivning

The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab

Produktinformation

Utgivningsdatum:2007-12-14
Språk:Engelska
Filformat:EPUB
Kopieringsskydd:LCP
ISBN:9781040169629
Förlag:Taylor & Francis Ltd
Upplaga:2
Serie:Drugs and the Pharmaceutical Sciences

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Innehållsförteckning

INTRODUCTION. Human Skin Morphology and Dermal Absorption. Animal Skin Morphology and Dermal Absorption. SKIN BARRIER PROPERTIES AND ABSORPTION. The Physical Structure of the Skin Barrier. Skin Lipid Morphology and Function. Stratum Corneum as a Biosensor ;. Cutaneous Metabolism. Formulation Issues. MEASUREMENT OF SKIN ABSORPTION. Interpretation of In Vitro Skin Absorption Studies of Lipophilic Chemicals. Use of Skin Equivalents for Dermal Absorption and Toxicity. Skin Absorption as Studied by Spectroscopic Methods. MODELING OF DERMAL ABSORPTION AND RISK ASSESSMENT. Physiologically Based Pharmacokinetics and Pharmacodynamics of Skin. Beyond Stratum Corneum. Biophysical Models for Skin Transport and Absorption. Mathematical Models for Different Exposure Conditions.Modelling Skin Permeability in Risk Assessment. In Vitro-In Vivo Correlations in Transdermal Drug Delivery. Estimation of Subsequent Systemic Exposure - Physiological Models. "Riskofderm" - Predictions Based on In Vivo Factors. SKIN TOXICITY AND PREVENTION Quantitative Structure Activity Relationships for Skin Corrosivity and Toxicity Allergic Contact Dermatitis. Irritancy of Topical Chemicals and Transdermal Delivery Systems. Phototoxicity, Photocarcinogenicity and Photogenicity Systemic Toxicity in Man Secondary to Percutaneous Absorption. Effects of Solvents and Other Vehicles on the Stratum Corneum and Other Skin Components. REGULATORY ISSUES. Dermal Absorption of Chemicals: Some Australian Regulatory Considerations. International Perspectives in Dermal Absorption.Structure-Activity Relationships and Prediction of Photoallergic and Phototoxic Potential. Potential Regulatory Use of (Q)SARs to Develop Dermal Irritation and Corrosion Assessment Strategies. Development of (Q)SARs for Dermal Irritation and Corrosion Assessment Using EU New Chemicals Notification Data. Regulatory Assessment of Skin Sensitization. Assessment of Topical Bioequivalence Using Microdialysis and Other Techniques An Industry Pe