Immuno-Oncology

Cellular and Translational Approaches

AvSeng-Lai Tan

Häftad, Engelska, 2021

Del i serien Methods in Pharmacology and Toxicology

1 327 kr

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Beskrivning

This book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action.

Produktinformation

Utgivningsdatum:2021-03-24
Mått:178 x 254 x 16 mm
Vikt:525 g
Format:Häftad
Språk:Engelska
Serie:Methods in Pharmacology and Toxicology
Antal sidor:262
Förlag:Springer-Verlag New York Inc.
ISBN:9781071601730

Utforska kategorier

Onkologi inom Medicin
Kemi inom Naturvetenskap och teknik

Innehållsförteckning

An In Vitro System Combining Tumor Cells and Lymphocytes to Predict the In Vivo Response of Immunomodulatory Antibodies.- High-Throughput Direct Cell Counting Method for Immuno-Oncology Functional Assays Using Image Cytometry.- In Vitro Immunotherapy Potency Assays Using Real-Time Cell Analysis.- Assessing the Potency of T Cell-Redirecting Therapeutics Using In Vitro Cancer Cell Killing Assays.- Induction and Potential Reversal of a T Cell Exhaustion-Like State: In Vitro Potency Assay for Functional Screening of Immune Checkpoint Drug Candidates.- Validation of an Image-Based 3D Natural Killer Cell-Mediated Cytotoxicity Assay.- 3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment.- Considerations in Developing Reporter Gene Bioassays for Biologics.- Miniaturized Single Cell Imaging for Developing Immuno-Oncology Combinational Therapies.- Precision Medicine: The Function of Receptor Occupancy in Drug Development.- In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics.- The Quest for the Next-Generation of Tumor Targets: Discovery and Prioritization in the Genomics Era.